Tag

Pain Sensitivity

11 genetic variants with this tag.

RSID	Gene	Description	Category
rs1805007	MC1R R151C	Strongest "R" allele in the melanocortin-1 receptor, shifting pigment from ph...	Skin & Eyes	Pain Sensitivity Skin Health Anesthesia	Established
rs6746030	SCN9A R1150W	Common variant in the Nav1.7 sodium channel affecting pain sensitivity and pa...	Brain & Mental Health	Pain Sensitivity Neurotransmitters Anesthesia	Strong
rs8065080	TRPV1 Ile585Val	Capsaicin receptor variant affecting heat and pain sensitivity	Brain & Mental Health	Pain Sensitivity Neurotransmitters Cardiovascular	Strong
rs8007267	GCH1	Promoter variant affecting GTP cyclohydrolase 1 expression and pain sensitivi...	Brain & Mental Health	Pain Sensitivity Nitric Oxide Neurotransmitters	Strong
rs6777055	CACNA2D3	Intronic variant affecting thermal pain sensitivity and central pain signal t...	Brain & Mental Health	Pain Sensitivity Neurotransmitters Sensory Processing	Moderate
rs3751143	P2RX7 Glu496Ala	Loss-of-function variant in the P2X7 receptor that reduces inflammatory respo...	Brain & Mental Health	Pain Sensitivity Inflammation Immune Function	Strong
rs10166942	TRPM8	Upstream regulatory variant of the cold-sensing TRPM8 channel that modulates ...	Brain & Mental Health	Brain Health Pain Sensitivity Thermogenesis	Strong
rs16147	NPY C-399T	Promoter variant in neuropeptide Y that modulates NPY expression under stress...	Brain & Mental Health	Stress Response Appetite Obesity	Moderate
rs208294	P2RX7 His155Tyr	Gain-of-function missense variant in the P2X7 ATP-gated receptor that increas...	Brain & Mental Health	Neuroinflammation Pain Sensitivity Chronic Pain	Moderate
rs1718119	P2RX7 Ala348Thr	Gain-of-function variant in the P2X7 receptor that increases ATP-gated pore f...	Brain & Mental Health	Neuroinflammation Pain Sensitivity Inflammation	Moderate
rs7958311	P2RX7 Arg270His	P2RX7 variant with a unique dual mechanism — gain-of-function in channel open...	Brain & Mental Health	Pain Sensitivity Neuroinflammation Inflammation	Moderate