Research — GeneOps

rs12551256 — IL33 IL33 protective asthma variant

Chromosome 9 Risk Allele A Category Allergy & Atopic Disease Asthma, Innate Immunity, Inflammation, Lung Health, Immune Response, Respiratory Infections

Intronic IL33 variant where the G allele is negatively associated with asthma (OR 0.71) in a Brazilian mixed-ancestry cohort; the G allele may dampen IL-33 alarmin output from damaged airway epithelium, reducing ILC2 and mast cell activation and blunting type 2 airway inflammation

rs12598836 — HMOX2

Chromosome 16 Risk Allele G Category Neurology & Cognition Migraine, Brain Health, Nitric Oxide, Oxidative Stress, Cardiovascular, Pain Sensitivity, Cerebrovascular

Intronic variant near heme oxygenase 2 (HMOX2) associated with migraine-with-aura susceptibility; the G allele (GRCh38 reference) tags a regulatory effect on constitutive CO production in cerebral vessels, modulating cerebrovascular reactivity relevant to aura pathophysiology

rs13412852 — LPIN1

Chromosome 2 Risk Allele T Category Fat Storage & Energy Fat Metabolism, Liver Health, Energy Metabolism, Metabolic, Lifestyle, Inflammation

Intronic variant in LPIN1 (lipin-1) associated with liver fat accumulation and MASLD risk; the T allele interacts with sedentary behavior to substantially amplify adult fatty liver risk, while being protective against fibrosis in children

rs16947 — CYP2D6 *2

Chromosome 22 Risk Allele A Category Pharmacogenomics Pharmacogenomics, Drug Metabolism, Antidepressants, Pain Medication

Common CYP2D6 variant defining the *2 allele; previously considered normal-function but recent evidence shows reduced expression through altered splicing

rs174572 — FADS2

Chromosome 11 Risk Allele T Category Triglycerides & Fatty Acids Omega-3, Fat Metabolism, Micronutrients, Cardiovascular, Diet

Intronic variant in FADS2 that reduces delta-6 desaturase activity, impairing the first rate-limiting step in converting dietary LA to GLA (omega-6) and ALA to stearidonic acid (omega-3), resulting in lower circulating EPA levels in T allele carriers

rs17679445 — PNPO Arg116Gln

Chromosome 17 Risk Allele A Category Hormones & Sleep Sleep, Neurotransmitters, B Vitamins, Melatonin, Serotonin, Hormones

Missense variant in pyridoxamine 5'-phosphate oxidase that reduces the enzyme's efficiency at converting dietary vitamin B6 into active PLP, the essential cofactor for GABA, serotonin, melatonin, and dopamine synthesis; associated with insomnia risk in large GWAS

rs1800206 — PPARA Leu162Val (L162V)

Chromosome 22 Risk Allele G Category Fitness & Body Fat Metabolism, Cardiovascular, Omega-3, Triglycerides, Cholesterol, Diet

Missense variant in PPARA that reduces receptor transcriptional activity, elevating LDL and triglycerides — particularly with low dietary PUFA intake — and blunting the lipid-improving response to omega-3 fatty acids and aerobic exercise

rs1800775 — CETP -629C>A

Chromosome 16 Risk Allele C Category Cholesterol & Lipoproteins HDL Cholesterol, Cholesterol, Fat Metabolism, Cardiovascular, Lipid Metabolism

CETP promoter variant that reduces CETP expression via Sp1/Sp3 repression, raising HDL cholesterol by ~3–6 mg/dL in A allele carriers

rs1800872 — IL10 -592 C>A

Chromosome 1 Risk Allele T Category Vascular Inflammation & Remodeling Inflammation, Cardiovascular, Immune & Autoimmune, Diabetes, Metabolic Syndrome, Stress, Diet, Lifestyle

Promoter variant affecting IL-10 production — a key anti-inflammatory cytokine regulating inflammation and cardiovascular risk

rs1937 — TFAM S12T

Chromosome 10 Risk Allele G Category Longevity & Aging Mitochondria, Longevity, Aging, Oxidative Stress, Alzheimer's, Neurodegeneration

Missense variant in the TFAM mitochondrial targeting sequence — the C allele (Thr12) is associated with longevity and reduced Alzheimer's disease risk via preserved mitochondrial DNA maintenance