Tag
Psoriasis
30 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10045431 | IL12B | Upstream tagging SNP at the IL12B locus; the C allele is associated with incr... | Psoriasis & Spondyloarthropathy | Strong | |
| rs10050860 | ERAP1 D575N | Missense variant (Asp575Asn) in ERAP1; the protective T allele (Asn575) is co... | Psoriasis & Spondyloarthropathy | Strong | |
| rs10794648 | IFNLR1/GRHL3 | Intergenic regulatory variant near IFNLR1 that contacts GRHL3 via chromatin l... | Interferon Signaling & Systemic Autoimmune | Moderate | |
| rs11652075 | CARD14 CARD14 Arg820Trp (R820W) | Missense variant in the keratinocyte NF-κB scaffold protein CARD14 that modes... | Psoriasis & Spondyloarthropathy | Strong | |
| rs1217414 | PTPN22 | Intronic PTPN22 variant independently associated with psoriasis and ankylosin... | Autoimmune Tolerance & T-Cell Regulation | Moderate | |
| rs12191877 | HLA-C Tag for *06:02 | Tag SNP for HLA-C*06:02, the strongest genetic risk factor for psoriasis, det... | Psoriasis & Spondyloarthropathy | Established | |
| rs13190932 | TRAF3IP2 R74W | Missense variant in the IL-17 adaptor Act1 (Arg74Trp) that is the primary GWA... | Psoriasis & Spondyloarthropathy | Strong | |
| rs12720356 | TYK2 Ile684Ser | A missense variant in the TYK2 pseudokinase (JH2) domain that partially impai... | Autoimmune Tolerance & T-Cell Regulation | Strong | |
| rs13196377 | TRAF3IP2 Intronic haplotype member | Intronic tagging variant in the TRAF3IP2/TRAF3IP2-AS1 locus that distinguishe... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs13210247 | TRAF3IP2 | Intronic variant in the TRAF3IP2 locus that lies within the antisense lncRNA ... | Psoriasis & Spondyloarthropathy | Strong | |
| rs1799724 | TNF -857C>T | TNF promoter variant that disrupts an OCT-1 binding site, altering TNF-alpha ... | TNF, NF-kB & Inflammatory Cytokines | Moderate | |
| rs11465804 | IL23R | Intronic IL23R variant in strong linkage disequilibrium with the functional R... | IBD & Mucosal Immunity | Strong | |
| rs12044149 | IL23R | Regulatory variant upstream of the IL-23 receptor gene more strongly associat... | IBD & Mucosal Immunity | Strong | |
| rs17728338 | TNIP1 TNIP1/ABIN1 variant | Intergenic regulatory variant near TNIP1 whose A allele reduces ABIN1-mediate... | Psoriasis & Spondyloarthropathy | Strong | |
| rs2201841 | IL23R | Intronic variant in the IL-23 receptor gene associated with increased risk of... | Psoriasis & Spondyloarthropathy | Strong | |
| rs2256774 | IL2RA | Intronic IL2RA variant independently associated with psoriasis susceptibility | Autoimmune Tolerance & T-Cell Regulation | Moderate | |
| rs2546890 | LOC285626 LOC285626 rs2546890 | Regulatory variant upstream of IL12B associated with increased risk of multip... | Psoriasis & Spondyloarthropathy | Strong | |
| rs27524 | ERAP1 | Intronic ERAP1 variant that increases expression, raising psoriasis risk spec... | Psoriasis & Spondyloarthropathy | Strong | |
| rs30187 | ERAP1 K528R | Missense variant reducing ERAP1 aminopeptidase activity, increasing ankylosin... | Psoriasis & Spondyloarthropathy | Strong | |
| rs3212227 | IL12B 3'UTR | IL12B 3'-UTR variant forming the canonical two-SNP psoriasis risk haplotype w... | Psoriasis & Spondyloarthropathy | Strong | |
| rs3213094 | IL12B Promoter-region | Intronic IL12B variant in linkage with the promoter-regulatory haplotype; T a... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs33980500 | TRAF3IP2 D10N | Missense variant in Act1 that abolishes IL-17 signaling by disrupting TRAF6 b... | Psoriasis & Spondyloarthropathy | Strong | |
| rs3805435 | TNIP1 | Intronic variant in the GPX3/TNIP1 regulatory locus on chromosome 5; the C al... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs41298997 | IKBKE | Intronic variant in IKBKE (IKK-epsilon) associated with psoriasis susceptibil... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs35018800 | TYK2 TYK2 Ala928Val | A rare missense variant that partially reduces TYK2 catalytic activity, confe... | Autoimmune Tolerance & T-Cell Regulation | Strong | |
| rs582757 | TNFAIP3 TNFAIP3 A20 regulatory variant | Intronic regulatory variant in TNFAIP3 — the primary NF-kB brake gene — with ... | Psoriasis & Spondyloarthropathy | Strong | |
| rs610604 | TNFAIP3 | Intronic variant in TNFAIP3 whose G allele is the primary psoriasis susceptib... | Psoriasis & Spondyloarthropathy | Strong | |
| rs61751629 | CARD14 Glu422Lys | Rare missense variant in the keratinocyte NF-κB scaffold protein CARD14 that ... | Psoriasis & Spondyloarthropathy | Emerging | |
| rs7152376 | NFKBIA | Regulatory variant upstream of NFKBIA that specifically elevates risk of psor... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs7517847 | IL23R | Intronic IL23R variant in which the T allele increases susceptibility to Croh... | IBD & Mucosal Immunity | Strong |