rs10156191 — AOC1 Thr16Met

DAO structural variant affecting enzyme activity and histamine degradation

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DAO Structural Variant - When the Enzyme Itself Is Altered

While rs2052129 affects how much DAO enzyme your body makes, the Thr16Met 11 Threonine to methionine at position 16 variant (rs10156191) changes the actual structure of the enzyme protein. This is a missense mutation 22 A missense mutation changes one amino acid to another in the resulting protein that substitutes threonine with methionine at position 16, potentially altering the enzyme's ability to bind and degrade histamine.

Clinical Significance

This variant is frequently studied alongside other AOC1 variants to determine overall DAO haplotype status. The variant is notably more common in African populations (T allele ~51%) compared to East Asian populations (~11%).

What This Means for You

If you carry the T allele here, evaluate your overall DAO status by considering other AOC1 variants together. Practical dietary strategies remain the same: fresh foods, low-histamine choices, and DAO supplements with meals if needed.

Nutrient Interactions

histamine altered_metabolism
copper increased_need

Genotype Interpretations

What each possible genotype means for this variant.

CC Normal DAO Structure Normal

Normal DAO structure

Normal DAO enzyme structure at this position. About 55% of Europeans share this genotype.

CT One Structural Variant Intermediate

One structural DAO variant

You carry one structural variant that may reduce DAO activity. Combined with other DAO variants, this affects overall histamine clearance in the gut. About 37% of Europeans share this genotype.

TT Reduced DAO Structure Reduced

Reduced DAO structure/function

Two structural variants reducing DAO function. About 8% of Europeans have this genotype. Consider low-histamine dietary approaches, especially if you carry variants at other DAO positions.