Tag

Skin

22 genetic variants with this tag.

RSID	Gene	Description	Category
rs10794648	IFNLR1/GRHL3	Intergenic regulatory variant near IFNLR1 that contacts GRHL3 via chromatin l...	Interferon Signaling & Systemic Autoimmune	Skin	Moderate
rs11652075	CARD14 CARD14 Arg820Trp (R820W)	Missense variant in the keratinocyte NF-κB scaffold protein CARD14 that modes...	Psoriasis & Spondyloarthropathy	Skin	Strong
rs12188300	IL12B	Near-gene variant at the IL12B locus associated with psoriasis risk through a...	Psoriasis & Spondyloarthropathy	Skin	Moderate
rs12191877	HLA-C Tag for *06:02	Tag SNP for HLA-C*06:02, the strongest genetic risk factor for psoriasis, det...	Psoriasis & Spondyloarthropathy	Skin	Established
rs115161931	CTSS	Independent CTSS-locus GWAS signal for atopic dermatitis on chromosome 1q21.3...	Allergy & Atopic Disease	Skin	Moderate
rs17728338	TNIP1 TNIP1/ABIN1 variant	Intergenic regulatory variant near TNIP1 whose A allele reduces ABIN1-mediate...	Psoriasis & Spondyloarthropathy	Skin	Strong
rs2066808	IL23A	Intronic variant near IL23A encoding the IL-23 p19 subunit; G allele increase...	Psoriasis & Spondyloarthropathy	Skin	Strong
rs2256774	IL2RA	Intronic IL2RA variant that modulates soluble IL-2RA shedding and Treg signal...	Autoimmune Tolerance & T-Cell Regulation	Skin	Moderate
rs12123821	FLG Filaggrin skin barrier variant	Common regulatory variant in the FLG locus associated with impaired skin barr...	Allergy & Atopic Disease	Skin	Strong
rs3212227	IL12B 3'UTR	IL12B 3'-UTR variant forming the canonical two-SNP psoriasis risk haplotype w...	Psoriasis & Spondyloarthropathy	Skin	Strong
rs3213094	IL12B Promoter-region	Intronic IL12B variant in linkage with the promoter-regulatory haplotype; T a...	Psoriasis & Spondyloarthropathy	Skin	Moderate
rs3805435	TNIP1	Intronic variant in the GPX3/TNIP1 regulatory locus on chromosome 5; the C al...	Psoriasis & Spondyloarthropathy	Skin	Moderate
rs610604	TNFAIP3	Intronic variant in TNFAIP3 whose G allele is the primary psoriasis susceptib...	Psoriasis & Spondyloarthropathy	Skin	Strong
rs1420101	IL1RL1	Intronic regulatory variant in IL1RL1 that lowers soluble ST2 (sST2) decoy re...	Allergy & Atopic Disease	Skin	Strong
rs61751629	CARD14 Glu422Lys	Rare missense variant in the keratinocyte NF-κB scaffold protein CARD14 that ...	Psoriasis & Spondyloarthropathy	Skin	Emerging
rs146527530	CTSS CTSS AD Risk Signal (Budu-Aggrey 2023)	Third independent CTSS-locus atopic dermatitis risk signal from the Budu-Aggr...	Allergy & Atopic Disease	Skin	Moderate
rs6887695	IL12B Upstream regulatory	Upstream regulatory variant ~60 kb 5' of IL12B, forming the canonical two-SNP...	Psoriasis & Spondyloarthropathy	Skin	Strong
rs7746808	IL23A	Intergenic variant near the IL23A locus associated with psoriasis and psoriat...	Psoriasis & Spondyloarthropathy	Skin	Emerging
rs187080438	CTSS Cathepsin S antigen presentation variant	Intronic variant in the CTSS locus associated with elevated atopic dermatitis...	Allergy & Atopic Disease	Skin	Moderate
rs2967677	CERS4 Ceramide synthase 4 locus variant	A 3'UTR variant in the CERS4/NFILZ locus on chromosome 19 associated with ato...	Allergy & Atopic Disease	Skin	Strong
rs7125552	EMSY EMSY Haplotype Partner Allergy Variant	Intronic EMSY variant that defines the high-risk haplotype at 11q13.5; the G ...	Allergy & Atopic Disease	Skin	Moderate
rs7927894	EMSY	Regulatory variant near the EMSY/C11orf30 locus; T allele increases EMSY expr...	Allergy & Atopic Disease	Skin	Strong