Research — GeneOps

rs692383 — ABCG1 ABCG1 HDL-c Variant

Chromosome 21 Risk Allele A Category Triglycerides & Fatty Acids HDL Cholesterol, Triglycerides, Cholesterol, Cardiovascular, Fat Metabolism, Obesity

Intronic variant in the ABCG1 cholesterol efflux transporter gene associated with differential HDL-cholesterol response during calorie-restricted dieting; G allele carriers preserve HDL-c more effectively, while AA homozygotes show greater HDL-c reduction when losing weight.

rs767870 — ADIPOR2 ADIPOR2 intron 6 variant

Chromosome 12 Risk Allele G Category Fat Storage & Energy Insulin Resistance, Diabetes, Fat Metabolism, Liver Health, Metabolic, Cardiovascular

Intronic variant in ADIPOR2 (adiponectin receptor 2) associated with reduced insulin sensitivity and increased type 2 diabetes risk; the G allele impairs adiponectin-driven PPARα and AMPK signaling that governs fatty acid oxidation and hepatic glucose metabolism

rs2303065 — SPINK5 SPINK5 His396His (c.1188T>C)

Chromosome 5 Risk Allele T Category Allergy & Atopic Disease Skin Health, Autoimmune, Inflammation, Protease Inhibitor, Asthma, Skin & Eyes

Synonymous variant in SPINK5 exon 13 that tags the same risk haplotype as the nearby functional Lys420Glu variant (rs2303067), associated with atopic dermatitis susceptibility through linkage disequilibrium rather than a direct protein-altering effect

rs356219 — SNCA

Chromosome 4 Risk Allele G Category Neurology & Cognition Neurological Risk, Parkinson's, Neuroprotection, Brain Health, Oxidative Stress, Cognitive Decline

SNCA 3′-region regulatory variant that upregulates alpha-synuclein expression and independently increases Parkinson's disease risk, earlier onset, and cognitive decline

rs3788200 — SLC19A1 SLC19A1 intron 2 variant

Chromosome 21 Risk Allele G Category Methylation & Detox Methylation, Folate, B Vitamins, Homocysteine

Intronic SLC19A1 tag variant in strong LD with the G80A folate-transporter coding variant — marks reduced folate carrier efficiency

rs3814637 — CYP2C19

Chromosome 10 Risk Allele T Category Pharmacogenomics Drug Metabolism, Warfarin, Pharmacogenomics, Cardiovascular, Drug Response

Upstream CYP2C19 variant associated with altered R-warfarin clearance and increased exposure to CYP2C19 substrates

rs5030868 — G6PD G6PD Mediterranean

Chromosome X Risk Allele A Category Blood Sugar & Diabetes Erythropoiesis, Oxidative Stress, Drug Metabolism, Pharmacogenomics, Diabetes, Ancestry-Specific, Drug Safety

Severe Class II G6PD deficiency variant (c.563C>T, p.Ser188Phe) causing less than 10% residual enzyme activity and high risk of acute hemolytic anemia from drugs, fava beans, and infections; prevalent across Mediterranean, Middle Eastern, and South Asian populations

rs5443 — GNB3 C825T

Chromosome 12 Risk Allele T Category Hormones & Sleep Hypertension, Blood Pressure, Antidepressants, Cardiovascular, Obesity, Metabolic Syndrome, Hormones, Neurotransmitters

Synonymous exon-10 variant that triggers alternative splicing of the G-protein beta-3 subunit, amplifying signaling through virtually every GPCR — affecting blood pressure, weight regulation, hormonal responses, sleep timing, and antidepressant efficacy

rs8034802 — LIPC

Chromosome 15 Risk Allele A Category Triglycerides & Fatty Acids Fat Metabolism, HDL Cholesterol, Cholesterol, Cardiovascular, Lifestyle

Intronic LIPC variant associated with higher baseline HDL-C and an amplified HDL-C response to intensive lifestyle intervention — particularly relevant for people with obesity and type 2 diabetes

rs822391 — ADIPOQ IVS1+407C>T

Chromosome 3 Risk Allele C Category Fat Storage & Energy Adipogenesis, Insulin Resistance, Cardiovascular, Metabolic Health, Omega-3, Blood Pressure

Intronic variant in the adiponectin gene associated with circulating adiponectin levels, ischemic stroke risk, and metabolic cardiovascular traits; the C allele — present in roughly 14% of people globally and 20% of Europeans — is linked to lower adiponectin output and elevated cerebrovascular risk