Tag

Pain Sensitivity

24 genetic variants with this tag.

RSID	Gene	Description	Category
rs1003194	CALCA/CALCB	Intergenic regulatory variant ~26 kb downstream of CALCB (calcitonin gene-rel...	Neurology & Cognition	Pain Sensitivity	Strong
rs10166942	TRPM8	Upstream regulatory variant of the cold-sensing TRPM8 channel that modulates ...	Neurology & Cognition	Pain Sensitivity	Strong
rs10405121	CACNA1A	Common intronic variant in CACNA1A — the P/Q-type calcium channel gene mutate...	Neurology & Cognition	Pain Sensitivity	Strong
rs10456100	KCNK5	Intronic variant near KCNK5 that reduces TASK2 potassium channel expression a...	Neurology & Cognition	Pain Sensitivity	Strong
rs1800629	TNF -308 G>A	Promoter variant increasing TNF-alpha production approximately 2-fold, associ...	TNF, NF-kB & Inflammatory Cytokines	Pain Sensitivity	Strong
rs142885915	NPSR1 NPSR1 Endometriosis Risk Variant	An intronic insertion/deletion variant in the neuropeptide S receptor 1 gene ...	Endometriosis & Uterine Health	Pain Sensitivity	Moderate
rs16147	NPY C-399T	Promoter variant in neuropeptide Y that modulates NPY expression under stress...	Mood & Behavior	Pain Sensitivity	Moderate
rs1805007	MC1R R151C	Strongest "R" allele in the melanocortin-1 receptor, shifting pigment from ph...	Skin & Eyes	Pain Sensitivity	Established
rs12598836	HMOX2	Intronic variant near heme oxygenase 2 (HMOX2) associated with migraine-with-...	Neurology & Cognition	Pain Sensitivity	Moderate
rs1718119	P2RX7 Ala348Thr	Gain-of-function variant in the P2X7 receptor that increases ATP-gated pore f...	Neurology & Cognition	Pain Sensitivity	Moderate
rs689466	PTGS2 A-1195G	Promoter variant in the PTGS2/COX-2 gene that reduces baseline COX-2 expressi...	IBD & Mucosal Immunity	Pain Sensitivity	Moderate
rs2078371	TSPAN2	Regulatory variant in the TSPAN2/NGF locus on chromosome 1p13; the C allele i...	Neurology & Cognition	Pain Sensitivity	Strong
rs208294	P2RX7 His155Tyr	Gain-of-function missense variant in the P2X7 ATP-gated receptor that increas...	Neurology & Cognition	Pain Sensitivity	Moderate
rs2274319	MEF2D	Intronic variant in MEF2D encoding a key neuronal transcription factor that r...	Neurology & Cognition	Pain Sensitivity	Strong
rs306960	PTK2	Intronic variant in PTK2 (focal adhesion kinase) linked to restless legs synd...	Neurology & Cognition	Pain Sensitivity	Strong
rs3791033	KDM4A	Intronic variant in KDM4A histone demethylase associated with problematic opi...	Pharmacogenomics	Pain Sensitivity	Moderate
rs3751143	P2RX7 Glu496Ala	Loss-of-function variant in the P2X7 receptor that reduces inflammatory respo...	Neurology & Cognition	Pain Sensitivity	Strong
rs61759167	PRDM16	Intronic PRDM16 variant reaching genome-wide significance in the first motion...	Neurology & Cognition	Pain Sensitivity	Strong
rs58194899	EIPR1	Intronic variant in EIPR1 (endosomal trafficking protein) associated with pai...	Pharmacogenomics	Pain Sensitivity	Emerging
rs6746030	SCN9A R1150W	Common variant in the Nav1.7 sodium channel affecting pain sensitivity and pa...	Neurology & Cognition	Pain Sensitivity	Strong
rs6777055	CACNA2D3	Intronic variant affecting thermal pain sensitivity and central pain signal t...	Neurology & Cognition	Pain Sensitivity	Moderate
rs7958311	P2RX7 Arg270His	P2RX7 variant with a unique dual mechanism — gain-of-function in channel open...	Neurology & Cognition	Pain Sensitivity	Moderate
rs8007267	GCH1	Promoter variant affecting GTP cyclohydrolase 1 expression and pain sensitivi...	Neurology & Cognition	Pain Sensitivity	Strong
rs8065080	TRPV1 Ile585Val	Capsaicin receptor variant affecting heat and pain sensitivity	Neurology & Cognition	Pain Sensitivity	Strong