Tag

Gut Barrier

9 genetic variants with this tag.

RSID	Gene	Description	Category
rs1050152	SLC22A4 OCTN1 L503F	Missense variant in SLC22A4 encoding the organic cation/ergothioneine transpo...	Allergy & Atopic Disease	Gut Barrier	Strong
rs10758669	JAK2	Intergenic variant near JAK2 that increases JAK2 expression and JAK-STAT sign...	IBD & Mucosal Immunity	Gut Barrier	Strong
rs11229030	PRG2	Intergenic tag SNP in the PRG2/PRG3 eosinophil major basic protein gene clust...	Allergy & Atopic Disease	Gut Barrier	Moderate
rs2108225	SLC26A3 SLC26A3 Ulcerative Colitis Susceptibility Variant	Regulatory variant at the SLC26A3 locus associated with ulcerative colitis su...	Autoimmune Tolerance & T-Cell Regulation	Gut Barrier	Moderate
rs2230926	TNFAIP3 F127C	Missense variant in the A20 ubiquitin-editing enzyme that weakens NF-kB negat...	TNF, NF-kB & Inflammatory Cytokines	Gut Barrier	Strong
rs1800972	DEFB1 DEFB1 -44C>G	Promoter variant in the beta-defensin 1 gene that reduces constitutive hBD-1 ...	IBD & Mucosal Immunity	Gut Barrier	Moderate
rs2066847	NOD2 3020insC (1007fs)	The most important Crohn's disease risk variant worldwide — a frameshift inse...	IBD & Mucosal Immunity	Gut Barrier	Established
rs2631367	SLC22A5 OCTN2 -207C>G	Promoter variant in SLC22A5 (OCTN2) that reduces carnitine transporter expres...	IBD & Mucosal Immunity	Gut Barrier	Strong
rs5029939	TNFAIP3	Intronic variant near TNFAIP3 that tags a 6q23 haplotype strongly associated ...	TNF, NF-kB & Inflammatory Cytokines	Gut Barrier	Strong