Fluoropyrimidine Toxicity

5 genetic variants with this tag.

RSID	Gene	Description	Category
rs3918290	DPYD *2A	Most critical pharmacogenomic variant causing complete loss of DPD enzyme fun...	Pharmacogenomics	Fluoropyrimidine Toxicity	Established
rs55886062	DPYD *13	No-function DPYD star allele (I560S) causing severe DPD deficiency; one of fo...	Pharmacogenomics	Fluoropyrimidine Toxicity	Established
rs56038477	DPYD HapB3 tag (c.1236G>A, E412E)	Synonymous exon-11 tag SNP for the DPYD HapB3 haplotype; benign on its own bu...	Pharmacogenomics	Fluoropyrimidine Toxicity	Established
rs67376798	DPYD D949V	Decreased-function variant reducing DPD enzyme activity ~30%, requiring 50% f...	Pharmacogenomics	Fluoropyrimidine Toxicity	Established
rs75017182	DPYD HapB3 (c.1129-5923C>G)	Deep intronic splice-site variant that is the functional driver of the DPYD H...	Pharmacogenomics	Fluoropyrimidine Toxicity	Established