Near-gene variant tagging an IRF5 protective haplotype in the 5' promoter region that lowers susceptibility to lupus, rheumatoid arthritis, and related autoimmune conditions

Intronic variant near heme oxygenase 2 (HMOX2) associated with migraine-with-aura susceptibility

Regulatory variant upstream of IL33; the C allele elevates IL-33 expression, amplifying the alarmin signal through the ST2 receptor and raising susceptibility to asthma, allergic rhinitis, hay fever, and eosinophilic airway inflammation

Phase II detoxification enzyme that conjugates glutathione to carcinogens, drugs, and oxidative stress products; this variant alters the active site geometry, changing substrate specificity

Intergenic variant near the lipoprotein lipase gene on 8p21.3; the rare T allele is linked to lower fasting triglycerides and reduced metabolic syndrome risk.

Intronic tag SNP at the 12q24 locus, increasing risk for type 1 diabetes, juvenile idiopathic arthritis, and other autoimmune diseases; also associated with modest effects on lipid levels

Mu-opioid receptor variant affecting opioid response and pain sensitivity

Missense variant in the AGER pattern-recognition receptor that reduces soluble RAGE shedding, amplifying inflammatory signaling via NF-κB and AGE pathway activation; associated with lung disease, diabetic complications, and modulated neuroinflammatory risk

Synonymous IGF1R variant associated with lower circulating IGF-1 levels and enrichment in long-lived populations

Intronic variant in FGFR1OP (CEP43) at the RNASET2-FGFR1OP-CCR6 autoimmune susceptibility locus, with the T allele increasing risk for Crohn's disease