Warfarin sensitivity - determines initial dosing

Intronic variant in the complement receptor 1 gene; the minor A allele increases late-onset Alzheimer's disease risk with an odds ratio of ~1.21

Common variant in the Nav1.7 sodium channel affecting pain sensitivity and pain threshold

Intronic variant affecting thermal pain sensitivity and central pain signal transmission

Intergenic variant at the HTR1F locus on chromosome 3; the minor A allele increases migraine susceptibility at genome-wide significance and sits within the genomic region encoding the 5-HT1F serotonin receptor — the direct drug target of lasmiditan (Reyvow), the first ditan-class migraine treatment

Splicing variant in the IL-7 receptor alpha chain that shifts the balance toward soluble receptor, amplifying IL-7 signaling and raising susceptibility to multiple sclerosis and related autoimmune conditions

Intronic variant in GAB2 that modulates late-onset Alzheimer's disease risk; the minor G allele is protective

Connexin 26 missense variant causing partial loss of cochlear gap junction function; the leading cause of mild-to-moderate hereditary hearing loss in East Asian populations

Second strongest genetic risk factor for Alzheimer's disease after APOE, associated with increased tau pathology and accelerated cognitive decline

Rare missense variant in microglial receptor TREM2 that significantly increases late-onset Alzheimer's disease risk through impaired microglial function and amyloid clearance