Heart & Inflammation

How your genes influence cardiovascular risk, inflammatory signaling, and vascular aging

This category covers genetic variants affecting coronary artery disease risk (9p21 locus, LPA, PCSK9), lipid metabolism (CETP, APOB, PON1), vascular function (NOS3, AGTR1), inflammatory cytokine production (CRP, IL-1beta, TNF, IL-6, IL-10), and longevity-associated stress resistance (FOXO3, klotho). These pathways interact to shape cardiovascular health, inflammatory load, and recovery capacity.

Genetic Variants (17)

rs1333049

(CDKN2B-AS1 9p21)

Strongest genetic risk factor for coronary artery disease and myocardial infarction, common variant affecting atherosclerosis susceptibility independent of traditional risk factors

rs10455872

Intronic variant strongly associated with elevated lipoprotein(a) levels and significantly increased risk of coronary artery disease and aortic valve stenosis

rs11591147

Loss-of-function variant that naturally lowers LDL cholesterol by 15-28% and reduces coronary disease risk by up to 47%

rs708272

Influences HDL cholesterol levels and particle size through effects on cholesterol ester transfer protein activity

rs693

(APOB XbaI (C/T))

Silent variant affecting LDL particle number and lipid metabolism; T allele carriers have higher ApoB, LDL-C, and total cholesterol levels

rs5186

3' UTR variant in angiotensin II type 1 receptor affecting blood pressure regulation and ARB drug response

rs662

Affects paraoxonase-1 enzyme activity for detoxifying organophosphates and protecting LDL from oxidation

rs1205

3' UTR variant that modulates baseline C-reactive protein levels and inflammatory status

rs16944

Promoter variant affecting IL-1 beta production, influencing inflammatory response and cardiovascular disease risk

rs2802292

Longevity-associated intronic enhancer variant with 1.9-fold increased probability of reaching age 95

rs9536314

(KLOTHO F352V (KL-VS))

Longevity-associated variant exhibiting overdominance where heterozygotes show enhanced cognition and lifespan while homozygotes have reduced survival

rs6511720

(LDLR Intron 1)

Common regulatory variant in the LDL receptor gene affecting LDLR expression, baseline LDL cholesterol levels, and statin response

rs12740374

(SORT1 1p13.3 locus)

Regulatory variant that increases sortilin expression, lowering LDL cholesterol and cardiovascular risk

rs5128

(APOC3 3238C>G (SstI))

Regulates triglyceride metabolism through effects on APOC3 expression in the 3'UTR

rs1800947

Synonymous exon 2 variant that influences baseline C-reactive protein expression and inflammatory phenotypes

rs4073

Promoter variant affecting interleukin-8 transcription and inflammatory burden

rs1800872

(IL10 -592 C>A)

Promoter variant affecting IL-10 production — a key anti-inflammatory cytokine regulating inflammation and cardiovascular risk