Tag

Immunosuppressants

14 genetic variants with this tag.

RSID	Gene	Description	Category
rs1045642	ABCB1 C3435T	Synonymous variant in P-glycoprotein affecting drug efflux pump expression an...	Pharmacogenomics	Immunosuppressants	Moderate
rs1142345	TPMT *3C	No-function variant causing deficient thiopurine methylation; most common TPM...	Pharmacogenomics	Immunosuppressants	Established
rs116855232	NUDT15 Arg139Cys	Nucleotide diphosphatase that inactivates toxic thiopurine metabolites; reduc...	Pharmacogenomics	Immunosuppressants	Established
rs12721629	CYP3A4 *16B	Missense variant causing substrate-dependent reduced CYP3A4 activity, most pr...	Pharmacogenomics	Immunosuppressants	Moderate
rs1800460	TPMT *3B	Decreased-function variant causing reduced thiopurine methylation; pairs with...	Pharmacogenomics	Immunosuppressants	Established
rs1800462	TPMT *2	The original TPMT deficiency allele — a no-function star allele causing ~100-...	Pharmacogenomics	Immunosuppressants	Established
rs2242480	CYP3A4 *1G	Intronic variant in CYP3A4 intron 10 that upregulates a suppressive lncRNA, r...	Pharmacogenomics	Immunosuppressants	Strong
rs2246709	CYP3A4	Intronic CYP3A4 variant associated with altered drug clearance, affecting met...	Pharmacogenomics	Immunosuppressants	Moderate
rs28371759	CYP3A4 *18 (L293R)	Rare missense variant causing a Leu293Arg substitution in CYP3A4, associated ...	Pharmacogenomics	Immunosuppressants	Moderate
rs35599367	CYP3A4 *22	Intronic splice variant causing ~50% reduced CYP3A4 mRNA expression, affectin...	Pharmacogenomics	Immunosuppressants	Established
rs3745274	CYP2B6 516G>T	Decreased-function variant affecting metabolism of efavirenz, methadone, bupr...	Pharmacogenomics	Immunosuppressants	Established
rs4646438	CYP3A4 *6 (17776insA / frameshift)	Frameshift insertion in CYP3A4 exon 9 that produces a truncated, non-function...	Pharmacogenomics	Immunosuppressants	Strong
rs55785340	CYP3A4 *2	Missense variant reducing CYP3A4-mediated nifedipine clearance, causing eleva...	Pharmacogenomics	Immunosuppressants	Moderate
rs776746	CYP3A5 *3	Splice site variant creating a non-functional CYP3A5 enzyme, dramatically aff...	Pharmacogenomics	Immunosuppressants	Established