Tag
Atherosclerosis
39 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1024611 | CCL2 A-2518G | Promoter variant that increases CCL2 (MCP-1) transcription, amplifying monocy... | Vascular Inflammation & Remodeling | Moderate | |
| rs1044317 | ABCG1 ABCG1 3'UTR variant | 3'UTR variant in ABCG1 that may reduce transporter expression, impairing chol... | Cholesterol & Lipoproteins | Moderate | |
| rs11556924 | ZC3HC1 R363H | Missense variant in ZC3HC1/NIPA altering cell cycle regulation; the T (His363... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs12487736 | SCAP SCAP Val798Ile | Missense variant in the SCAP cholesterol-sensor gene (Val798Ile) | Atherogenic Lipoproteins | Moderate | |
| rs1378577 | ABCG1 ABCG1 ischemic stroke variant | Regulatory variant ~2kb upstream of ABCG1 that modulates transporter expressi... | Atherogenic Lipoproteins | Moderate | |
| rs13900 | CCL2 CCL2 3'UTR variant | 3'UTR variant that increases CCL2 mRNA stability via enhanced HuR binding, el... | Vascular Inflammation & Remodeling | Moderate | |
| rs1800787 | FGB -148C>T | Upstream promoter variant in fibrinogen beta chain that elevates circulating ... | Coagulation & Clotting Factors | Strong | |
| rs13324341 | MRAS | Intronic MRAS variant that creates a MEF2 transcription factor binding site i... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs17222842 | ALOX5AP ALOX5AP variant (SG13S35) | Intronic ALOX5AP haplotype tag; the common G allele marks the HapB cardiovasc... | Vascular Inflammation & Remodeling | Moderate | |
| rs1800790 | FGB -455G>A | Promoter variant in the fibrinogen beta-chain gene that upregulates FGB trans... | Coagulation & Clotting Factors | Strong | |
| rs1333040 | CDKN2B-AS1 | 9p21 locus variant in the ANRIL long non-coding RNA gene associated with intr... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs1457043 | CYP7A1 | Intronic variant in CYP7A1 that tags a haplotype block influencing cholestero... | Cholesterol & Lipoproteins | Moderate | |
| rs1360590 | CDKN2BAS | Intronic variant in ANRIL at the 9p21.3 locus — the shared susceptibility reg... | Coronary Artery Disease & Atherosclerosis | Moderate | |
| rs1799987 | CCR5 CCR5 Promoter -2459A>G | Regulatory variant in the CCR5 promoter that reduces CCR5 expression by ~45%;... | Vascular Inflammation & Remodeling | Moderate | |
| rs17228212 | SMAD3 | Intronic variant in the TGF-beta signaling gene SMAD3 associated with vascula... | Coronary Artery Disease & Atherosclerosis | Moderate | |
| rs2234714 | ABCG1 ABCG1 promoter variant | Intronic ABCG1 variant near the promoter region; homozygous carriers of the m... | Cholesterol & Lipoproteins | Emerging | |
| rs1746048 | CXCL12 | Regulatory variant 80 kb downstream of CXCL12 on chromosome 10q11; the T alle... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs1927911 | TLR4 | Intronic TLR4 variant in the innate immune receptor gene; the A allele associ... | Vascular Inflammation & Remodeling | Moderate | |
| rs17465637 | MIA3 | Intronic variant in MIA3/TANGO1 affecting collagen secretion and vascular smo... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs2237583 | PON1 PON1 intron variant | Intronic PON1 variant that modulates arylesterase activity of the HDL-bound a... | Vascular Inflammation & Remodeling | Moderate | |
| rs5174 | LRP8 LRP8 R952Q | Missense variant in LRP8 (ApoER2) replacing arginine with glutamine at positi... | Atherogenic Lipoproteins | Moderate | |
| rs17514846 | FURIN | Intronic regulatory variant modulating FURIN expression via allele-specific D... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs55714927 | ASGR1 ASGR1 K89K | Synonymous coding variant (Lys89Lys) in the asialoglycoprotein receptor 1 gen... | Atherogenic Lipoproteins | Strong | |
| rs17576 | MMP9 MMP9 Q279R | Missense variant in the MMP9 fibronectin type II domain affecting matrix meta... | Coronary Artery Disease & Atherosclerosis | Moderate | |
| rs20455 | KIF6 Trp719Arg | Missense variant in kinesin family member 6; the Arg allele was associated wi... | Coronary Artery Disease & Atherosclerosis | Moderate | |
| rs2298566 | SNX19 | Missense variant in sorting nexin 19; the A allele was associated with elevat... | Coronary Artery Disease & Atherosclerosis | Moderate | |
| rs3093059 | CRP -757T>C | Promoter variant that elevates baseline C-reactive protein levels, increasing... | Vascular Inflammation & Remodeling | Strong | |
| rs3900940 | MYH15 T1105A | Missense variant in MYH15 encoding a Thr1105Ala substitution in myosin heavy ... | Cardiomyopathy & Structural Heart | Emerging | |
| rs3850641 | TNFSF4 TNFSF4 (OX40L) Intron 1 Variant | Intronic variant in TNFSF4 (OX40 ligand); homozygous G carriers show approxim... | Coronary Artery Disease & Atherosclerosis | Moderate | |
| rs5051 | AGT G-6A | Promoter variant that increases angiotensinogen gene transcription, raising p... | Blood Pressure & Hypertension | Strong | |
| rs705379 | PON1 PON1 promoter -108C>T | Promoter polymorphism that controls PON1 gene expression — the T allele (A on... | Vascular Inflammation & Remodeling | Strong | |
| rs3918242 | MMP9 MMP9 C-1562T | Promoter variant that disrupts an SP1 transcription factor binding site, incr... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs854555 | PON1 PON1 3'UTR variant | Intronic/downstream PON1 haplotype-tagging variant associated with PON1 activ... | Vascular Inflammation & Remodeling | Emerging | |
| rs4888378 | CFDP1 | Intronic CFDP1 locus variant that regulates BCAR1 expression in vascular tiss... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs4977574 | CDKN2B-AS1 9p21.3 | 9p21.3 CAD risk signal in ANRIL; G allele elevates coronary artery disease ri... | Coronary Artery Disease & Atherosclerosis | Established | |
| rs501120 | CXCL12 | Regulatory variant ~80 kb downstream of CXCL12 (SDF-1) associated with elevat... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs56062135 | SMAD3 SMAD3 intronic variant | Intronic SMAD3 variant tagging the CAD-protective haplotype where the T allel... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs7025486 | DAB2IP DAB2IP intron variant | Intronic variant in DAB2IP associated with increased risk of abdominal aortic... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs57137919 | ABCG1 | ABCG1 promoter variant that reduces transporter expression, impairing macroph... | Triglycerides & Fatty Acids | Moderate |