Tag

Bacterial Sensing

8 genetic variants with this tag.

RSID	Gene	Description	Category
rs104895431	NOD2	Rare NOD2 missense variant (Ser431Leu) that reduces NF-κB activation in respo...	IBD & Mucosal Immunity	Bacterial Sensing	Strong
rs104895467	NOD2 NOD2 N852S	Rare NOD2 missense variant (Asn852Ser) that impairs innate immune sensing of ...	IBD & Mucosal Immunity	Bacterial Sensing	Strong
rs10759931	TLR4 -2604G>A	Promoter variant in Toll-like receptor 4 that drives higher TLR4 expression a...	Innate Immunity & Infection Defense	Bacterial Sensing	Moderate
rs1898830	TLR2	Intronic TLR2 variant that modulates innate immune signaling intensity; G all...	Innate Immunity & Infection Defense	Bacterial Sensing	Moderate
rs2066844	NOD2 R702W	Missense variant in the NOD2 gene that increases Crohn's disease risk, partic...	IBD & Mucosal Immunity	Bacterial Sensing	Established
rs2066845	NOD2 G908R	NOD2 bacterial sensor variant that increases Crohn's disease risk by impairin...	IBD & Mucosal Immunity	Bacterial Sensing	Established
rs2066847	NOD2 3020insC (1007fs)	The most important Crohn's disease risk variant worldwide — a frameshift inse...	IBD & Mucosal Immunity	Bacterial Sensing	Established
rs3796508	TLR6 Val327Met	Missense variant substituting valine with methionine at position 327 of TLR6,...	Innate Immunity & Infection Defense	Bacterial Sensing	Emerging