Tag
Pancreatic Beta Cell
20 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10010131 | WFS1 WFS1 Intron 4 T2D Risk Variant | Intronic variant in WFS1 (wolframin) on chromosome 4q22, one of the earliest ... | Blood Sugar & Diabetes | Strong | |
| rs10515237 | PCSK1 PCSK1 A/G (rs10515237) | Intronic variant in PCSK1 that tags the Q665E-S690T functional haplotype | Appetite & Obesity | Moderate | |
| rs10278336 | YKT6 GCK-Region Intronic Variant | Intronic variant in YKT6 immediately downstream of GCK; the A allele is a GWA... | Blood Sugar & Diabetes | Moderate | |
| rs11052552 | CLECL1 | Intronic variant in CLECL1, a dendritic-cell costimulatory C-type lectin, ass... | Appetite & Obesity | Moderate | |
| rs10811661 | CDKN2B | Regulatory variant upstream of CDKN2A/CDKN2B at the 9p21 locus; the T risk al... | Blood Sugar & Diabetes | Strong | |
| rs10885122 | ADRA2A ADRA2A Beta-Cell cAMP Variant | Intergenic variant near ADRA2A | Blood Sugar & Diabetes | Moderate | |
| rs1111875 | HHEX HHEX/IDE locus T2D risk variant | Primary tag SNP at the HHEX/IDE locus on chromosome 10q23, one of the earlies... | Blood Sugar & Diabetes | Established | |
| rs563694 | ABCB11 G6PC2/ABCB11 fasting glucose locus | Intronic variant in ABCB11 in strong linkage disequilibrium with G6PC2 regula... | Liver Fat | Strong | |
| rs1169288 | HNF1A HNF1A Ile27Leu | Common coding variant in the HNF1A transcription factor dimerization domain t... | Blood Sugar & Diabetes | Strong | |
| rs1884614 | HNF4A HNF4A P2 Promoter rs1884614 | Intronic variant tagging the HNF4A P2 promoter risk haplotype; the T allele i... | Hormones & Sleep | Moderate | |
| rs6232 | PCSK1 PCSK1 N221D (Asn221Asp) | Missense variant in PCSK1 encoding an Asn221Asp substitution near the Ca-1 ca... | Appetite & Obesity | Strong | |
| rs2144908 | HNF4A HNF4A P2 Block rs2144908 | Intronic HNF4A P2 promoter haplotype tag variant; carriers have modestly impa... | Hormones & Sleep | Moderate | |
| rs1801278 | IRS1 Gly972Arg (G972R) | Missense variant in insulin receptor substrate 1 that impairs tyrosine phosph... | Blood Sugar & Diabetes | Strong | |
| rs2268574 | GCK c.679+38T>G | Intronic GCK variant 38 bp downstream of exon 7; the A allele (GRCh38 referen... | Blood Sugar & Diabetes | Emerging | |
| rs391300 | SRR SRR rs391300 | Intronic variant in serine racemase that alters D-serine production in pancre... | Blood Sugar & Diabetes | Moderate | |
| rs4607517 | GCK GCK fasting glucose GWAS variant | Common variant near glucokinase that raises fasting glucose by impairing the ... | Blood Sugar & Diabetes | Strong | |
| rs4807015 | PTPRS PTPRS T2D risk variant | Intronic PTPRS variant that tags elevated type 2 diabetes risk in both sexes ... | Blood Sugar & Diabetes | Moderate | |
| rs5210 | KCNJ11 KCNJ11 Kir6.2 Co-Variant | A regulatory 3' UTR variant in KCNJ11 that modulates KATP channel expression ... | Blood Sugar & Diabetes | Moderate | |
| rs564398 | CDKN2B-AS1 | Secondary T2D risk variant at the 9p21 CDKN2A/B locus within ANRIL (CDKN2B-AS... | Blood Sugar & Diabetes | Moderate | |
| rs7202877 | CTRB1 | Intergenic variant near CTRB1/CTRB2 that regulates chymotrypsinogen expressio... | Blood Sugar & Diabetes | Strong |