Tag

Detoxification

37 genetic variants with this tag.

RSID	Gene	Description	Category
rs1799750	MMP1 1G/2G	Promoter polymorphism affecting MMP1 expression and collagen degradation rate...	Skin & Eyes	Skin, Hair & Pigmentation Cardiovascular Diet	Strong
rs4646903	CYP1A1 *2A (MspI, T3801C)	Regulatory variant in the 3'-flanking region of CYP1A1 that increases gene in...	Dental & Oral Health	Detoxification Phase I Xenobiotics	Moderate
rs662	PON1 Q192R	Affects paraoxonase-1 enzyme activity for detoxifying organophosphates and pr...	Heart & Inflammation	Cardiovascular Detoxification Cholesterol	Moderate
rs6721961	NFE2L2	Promoter variant reducing NRF2 transcriptional activity by >50%, impairing th...	Longevity & Aging	Oxidative Stress Antioxidants Detoxification	Moderate
rs4680	COMT Val158Met	Dopamine/catecholamine breakdown — affects stress response and methyl donor t...	Methylation & Detox	Methylation Neurotransmitters Detoxification	Established
rs234706	CBS C699T	Common synonymous variant in the CBS gene associated with reduced cardiovascu...	Methylation & Detox	Methylation Cardiovascular Folate	Moderate
rs671	ALDH2 *2	Alcohol metabolism - flush reaction and cancer risk	Pharmacogenomics	Drug Metabolism Diet Detoxification	Established
rs2066853	AHR Arg554Lys	Aryl hydrocarbon receptor variant in the transactivation domain that alters A...	Hormones & Sleep	Sleep Circadian Caffeine	Moderate
rs2470890	CYP1A2 Asn516= (exon 7)	Synonymous variant in CYP1A2 exon 7 in linkage disequilibrium with the *1F hi...	Cancer Risk	Cancer Risk Carcinogen Metabolism Detoxification	Strong
rs819147	AHCY	Regulatory variant affecting S-adenosylhomocysteine hydrolase expression, inf...	Methylation & Detox	Methylation Homocysteine Cardiovascular	Moderate
rs2052129	AOC1 (DAO) promoter variant	Histamine breakdown in gut - reduced activity means dietary histamine accumul...	Methylation & Detox	Histamine Food Sensitivity Detoxification	Strong
rs10156191	AOC1 (DAO) Thr16Met	DAO structural variant affecting enzyme activity and histamine degradation	Methylation & Detox	Histamine Food Sensitivity Detoxification	Strong
rs1049793	AOC1 (DAO) His645Asp	DAO structural variant near the catalytic domain affecting histamine degradation	Methylation & Detox	Histamine Food Sensitivity Detoxification	Strong
rs13181	ERCC2 Lys751Gln	Missense variant in the XPD helicase that reduces nucleotide excision repair ...	Longevity & Aging	DNA Repair Longevity Aging	Strong
rs1050891	HNMT 3'UTR variant	Histamine breakdown in blood and tissues - uses methyl groups from SAM	Methylation & Detox	Histamine Methylation Detoxification	Moderate
rs11558538	HNMT Thr105Ile	HNMT structural variant - reduces enzyme stability and histamine clearance in...	Methylation & Detox	Histamine Methylation Detoxification	Strong
rs1799983	NOS3 Glu298Asp	Nitric oxide production - reduced activity increases cardiovascular risk and ...	Methylation & Detox	Cardiovascular Nitric Oxide Detoxification	Established
rs2070744	NOS3 T-786C promoter	NOS3 expression - controls how much eNOS enzyme is produced for nitric oxide ...	Methylation & Detox	Cardiovascular Nitric Oxide Detoxification	Strong
rs1801280	NAT2 I114T	Phase II detoxification - acetylation of aromatic amines and certain medications	Methylation & Detox	Detoxification Acetylation Drug Metabolism	Established
rs1799930	NAT2 R197Q	Slow acetylator variant affecting Phase II detoxification capacity	Methylation & Detox	Detoxification Acetylation Drug Metabolism	Established
rs1208	NAT2 R268K	NAT2 acetylation speed tag SNP - marks rapid vs slow acetylator haplotypes	Methylation & Detox	Detoxification Acetylation Drug Metabolism	Established
rs4880	SOD2 Val16Ala	Primary mitochondrial antioxidant enzyme - variant reduces superoxide detoxif...	Methylation & Detox	Detoxification Oxidative Stress Antioxidants	Strong
rs1050450	GPX1 Pro198Leu	Selenium-dependent antioxidant enzyme that neutralizes hydrogen peroxide; the...	Methylation & Detox	Detoxification Oxidative Stress Selenium	Strong
rs1695	GSTP1 Ile105Val	Phase II detoxification enzyme that conjugates glutathione to carcinogens, dr...	Methylation & Detox	Detoxification Glutathione Phase II	Strong
rs28929474	SERPINA1 Z allele (E342K)	Most common alpha-1 antitrypsin deficiency variant causing protein misfolding...	Nutrition & Metabolism	Detoxification Lung Health Liver Disease	Established
rs1138272	GSTP1 Ala114Val	Second functional variant in glutathione S-transferase Pi 1, reducing enzyme ...	Methylation & Detox	Detoxification Glutathione Phase II	Moderate
rs366631	GSTM1 Tag SNP for gene deletion	Tag SNP proxy for GSTM1 gene deletion status — the most common pharmacogenomi...	Methylation & Detox	Detoxification Glutathione Phase II	Strong
rs1800566	NQO1 Pro187Ser (C609T)	Phase II detoxification enzyme that reduces quinones and recycles CoQ10 to it...	Methylation & Detox	Detoxification Phase II Oxidative Stress	Strong
rs1048943	CYP1A1 Ile462Val (*2C)	Phase I detoxification enzyme that activates polycyclic aromatic hydrocarbons...	Methylation & Detox	Detoxification Phase I Xenobiotics	Strong
rs1056836	CYP1B1 Leu432Val	Phase I detoxification enzyme that hydroxylates estradiol to potentially geno...	Methylation & Detox	Detoxification Phase I Estrogen Metabolism	Moderate
rs1001179	CAT -262C>T	Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...	Methylation & Detox	Detoxification Antioxidants Oxidative Stress	Strong
rs1229984	ADH1B His48Arg	ADH1B variant encoding a ~100x faster alcohol dehydrogenase enzyme, causing r...	Brain & Mental Health	Addiction Alcohol Cancer Risk	Established
rs71748309	GSTT1 Null (Gene Deletion)	Complete deletion of the GSTT1 gene eliminating glutathione conjugation capac...	Methylation & Detox	Detoxification Glutathione Phase II	Strong
rs2066702	ADH1B Arg370Cys	ADH1B*3 variant encoding a superactive alcohol dehydrogenase found almost exc...	Brain & Mental Health	Addiction Alcohol Detoxification	Strong
rs1693482	ADH1C Arg272Gln (ADH1C1/2)	ADH1C variant defining the fast (ADH1C1, Arg272) vs slow (ADH1C2, Gln272) a...	Brain & Mental Health	Addiction Alcohol Cancer Risk	Strong
rs61735836	FTCD	Missense variant in the FTCD enzyme that impairs one-carbon unit transfer fro...	Nutrition & Metabolism	Methylation Folate B Vitamins	Strong
rs234709	CBS	Intronic CBS variant that tags the CBS locus in GWAS studies; associated with...	Nutrition & Metabolism	Methylation Homocysteine B Vitamins	Moderate