Missense variant (Pro10Leu) in melanopsin, the photopigment driving circadian photoentrainment; TT carriers show altered light-signaling amplitude and elevated seasonal affective disorder risk

Intronic PPARG variant significantly associated with individual variation in body weight reduction during calorie restriction; G allele also linked to elevated plasma renin activity, suggesting altered PPARγ-mediated adipose-renin axis signalling

Triglyceride metabolism - affects fasting triglyceride levels and cardiovascular risk

Promoter-region variant in SIRT1 affecting deacetylase expression; T allele elevates SIRT1 levels and is associated with better cognition but increased metabolic and cancer risk; C allele is the common protective form

Tag SNP for the ACE insertion/deletion polymorphism — the C allele tracks the insertion (lower ACE activity, endurance advantage) and the G allele tracks the deletion (higher ACE activity, power/strength advantage)

Intronic variant in the myosin heavy chain 15 gene associated with impaired coronary microvascular function and abnormal coronary flow reserve in men (OR 2.27)

Missense variant in the FTCD enzyme that impairs one-carbon unit transfer from histidine catabolism into the folate pool, reducing arsenic methylation efficiency and increasing toxicity risk

Intergenic variant on chromosome 22q11 (merged into rs133255) located downstream of a lncRNA in the immunoglobulin lambda gene cluster region; listed as a 22q11.21 region variant co-identified with TBX1 AIS susceptibility locus rs1978060

Intronic APOB variant associated with modest differences in apolipoprotein B levels, cardiovascular risk, and ischemic stroke susceptibility across populations.

Intronic variant in DAB2IP associated with increased risk of abdominal aortic aneurysm, myocardial infarction, and peripheral arterial disease through impaired Ras-GTPase regulation and enhanced vascular inflammation