Dental & Oral Health
How your genes affect dental caries susceptibility, periodontal disease risk, enamel quality, and oral cancer risk
This category covers salivary buffering capacity and caries susceptibility (CA6/gustin), enamel mineralization quality (AMELX amelogenin), aggressive periodontitis risk through innate immune defensin pathways (DEFA1A3 alpha-defensins, GLT6D1 glycosyltransferase), and oral tissue carcinogen metabolism (CYP1A1). These variants influence how effectively your saliva neutralizes plaque acids, how well your enamel resists demineralization, how your gingival immune system responds to periodontal pathogens, and how oral tissues process environmental carcinogens.
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Genetic Variants (5)
rs2274327
(CA6 Thr55Met)Reduces salivary carbonic anhydrase VI (gustin) secretion, impairing oral acid buffering and increasing susceptibility to dental caries
rs17878486
(AMELX)Intronic variant in amelogenin X-linked gene affecting enamel mineralization and susceptibility to dental caries and developmental enamel defects
rs1537415
(GLT6D1)Intronic variant in GLT6D1 reducing GATA-3 transcription factor binding in T cells, increasing aggressive periodontitis risk
rs2738058
(DEFA1A3)Intergenic variant downstream of the DEFA1A3 alpha-defensin locus; T risk allele is associated with a 28% increased risk of periodontitis through altered neutrophil defensin availability in the gingival immune response
rs4646903
(CYP1A1 *2A (MspI, T3801C))Regulatory variant in the 3'-flanking region of CYP1A1 that increases gene inducibility, producing more carcinogen-activating enzyme in oral and airway tissues upon tobacco smoke or dietary PAH exposure