Intronic variant in GPD2 (mitochondrial glycerol-3-phosphate dehydrogenase), second-strongest signal (P=1.5×10⁻²⁹) from the first-ever motion sickness GWAS; the G allele is in high LD with a missense variant

Rare missense variant in CYP3A4 that reduces protein expression and enzymatic activity across multiple drug substrates

Intronic GSDMB variant that acts as an eQTL for ORMDL3; the T allele elevates ORMDL3 expression in airway cells, increasing sphingolipid-pathway ER stress and childhood asthma susceptibility

Missense variant in CACNA1H encoding the CaV3.2 T-type calcium channel; the Leu640 allele alters channel pharmacodynamics, set against a backdrop of CaV3.2's established role in hippocampal memory consolidation and synaptic plasticity.

GLP-1 receptor variant that alters response to GLP-1 agonist medications used for weight loss and type 2 diabetes

Regulatory variant near the EMSY/C11orf30 locus; T allele is the broadest known allergic disease risk allele — associated with atopic dermatitis, asthma, hay fever, and the atopic march

Intronic PRDM16 variant reaching genome-wide significance in the first motion sickness GWAS, with the same risk allele independently associated with migraines — pointing to a shared genetic basis for vestibular vulnerability and migraine susceptibility

Intronic CYP2D6 haplotype tag variant (rs28371702 canonical form) associated with altered drug metabolism ratios for CYP2D6 substrates including aripiprazole and praziquantel

Regulatory variant near C11orf30 (EMSY) on chromosome 11q13.5

Key neurotrophin variant that controls activity-dependent BDNF release, affecting memory consolidation, neuroplasticity, and stress resilience