Tag

Pain Medication

26 genetic variants with this tag.

RSID	Gene	Description	Category
rs10403955	CYP2B6	Intronic CYP2B6 haplotype-tagging variant associated with altered plasma conc...	Pharmacogenomics	Pain Medication	Moderate
rs1057910	CYP2C9 *3	No-function CYP2C9 variant with major warfarin implications	Pharmacogenomics	Pain Medication	Established
rs1058164	CYP2D6	Synonymous CYP2D6 variant that promotes exon 3 skipping, reducing functional ...	Pharmacogenomics	Pain Medication	Moderate
rs1065852	CYP2D6 *10	Decreased function CYP2D6 variant common in Asian populations	Pharmacogenomics	Pain Medication	Established
rs1080985	CYP2D6 *2A promoter	CYP2D6 promoter variant (-1584C>G) that reduces enzyme expression; the C alle...	Pharmacogenomics	Pain Medication	Strong
rs1113129	CYP2C8	Intronic tagging SNP for CYP2C8 haplotype C, a low-activity haplotype associa...	Pharmacogenomics	Pain Medication	Moderate
rs16947	CYP2D6 *2	Common CYP2D6 variant defining the *2 allele; previously considered normal-fu...	Pharmacogenomics	Pain Medication	Strong
rs17002852	CYP2D6	Synonymous CYP2D6 variant that causes allele dropout in standard CYP2D6*3 gen...	Pharmacogenomics	Pain Medication	Moderate
rs1799853	CYP2C9 *2	Decreased function variant affecting warfarin, phenytoin, and NSAIDs	Pharmacogenomics	Pain Medication	Established
rs1799971	OPRM1 A118G	Mu-opioid receptor variant affecting opioid response, pain sensitivity, and p...	Pharmacogenomics	Pain Medication	Strong
rs1934963	CYP2C9	Deep intronic CYP2C9 variant associated with altered drug response to sulfony...	Pharmacogenomics	Pain Medication	Emerging
rs1934967	CYP2C9	Intronic CYP2C9 haplotype tag associated with altered warfarin sensitivity an...	Pharmacogenomics	Pain Medication	Moderate
rs2246709	CYP3A4	Intronic CYP3A4 variant associated with altered drug clearance, affecting met...	Pharmacogenomics	Pain Medication	Moderate
rs28371706	CYP2D6 *17	Decreased-function CYP2D6 allele common in African populations, reducing meta...	Pharmacogenomics	Pain Medication	Established
rs28371725	CYP2D6 *41	Intronic splice variant causing decreased CYP2D6 enzyme activity through aber...	Pharmacogenomics	Pain Medication	Established
rs28371733	CYP2D6	Rare CYP2D6 stop-gain variant (Glu418Ter) that eliminates enzyme activity, ca...	Pharmacogenomics	Pain Medication	Established
rs28695233	CYP2D6	Deep intronic CYP2D6 variant in intron 2 that serves as a haplotype tag in sp...	Pharmacogenomics	Pain Medication	Emerging
rs373489637	CYP2B6 V183G	Near-complete loss-of-function CYP2B6 variant causing severely impaired metab...	Pharmacogenomics	Pain Medication	Moderate
rs3745274	CYP2B6 516G>T	Decreased-function variant affecting metabolism of efavirenz, methadone, bupr...	Pharmacogenomics	Pain Medication	Established
rs3892097	CYP2D6 *4	CYP2D6 *4 splice-defect null allele — the most common loss-of-function CYP2D6...	Pharmacogenomics	Pain Medication	Established
rs5030655	CYP2D6 *6	Frameshift deletion causing no enzyme function, defining poor metabolizer sta...	Pharmacogenomics	Pain Medication	Established
rs58440431	CYP2D6	Intronic CYP2D6 variant tagging East Asian *10-lineage suballeles; the C alle...	Pharmacogenomics	Pain Medication	Strong
rs640561	LRRIQ3	Intergenic variant near LRRIQ3 associated with problematic opioid prescriptio...	Pharmacogenomics	Pain Medication	Emerging
rs67807361	CYP2C9 p.Leu19Ile	Rare CYP2C9 N-terminal missense variant of uncertain functional significance ...	Pharmacogenomics	Pain Medication	Emerging
rs71328650	CYP2D6	Intronic CYP2D6 haplotype tag variant (rs28371702 canonical form) associated ...	Pharmacogenomics	Pain Medication	Emerging
rs72549354	CYP2D6 *20	Frameshift insertion creating a null CYP2D6 allele; carriers cannot metaboliz...	Pharmacogenomics	Pain Medication	Established