Intergenic GWAS locus near EIF4EBP1 (encoding the mTOR translation repressor 4E-BP1) where the T allele is associated with modestly lower circulating anti-Müllerian hormone (AMH), a key biomarker of ovarian reserve and fertility timing

Common 3'UTR variant in VAMP8 associated with modestly elevated myocardial infarction and noncardioembolic stroke risk

Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit synaptic function to appetite dysregulation and addictive eating patterns

Intronic variant in CHD7, a chromatin remodeler critical for neural crest cell and skeletal development; the G allele is associated with susceptibility to adolescent idiopathic scoliosis

Intronic variant in TLK1 (tousled like kinase 1), a DNA-damage-repair and chromatin-assembly kinase; each copy of the T allele may be associated with earlier age at natural menopause by approximately 10 weeks, suggesting a modest influence on ovarian reserve and reproductive lifespan

Missense variant in IL1RL1 encoding the Leu551Ser amino acid change in the intracellular TIR signaling domain; the T (Leu551) allele tags a four-amino-acid risk haplotype that amplifies IL-33/ST2 receptor signaling, increasing susceptibility to asthma and chronic rhinosinusitis

Promoter variant that increases CCL2 (MCP-1) transcription, amplifying monocyte recruitment to arterial walls and elevating atherosclerotic plaque risk

GLP-1 receptor signal peptide variant that enhances semaglutide and tirzepatide weight loss efficacy but increases nausea and vomiting risk

Deep intronic FBN1 variant associated with larger ascending aortic dimensions and elevated risk of thoracic aortic aneurysm and dissection through altered fibrillin-1 microfibril function and dysregulated TGF-β sequestration in the aortic wall

Common tyrosinase variant affecting melanin production, skin pigmentation, tanning ability, freckling, and melanoma risk