Tag

Psoriasis

41 genetic variants with this tag.

RSID	Gene	Description	Category
rs10045431	IL12B	Upstream tagging SNP at the IL12B locus that marks the Th1/Th17 risk haplotyp...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs10050860	ERAP1 D575N	Missense variant (Asp575Asn) in the ERAP1 catalytic domain that modestly redu...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs10794648	IFNLR1/GRHL3	Intergenic regulatory variant near IFNLR1 that contacts GRHL3 via chromatin l...	Interferon Signaling & Systemic Autoimmune	Psoriasis	Moderate
rs11652075	CARD14 CARD14 Arg820Trp (R820W)	Missense variant in the keratinocyte NF-κB scaffold protein CARD14 that modes...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs12188300	IL12B	Near-gene variant at the IL12B locus associated with psoriasis risk through a...	Psoriasis & Spondyloarthropathy	Psoriasis	Moderate
rs1217414	PTPN22	Intronic PTPN22 variant independently associated with psoriasis and ankylosin...	Autoimmune Tolerance & T-Cell Regulation	Psoriasis	Moderate
rs12191877	HLA-C Tag for *06:02	Tag SNP for HLA-C*06:02, the strongest genetic risk factor for psoriasis, det...	Psoriasis & Spondyloarthropathy	Psoriasis	Established
rs12883343	NFKBIA NFKBIA/IkB-alpha variant	Regulatory variant near NFKBIA that specifically elevates risk for psoriatic ...	Psoriasis & Spondyloarthropathy	Psoriasis	Moderate
rs12720356	TYK2 Ile684Ser	A missense variant in the TYK2 pseudokinase (JH2) domain that partially impai...	Autoimmune Tolerance & T-Cell Regulation	Psoriasis	Strong
rs13190932	TRAF3IP2 R74W	Missense variant in the IL-17 adaptor Act1 (Arg74Trp) that is the primary GWA...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs13196377	TRAF3IP2 Intronic haplotype member	Intronic tagging variant in the TRAF3IP2/TRAF3IP2-AS1 locus that distinguishe...	Psoriasis & Spondyloarthropathy	Psoriasis	Moderate
rs1799724	TNF -857C>T	TNF promoter variant that disrupts an OCT-1 binding site, altering TNF-alpha ...	TNF, NF-kB & Inflammatory Cytokines	Psoriasis	Moderate
rs13210247	TRAF3IP2	Intronic variant in the TRAF3IP2 locus that lies within the antisense lncRNA ...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs11465804	IL23R	Intronic IL23R variant in strong linkage disequilibrium with the functional R...	IBD & Mucosal Immunity	Psoriasis	Strong
rs12044149	IL23R	Regulatory variant upstream of the IL-23 receptor gene more strongly associat...	IBD & Mucosal Immunity	Psoriasis	Strong
rs17728338	TNIP1 TNIP1/ABIN1 variant	Intergenic regulatory variant near TNIP1 whose A allele reduces ABIN1-mediate...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs2066808	IL23A	Intronic variant near IL23A encoding the IL-23 p19 subunit; G allele increase...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs2201841	IL23R	Intronic variant in the IL-23 receptor gene associated with increased risk of...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs2256774	IL2RA	Intronic IL2RA variant that modulates soluble IL-2RA shedding and Treg signal...	Autoimmune Tolerance & T-Cell Regulation	Psoriasis	Moderate
rs2546890	LOC285626 LOC285626 rs2546890	Regulatory variant upstream of IL12B associated with increased risk of multip...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs26653	ERAP1	Missense variant (Arg127Pro) in ERAP1 that subtly alters ER peptide trimming ...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs27044	ERAP1 Gln730Glu	Missense variant in the ERAP1 C-terminal regulatory domain modulating peptide...	Psoriasis & Spondyloarthropathy	Psoriasis	Moderate
rs27524	ERAP1	Intronic ERAP1 variant that increases expression, raising psoriasis risk spec...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs30187	ERAP1 K528R	Missense variant reducing ERAP1 aminopeptidase activity, increasing ankylosin...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs3212227	IL12B 3'UTR	IL12B 3'-UTR variant forming the canonical two-SNP psoriasis risk haplotype w...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs3213094	IL12B Promoter-region	Intronic IL12B variant in linkage with the promoter-regulatory haplotype; T a...	Psoriasis & Spondyloarthropathy	Psoriasis	Moderate
rs33980500	TRAF3IP2 D10N	Missense variant in Act1 that abolishes IL-17 signaling by disrupting TRAF6 b...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs3805435	TNIP1	Intronic variant in the GPX3/TNIP1 regulatory locus on chromosome 5; the C al...	Psoriasis & Spondyloarthropathy	Psoriasis	Moderate
rs41298997	IKBKE	Intronic variant in IKBKE (IKK-epsilon) associated with psoriasis susceptibil...	Psoriasis & Spondyloarthropathy	Psoriasis	Moderate
rs35018800	TYK2 TYK2 Ala928Val	A rare missense variant in the TYK2 pseudokinase (JH2) domain that partially ...	Autoimmune Tolerance & T-Cell Regulation	Psoriasis	Strong
rs3789604	RSBN1	Synonymous RSBN1 variant that tags a PTPN22 locus haplotype independently ass...	Autoimmune Tolerance & T-Cell Regulation	Psoriasis	Moderate
rs582757	TNFAIP3 TNFAIP3 A20 regulatory variant	Intronic regulatory variant in TNFAIP3 — the primary NF-kB brake gene — with ...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs559406	PTPN2	Intronic PTPN2 variant whose G allele reduces T-cell protein tyrosine phospha...	Autoimmune Tolerance & T-Cell Regulation	Psoriasis	Moderate
rs610604	TNFAIP3	Intronic variant in TNFAIP3 whose G allele is the primary psoriasis susceptib...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs61751629	CARD14 Glu422Lys	Rare missense variant in the keratinocyte NF-κB scaffold protein CARD14 that ...	Psoriasis & Spondyloarthropathy	Psoriasis	Emerging
rs6887695	IL12B Upstream regulatory	Upstream regulatory variant ~60 kb 5' of IL12B, forming the canonical two-SNP...	Psoriasis & Spondyloarthropathy	Psoriasis	Strong
rs492602	FUT2 FUT2 secretor status proxy	A synonymous FUT2 proxy variant in strong LD with the W143X nonsense allele (...	IBD & Mucosal Immunity	Psoriasis	Strong
rs7152376	NFKBIA	Regulatory variant upstream of NFKBIA that specifically elevates risk of psor...	Psoriasis & Spondyloarthropathy	Psoriasis	Moderate
rs7540214	IFNLR1 IFNLR1 variant	Intronic variant in the interferon lambda receptor 1 gene that elevates PsA r...	Psoriasis & Spondyloarthropathy	Psoriasis	Moderate
rs7746808	IL23A	Intergenic variant near the IL23A locus associated with psoriasis and psoriat...	Psoriasis & Spondyloarthropathy	Psoriasis	Emerging
rs7517847	IL23R	Intronic IL23R variant in which the T allele increases susceptibility to Croh...	IBD & Mucosal Immunity	Psoriasis	Strong