Tag

Gut Health

19 genetic variants with this tag.

RSID	Gene	Description	Category
rs10063949	SLC23A1 SLC23A1 variant	Intronic variant in the intestinal and renal vitamin C transporter gene (SVCT...	Vitamins & Nutrient Absorption	Gut Health	Moderate
rs104895444	NOD2	Rare NOD2 missense variant (Val793Met) identified in IBD deep-resequencing; c...	IBD & Mucosal Immunity	Gut Health	Moderate
rs1050152	SLC22A4 OCTN1 L503F	Missense variant in SLC22A4 encoding the organic cation/ergothioneine transpo...	Allergy & Atopic Disease	Gut Health	Strong
rs121434290	SLC39A4 SLC39A4 p.Asn106Lys	Pathogenic missense variant in the ZIP4 intestinal zinc transporter; homozygo...	Iron & Mineral Transport	Gut Health	Established
rs1049742	AOC1	Missense variant in the diamine oxidase enzyme that contributes to reduced hi...	Methylation & Detox	Gut Health	Moderate
rs11362	DEFB1 G-20A	5' UTR variant in the beta-defensin 1 gene that reduces antimicrobial peptide...	IBD & Mucosal Immunity	Gut Health	Moderate
rs1799724	TNF -857C>T	TNF promoter variant that disrupts an OCT-1 binding site, altering TNF-alpha ...	TNF, NF-kB & Inflammatory Cytokines	Gut Health	Moderate
rs145946881	MCM6 -14010G>C	African lactase persistence variant — MCM6 enhancer SNP that controls LCT exp...	Vitamins & Nutrient Absorption	Gut Health	Strong
rs3024491	IL10 Intronic variant	Intronic IL10 variant that reduces anti-inflammatory cytokine production, ind...	Interferon Signaling & Systemic Autoimmune	Gut Health	Moderate
rs3024505	IL10 3' downstream variant	Downstream IL10 enhancer variant that disrupts a STAT3 binding site, reducing...	Interferon Signaling & Systemic Autoimmune	Gut Health	Strong
rs2976388	PSCA PSCA bladder urothelial variant	Intronic PSCA variant that tags a regulatory region active in bladder urothel...	Innate Immunity & Infection Defense	Gut Health	Strong
rs2631367	SLC22A5 OCTN2 -207C>G	Promoter variant in SLC22A5 (OCTN2) that reduces carnitine transporter expres...	IBD & Mucosal Immunity	Gut Health	Strong
rs4562997	SMAD3	Second intronic enhancer variant in SMAD3 that modulates TGF-beta effector si...	IBD & Mucosal Immunity	Gut Health	Moderate
rs41380347	MCM6 G-13915T	East African lactase persistence allele — MCM6 enhancer SNP that independentl...	Vitamins & Nutrient Absorption	Gut Health	Strong
rs17293632	SMAD3	Intronic regulatory variant in SMAD3 that alters TGF-beta effector signaling ...	Allergy & Atopic Disease	Gut Health	Strong
rs6908425	CDKAL1	Intronic variant in CDKAL1, a tRNA methylthiotransferase gene; the C allele i...	IBD & Mucosal Immunity	Gut Health	Strong
rs6974491	ELMO1	Intronic ELMO1 variant acting as an eQTL that modulates engulfment and cell m...	IBD & Mucosal Immunity	Gut Health	Moderate
rs2291725	GIP Ser103Gly	Missense variant in the GIP incretin hormone that changes its bioactivity and...	Hormones & Sleep	Gut Health	Moderate
rs7061710	FMO3	Intronic FMO3 variant associated with reduced hepatic oxidation of garlic-der...	Vitamins & Nutrient Absorption	Gut Health	Moderate