Tag

Sleep

69 genetic variants with this tag.

RSID	Gene	Description	Category
rs10462020	PER3 V647G	Missense variant in circadian clock gene PER3 associated with morning chronot...	Hormones & Sleep	Sleep	Moderate
rs10038916	GRIA1	Intronic variant in the AMPA glutamate receptor gene GRIA1 associated with re...	Neurology & Cognition	Sleep	Strong
rs1064608	MTCH2 Pro290Ala	Missense variant in MTCH2 that reduces mitochondrial metabolic efficiency, in...	Hormones & Sleep	Sleep	Moderate
rs10766383	NUCB2	Intronic NUCB2 variant associated with type 2 diabetes risk in females and or...	Hormones & Sleep	Sleep	Moderate
rs10830963	MTNR1B Intron C>G	Melatonin receptor variant that extends nighttime melatonin signaling in panc...	Hormones & Sleep	Sleep	Established
rs10947690	MDGA1 Leu61Pro	Missense variant in the inhibitory synapse regulator MDGA1 that impairs neuro...	Hormones & Sleep	Sleep	Strong
rs11071559	RORA	Intronic variant in the circadian clock regulator RORA; the T allele is prote...	Allergy & Atopic Disease	Sleep	Moderate
rs1144566	RGS16 RGS16 H137R	Missense variant in RGS16 that substitutes histidine for arginine at position...	Hormones & Sleep	Sleep	Moderate
rs1154155	TRA	T-cell receptor alpha locus variant associated with narcolepsy susceptibility...	Hormones & Sleep	Sleep	Strong
rs10839553	CCKBR	Intronic variant near the cholecystokinin B receptor gene associated with res...	Neurology & Cognition	Sleep	Strong
rs11545787	RASD1 RASD1 photic entrainment variant	3' UTR variant in RASD1 (Dexras1), a GTPase that gates light signals to the c...	Hormones & Sleep	Sleep	Strong
rs10895816	GRIA4	Intronic variant in the AMPA glutamate receptor gene GRIA4 associated with re...	Neurology & Cognition	Sleep	Strong
rs11605924	CRY2 Intron Variant	Circadian clock gene variant affecting fasting glucose, hepatic lipid metabol...	Hormones & Sleep	Sleep	Strong
rs12736689	RGS16	Intronic/regulatory variant near RGS16 that is the strongest single-locus mor...	Hormones & Sleep	Sleep	Strong
rs1330	NUCB2	Intronic NUCB2 variant associated with obesity risk in males, type 2 diabetes...	Hormones & Sleep	Sleep	Moderate
rs117896735	INPP5F	Intronic variant in the INPP5F/BAG3 locus associated with increased risk of R...	Neurology & Cognition	Sleep	Strong
rs1369481	NPAS2	Intronic variant in the brain-specific circadian transcription factor NPAS2; ...	Hormones & Sleep	Sleep	Emerging
rs139315125	PER3 H417R	Rare PER3 missense variant that co-occurs on the FASPS3 haplotype with Pro415...	Hormones & Sleep	Sleep	Strong
rs57875989	PER3 PER3 VNTR (4/5 repeat)	Coding VNTR in exon 18 of the circadian clock gene PER3; 4-repeat vs 5-repeat...	Arrhythmia & Heart Rhythm	Sleep	Moderate
rs150812083	PER3 PER3 Pro415Ala (FASPS3)	Rare PER3 missense variant that destabilizes the circadian clock protein, sho...	Hormones & Sleep	Sleep	Strong
rs1554483	CLOCK	Intronic CLOCK variant whose G allele, in a haplotype with rs4864548 A, confe...	Hormones & Sleep	Sleep	Moderate
rs17493811	AGER	Tag SNP in the AGER 3′ downstream region associated with increased type 1 dia...	Hormones & Sleep	Sleep	Moderate
rs17679445	PNPO Arg116Gln	Missense variant in pyridoxamine 5'-phosphate oxidase that reduces the enzyme...	Hormones & Sleep	Sleep	Moderate
rs2271933	HCRTR1 Ile408Val	Missense variant in the orexin/hypocretin receptor 1 that alters G-protein si...	Mood & Behavior	Sleep	Moderate
rs12693542	SLC40A1	Regulatory variant upstream of ferroportin (the sole cellular iron exporter) ...	Neurology & Cognition	Sleep	Strong
rs12752133	GBA	Intronic GBA variant associated with REM sleep behavior disorder via lysosoma...	Neurology & Cognition	Sleep	Strong
rs1800624	AGER -374T/A	Promoter variant in the AGER gene that increases RAGE transcription approxima...	Hormones & Sleep	Sleep	Moderate
rs1801260	CLOCK 3111T>C (3'UTR)	Core circadian clock transcription factor variant affecting mRNA stability, a...	Hormones & Sleep	Sleep	Moderate
rs184039278	CRY1 CRY1Δ11	Splice-site variant in the circadian clock gene CRY1 that causes exon 11 skip...	Hormones & Sleep	Sleep	Strong
rs1991517	TSHR Asp727Glu	Affects TSH receptor sensitivity and thyroid hormone regulation; influences T...	Hormones & Sleep	Sleep	Strong
rs1562444	MTNR1B MTNR1B 3'UTR Melatonin Signaling Variant	Regulatory 3'UTR variant in the melatonin receptor 1B gene that affects MTNR1...	Blood Sugar & Diabetes	Sleep	Moderate
rs2050122	HTR6	Regulatory variant near the HTR6 serotonin 6 receptor gene associated with ch...	Hormones & Sleep	Sleep	Moderate
rs2066853	AHR Arg554Lys	Aryl hydrocarbon receptor variant in the transactivation domain that alters A...	Hormones & Sleep	Sleep	Moderate
rs2070600	AGER Gly82Ser	Missense variant in the AGER pattern-recognition receptor that reduces solubl...	Hormones & Sleep	Sleep	Strong
rs228697	PER3 Pro864Ala	Core clock gene variant that shifts circadian period length and influences mo...	Hormones & Sleep	Sleep	Moderate
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Sleep	Strong
rs2291725	GIP Ser103Gly	Missense variant in the GIP incretin hormone that changes its bioactivity and...	Hormones & Sleep	Sleep	Moderate
rs2304672	PER2 5'UTR C111G	Regulatory variant in a core clock gene that influences circadian timing, sle...	Hormones & Sleep	Sleep	Moderate
rs2325751	PNPO	Regulatory variant 2 kb upstream of PNPO that may alter expression of the vit...	Hormones & Sleep	Sleep	Emerging
rs2675703	OPN4	Missense variant (Pro10Leu) in melanopsin, the photopigment driving circadian...	Hormones & Sleep	Sleep	Emerging
rs28362944	SERPING1	5' UTR variant in C1-inhibitor gene that promotes partial exon 2 skipping, re...	Hormones & Sleep	Sleep	Moderate
rs324981	NPSR1 Asn107Ile	Gain-of-function missense variant in the neuropeptide S receptor that increas...	Hormones & Sleep	Sleep	Moderate
rs2230912	P2RX7 Gln460Arg	Missense variant in the C-terminal domain of the P2X7 receptor that disrupts ...	Neurology & Cognition	Sleep	Moderate
rs34714364	APH1A APH1A gamma-secretase variant	Synonymous variant in CA14 near APH1A; T allele is associated with morning ch...	Hormones & Sleep	Sleep	Moderate
rs34903499	VIP	Synonymous coding variant in the VIP gene (Asn133Asn); the T allele may alter...	Hormones & Sleep	Sleep	Emerging
rs35333999	PER2 V903I	Missense variant in core circadian clock gene PER2 that lengthens intrinsic c...	Hormones & Sleep	Sleep	Strong
rs35833281	HCRTR2	Intronic variant in the orexin/hypocretin receptor 2 gene that tags the HCRTR...	Hormones & Sleep	Sleep	Strong
rs3754048	APH1A -980C/G	Regulatory variant 2 kb upstream of APH1A where the C allele (paper's G, codi...	Hormones & Sleep	Sleep	Moderate
rs3816183	HAAO Ile37Val	Missense variant in the kynurenine pathway enzyme HAAO that shifts tryptophan...	Hormones & Sleep	Sleep	Moderate
rs3923809	BTBD9	Second independent intronic BTBD9 variant associated with restless legs syndr...	Hormones & Sleep	Sleep	Strong
rs2653349	HCRTR2 Ile308Val	Missense variant at position 308 of the orexin receptor 2 protein; the minor ...	Neurology & Cognition	Sleep	Strong
rs4307059	CDH9/CDH10	Intergenic variant at 5p14.1 between neuronal cell-adhesion genes CDH9 and CD...	Hormones & Sleep	Sleep	Strong
rs4410790	AHR	Regulatory variant 54 kb upstream of the aryl hydrocarbon receptor gene; the ...	Hormones & Sleep	Sleep	Strong
rs306960	PTK2	Intronic variant in PTK2 (focal adhesion kinase) linked to restless legs synd...	Neurology & Cognition	Sleep	Strong
rs4446909	ASMT Promoter A>G	Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression...	Hormones & Sleep	Sleep	Moderate
rs3129934	HLA-DRB5 DR15 haplotype tag	Tag SNP for HLA-DRB5*01:01 on the DR15 susceptibility haplotype, physically n...	Neurology & Cognition	Sleep	Strong
rs4746	GLO1 Glu111Ala	Missense variant in glyoxalase 1 reducing enzyme activity, allowing methylgly...	Hormones & Sleep	Sleep	Moderate
rs4753426	MTNR1B	Promoter variant in the melatonin receptor 1B gene that alters MTNR1B express...	Hormones & Sleep	Sleep	Moderate
rs4926	SERPING1 Val480Met	Missense variant in C1-inhibitor gene associated with insomnia risk through n...	Hormones & Sleep	Sleep	Moderate
rs516134	RGS16 RGS16 chronotype variant	Regulatory variant ~20 kb downstream of RGS16 that influences circadian chron...	Hormones & Sleep	Sleep	Strong
rs55694368	PER2 PER2 regulatory variant	Upstream regulatory signal near the core circadian clock gene PER2 that shift...	Hormones & Sleep	Sleep	Strong
rs5751876	ADORA2A 1976T>C	Adenosine A2A receptor variant that determines individual sensitivity to caff...	Hormones & Sleep	Sleep	Strong
rs3756059	SNCA	Intronic SNCA variant at the 5′ locus associated with REM sleep behavior diso...	Neurology & Cognition	Sleep	Strong
rs757081	NUCB2 Gln338Glu (Q338E)	Missense variant in nucleobindin-2, the precursor protein cleaved to produce ...	Hormones & Sleep	Sleep	Moderate
rs9394502	BTBD9 BTBD9 insomnia/RLS variant	Intronic variant in the canonical restless legs syndrome gene BTBD9, associat...	Hormones & Sleep	Sleep	Strong
rs9479402	VIP VIP chronotype variant	Intergenic variant ~54 kb downstream of the VIP gene; the C allele reduces VI...	Hormones & Sleep	Sleep	Strong
rs9565309	FBXL3 FBXL3 circadian variant	Regulatory variant near FBXL3 that modulates circadian period length; the C a...	Hormones & Sleep	Sleep	Strong
rs76763715	GBA N409S	GBA missense variant (p.Asn409Ser, formerly N370S) — the most common GBA path...	Neurology & Cognition	Sleep	Established
rs7697073	SCARB2	Intronic SCARB2 variant associated with REM sleep behavior disorder risk via ...	Neurology & Cognition	Sleep	Moderate