Tag
Immunosuppressants
9 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1045642 | ABCB1 C3435T | Synonymous variant in P-glycoprotein affecting drug efflux pump expression an... | Pharmacogenomics | Moderate | |
| rs1142345 | TPMT *3C | No-function variant causing deficient thiopurine methylation; most common TPM... | Pharmacogenomics | Established | |
| rs116855232 | NUDT15 Arg139Cys | Nucleotide diphosphatase that inactivates toxic thiopurine metabolites; reduc... | Pharmacogenomics | Established | |
| rs1800460 | TPMT *3B | Decreased-function variant causing reduced thiopurine methylation; pairs with... | Pharmacogenomics | Established | |
| rs2246709 | CYP3A4 | Intronic CYP3A4 variant associated with altered drug clearance, affecting met... | Pharmacogenomics | Moderate | |
| rs35599367 | CYP3A4 *22 | Intronic splice variant causing ~50% reduced CYP3A4 mRNA expression, affectin... | Pharmacogenomics | Established | |
| rs3745274 | CYP2B6 516G>T | Decreased-function variant affecting metabolism of efavirenz, methadone, bupr... | Pharmacogenomics | Established | |
| rs55785340 | CYP3A4 *2 | Missense variant reducing CYP3A4-mediated nifedipine clearance, causing eleva... | Pharmacogenomics | Moderate | |
| rs776746 | CYP3A5 *3 | Splice site variant creating a non-functional CYP3A5 enzyme, dramatically aff... | Pharmacogenomics | Established |