Tag
Blood Thinners
20 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10455872 | LPA | Intronic variant strongly associated with elevated lipoprotein(a) levels and ... | Atherogenic Lipoproteins | Established | |
| rs121909548 | SERPINC1 Cambridge II (A384S) | Missense variant in antithrombin (SERPINC1) that impairs heparin-catalyzed th... | Von Willebrand & Anticoagulant Proteins | Strong | |
| rs121909567 | SERPINC1 Budapest 3 (Leu131Phe) | Pathogenic missense in antithrombin III; the A allele causes type II heparin-... | Von Willebrand & Anticoagulant Proteins | Established | |
| rs121918475 | PROS1 Q279X | Pathogenic nonsense variant in protein S that eliminates the anticoagulant co... | Von Willebrand & Anticoagulant Proteins | Established | |
| rs1799963 | F2 G20210A | Second most common inherited thrombophilia; the A allele raises prothrombin l... | Coagulation & Clotting Factors | Established | |
| rs121918476 | PROS1 Arg561Trp | Pathogenic PROS1 missense variant in the SHBG-like domain that impairs protei... | Von Willebrand & Anticoagulant Proteins | Strong | |
| rs1800595 | F5 HR2 haplotype (H1299R / R2) | Factor V HR2 haplotype — a missense variant that mildly impairs the anticoagu... | Coagulation & Clotting Factors | Moderate | |
| rs2288904 | SLC44A2 R154Q | Missense variant that impairs platelet-neutrophil binding; carriers of the Q1... | Von Willebrand & Anticoagulant Proteins | Strong | |
| rs3798220 | LPA Ile4399Met (I4399M) | Missense variant in the protease-like domain of apolipoprotein(a) causing mar... | Atherogenic Lipoproteins | Strong | |
| rs1142345 | TPMT *3C | No-function variant causing deficient thiopurine methylation; most common TPM... | Pharmacogenomics | Established | |
| rs369504169 | PROC p.Arg42His (c.125G>A) | Rare missense variant in the PROC gene encoding protein C; the A allele subst... | Von Willebrand & Anticoagulant Proteins | Strong | |
| rs387906674 | PROS1 R355C | Rare pathogenic missense variant in protein S causing hereditary type III pro... | Von Willebrand & Anticoagulant Proteins | Strong | |
| rs387906675 | PROS1 Y234C | Pathogenic missense variant in the vitamin K-dependent anticoagulant gene PRO... | Von Willebrand & Anticoagulant Proteins | Established | |
| rs1800460 | TPMT *3B | Decreased-function variant causing reduced thiopurine methylation; pairs with... | Pharmacogenomics | Established | |
| rs5186 | AGTR1 A1166C | 3' UTR variant in angiotensin II type 1 receptor affecting blood pressure reg... | Blood Pressure & Hypertension | Moderate | |
| rs2108622 | CYP4F2 V433M (*3) | Reduces vitamin K metabolism, requiring higher warfarin doses to achieve anti... | Pharmacogenomics | Established | |
| rs4244285 | CYP2C19 *2 | No-function CYP2C19 variant affecting PPIs, clopidogrel, and some antidepress... | Pharmacogenomics | Established | |
| rs4986893 | CYP2C19 *3 | No-function CYP2C19 stop-gain variant — second most common loss-of-function a... | Pharmacogenomics | Established | |
| rs6025 | F5 Leiden | Factor V Leiden - blood clotting disorder affecting thrombosis risk | Pharmacogenomics | Established | |
| rs9923231 | VKORC1 -1639G>A | Warfarin sensitivity - determines initial dosing | Pharmacogenomics | Established |