Regulatory variant 2 kb upstream of SYCP2L; each copy of the minor C allele associates with approximately 0.26 additional years before natural menopause, reflecting altered expression of a meiotic chromosome-pairing protein in oocytes

Intronic regulatory variant in IL1RL1 that lowers soluble ST2 (sST2) decoy receptor levels, amplifying IL-33 signaling and increasing susceptibility to asthma, hay fever, and atopic disease

Intronic GLIS3 variant in which the rare A allele modestly elevates TSH, reflecting reduced thyroid transcriptional activity; the same gene drives pancreatic beta cell development, linking thyroid-axis regulation to metabolic energy balance

Phase II detoxification enzyme that conjugates glutathione to carcinogens, drugs, and oxidative stress products; this variant alters the active site geometry, changing substrate specificity

Influences episodic memory performance and hippocampal function through the KIBRA protein's role in synaptic plasticity

Insulin sensitivity - affects how well your cells respond to insulin

Deep intronic CYP2C9 variant associated with altered drug response to sulfonylurea antidiabetics and other CYP2C9 substrates

Regulatory variant near the HTR6 serotonin 6 receptor gene associated with chronotype; the minor T allele is linked to reduced morningness and a modest shift toward evening preference.

Affects tenascin C protein levels and elasticity, influencing tendon injury risk and exercise-induced tissue adaptation

Intronic FABP1 variant associated with type 2 diabetes risk and insulin resistance; likely tags the functional haplotype containing the T94A missense in the liver fatty acid transport protein