Tag

Immunosuppressants

6 genetic variants with this tag.

RSID	Gene	Description	Category
rs776746	CYP3A5 *3	Splice site variant creating a non-functional CYP3A5 enzyme, dramatically aff...	Pharmacogenomics	Drug Metabolism Immunosuppressants Pharmacogenomics	Established
rs3745274	CYP2B6 516G>T	Decreased-function variant affecting metabolism of efavirenz, methadone, bupr...	Pharmacogenomics	Drug Metabolism Antidepressants Pain Medication	Established
rs1142345	TPMT *3C	No-function variant causing deficient thiopurine methylation; most common TPM...	Pharmacogenomics	Drug Metabolism Immunosuppressants Blood Thinners	Established
rs1045642	ABCB1 C3435T	Synonymous variant in P-glycoprotein affecting drug efflux pump expression an...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Immunosuppressants	Moderate
rs116855232	NUDT15 Arg139Cys	Nucleotide diphosphatase that inactivates toxic thiopurine metabolites; reduc...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Chemotherapy	Established
rs35599367	CYP3A4 *22	Intronic splice variant causing ~50% reduced CYP3A4 mRNA expression, affectin...	Pharmacogenomics	Drug Metabolism Statins Immunosuppressants	Established