Tag

Depression

23 genetic variants with this tag.

RSID	Gene	Description	Category
rs1006737	CACNA1C	L-type calcium channel gene variant affecting mood regulation, emotional proc...	Mood & Behavior	Depression	Strong
rs10514299	TMEM161B-MEF2C TMEM161B-MEF2C intergenic variant	Intronic variant near the MEF2C transcription factor locus associated with in...	Mood & Behavior	Depression	Strong
rs10786831	SORCS3 SORCS3 Depression Variant	Intronic variant in the neurotrophin sorting receptor SORCS3, the top GWAS hi...	Mood & Behavior	Depression	Strong
rs12624433	SLC12A5 KCC2 Chloride Transport	Intronic variant in SLC12A5 reducing KCC2 potassium-chloride cotransporter fu...	Mood & Behavior	Depression	Moderate
rs1360780	FKBP5 Intronic C>T	Co-chaperone of the glucocorticoid receptor that regulates cortisol feedback ...	Mood & Behavior	Depression	Strong
rs1743963	SGK1	Intronic SGK1 variant associated with depression susceptibility in coronary h...	Blood Pressure & Hypertension	Depression	Emerging
rs1387923	NTRK2 NTRK2/TrkB 3'UTR variant	3' UTR variant in the TrkB receptor gene affecting NTRK2 expression; associat...	Mood & Behavior	Depression	Moderate
rs1545843	SLC6A15 SLC6A15 depression risk variant	Intronic variant reducing SLC6A15 expression in hippocampus; AA carriers show...	Mood & Behavior	Depression	Strong
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Appetite & Obesity	Depression	Moderate
rs139315125	PER3 H417R	Rare PER3 missense variant that co-occurs on the FASPS3 haplotype with Pro415...	Hormones & Sleep	Depression	Strong
rs150812083	PER3 PER3 Pro415Ala (FASPS3)	Rare PER3 missense variant that destabilizes the circadian clock protein, sho...	Hormones & Sleep	Depression	Strong
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Appetite & Obesity	Depression	Strong
rs2371365	PCLO PCLO Presynaptic Scaffold	Intronic variant in the presynaptic scaffold gene PCLO linked to altered mono...	Mood & Behavior	Depression	Moderate
rs2522833	PCLO Ser4814Ala	Missense variant in the C2A calcium-binding domain of presynaptic scaffolding...	Mood & Behavior	Depression	Moderate
rs2568958	NEGR1 NEGR1 depression/BMI variant	Intergenic tag SNP near NEGR1 associated with elevated BMI and major depressi...	Mood & Behavior	Depression	Strong
rs34579341	NEGR1 NEGR1 Neuronal Growth Regulator	Intronic tag SNP in NEGR1 affecting neuronal cell adhesion, hippocampal neuro...	Mood & Behavior	Depression	Strong
rs35936514	LHPP LHPP depression risk variant	Intronic/3'UTR variant in LHPP, a histidine phosphatase essential for stress ...	Mood & Behavior	Depression	Strong
rs41423247	NR3C1 BclI	Intronic glucocorticoid receptor variant affecting cortisol sensitivity and s...	Mood & Behavior	Depression	Strong
rs4570625	TPH2 G-703T	Promoter variant affecting brain serotonin synthesis enzyme; influences emoti...	Mood & Behavior	Depression	Moderate
rs4702	FURIN proBDNF Processing Variant	A 3'UTR regulatory variant where the G allele creates a miR-338-3p binding si...	Mood & Behavior	Depression	Moderate
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Depression	Strong
rs6323	MAOA R297R	X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans...	Mood & Behavior	Depression	Strong
rs2675703	OPN4	Missense variant (Pro10Leu) in melanopsin, the photopigment driving circadian...	Hormones & Sleep	Depression	Emerging