Tag

Biologic Therapy

26 genetic variants with this tag.

RSID	Gene	Description	Category
rs10206753	IL1RL1 IL1RL1 TIR Domain Risk Haplotype	Missense variant in IL1RL1 encoding the Leu551Ser amino acid change in the in...	Allergy & Atopic Disease	Biologic Therapy	Strong
rs11652075	CARD14 CARD14 Arg820Trp (R820W)	Missense variant in the keratinocyte NF-κB scaffold protein CARD14 that modes...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Strong
rs12191877	HLA-C Tag for *06:02	Tag SNP for HLA-C*06:02, the strongest genetic risk factor for psoriasis, det...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Established
rs13190932	TRAF3IP2 R74W	Missense variant in the IL-17 adaptor Act1 (Arg74Trp) that is the primary GWA...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Strong
rs13196377	TRAF3IP2 Intronic haplotype member	Intronic tagging variant in the TRAF3IP2/TRAF3IP2-AS1 locus that distinguishe...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Moderate
rs13210247	TRAF3IP2	Intronic variant in the TRAF3IP2 locus that lies within the antisense lncRNA ...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Strong
rs17881320	STAT3 JAK-STAT3 Signaling Variant	Intronic STAT3 variant associated with increased atopic dermatitis risk (OR=1...	TNF, NF-kB & Inflammatory Cytokines	Biologic Therapy	Strong
rs12133641	IL6R IL-6 receptor intronic variant	Deep intronic IL6R variant associated with atopic dermatitis risk and systemi...	Allergy & Atopic Disease	Biologic Therapy	Strong
rs2546890	LOC285626 LOC285626 rs2546890	Regulatory variant upstream of IL12B associated with increased risk of multip...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Strong
rs2233434	NFKBIE	Missense variant in NFKBIE (IκBε) reducing the inhibitory capacity of the IκB...	TNF, NF-kB & Inflammatory Cytokines	Biologic Therapy	Strong
rs3212227	IL12B 3'UTR	IL12B 3'-UTR variant forming the canonical two-SNP psoriasis risk haplotype w...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Strong
rs3213094	IL12B Promoter-region	Intronic IL12B variant in linkage with the promoter-regulatory haplotype; T a...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Moderate
rs4810485	CD40	Intronic variant in CD40 regulating B-cell surface expression; the G allele d...	B-Cell Immunity & Antibody-Mediated Disease	Biologic Therapy	Strong
rs33980500	TRAF3IP2 D10N	Missense variant in Act1 that abolishes IL-17 signaling by disrupting TRAF6 b...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Strong
rs660895	HLA-DRB1	Regulatory tag SNP in the HLA-DRB1 region; the G allele marks the HLA-DRB1*04...	Interferon Signaling & Systemic Autoimmune	Biologic Therapy	Strong
rs1342326	IL33 IL33 regulatory variant	Regulatory variant upstream of IL33; the C allele elevates IL-33 expression, ...	Allergy & Atopic Disease	Biologic Therapy	Strong
rs1420101	IL1RL1	Intronic regulatory variant in IL1RL1 that lowers soluble ST2 (sST2) decoy re...	Allergy & Atopic Disease	Biologic Therapy	Strong
rs4845625	IL6R	Intronic IL6R variant associated with coronary artery disease risk, elevated ...	TNF, NF-kB & Inflammatory Cytokines	Biologic Therapy	Moderate
rs4537545	IL6R IL6R intron variant	Intronic IL6R variant in linkage disequilibrium with the functional Asp358Ala...	Coronary Artery Disease & Atherosclerosis	Biologic Therapy	Strong
rs61751629	CARD14 Glu422Lys	Rare missense variant in the keratinocyte NF-κB scaffold protein CARD14 that ...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Emerging
rs7152376	NFKBIA	Regulatory variant upstream of NFKBIA that specifically elevates risk of psor...	Psoriasis & Spondyloarthropathy	Biologic Therapy	Moderate
rs1805010	IL4R Ile75Val	Missense variant in the extracellular domain of the IL-4 receptor alpha chain...	Allergy & Atopic Disease	Biologic Therapy	Moderate
rs20541	IL13 R130Q	Missense variant in IL-13 that enhances Th2 cytokine signaling, elevating ser...	Allergy & Atopic Disease	Biologic Therapy	Strong
rs2228145	IL6R Asp358Ala	Missense variant in the IL-6 receptor that increases receptor shedding; the C...	Allergy & Atopic Disease	Biologic Therapy	Strong
rs3939286	IL33 IL33 intronic asthma variant	Regulatory variant ~5 kb upstream of IL33; the T allele is associated with in...	Allergy & Atopic Disease	Biologic Therapy	Strong
rs4129267	IL6R IL6R intronic multi-trait variant	Intronic IL6R variant in perfect linkage disequilibrium with the functional A...	Allergy & Atopic Disease	Biologic Therapy	Strong