Tag

Sleep

15 genetic variants with this tag.

RSID	Gene	Description	Category
rs1801260	CLOCK 3111T>C (3'UTR)	Core circadian clock transcription factor variant affecting mRNA stability, a...	Hormones & Sleep	Sleep Circadian Chronotype	Moderate
rs228697	PER3 Pro864Ala	Core clock gene variant that shifts circadian period length and influences mo...	Hormones & Sleep	Sleep Circadian Chronotype	Moderate
rs2304672	PER2 5'UTR C111G	Regulatory variant in a core clock gene that influences circadian timing, sle...	Hormones & Sleep	Sleep Circadian Chronotype	Moderate
rs10830963	MTNR1B Intron C>G	Melatonin receptor variant that extends nighttime melatonin signaling in panc...	Hormones & Sleep	Sleep Melatonin Circadian	Established
rs4446909	ASMT Promoter A>G	Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression...	Hormones & Sleep	Sleep Melatonin Circadian	Moderate
rs5751876	ADORA2A 1976T>C	Adenosine A2A receptor variant that determines individual sensitivity to caff...	Hormones & Sleep	Sleep Caffeine Anxiety	Strong
rs2066853	AHR Arg554Lys	Aryl hydrocarbon receptor variant in the transactivation domain that alters A...	Hormones & Sleep	Sleep Circadian Caffeine	Moderate
rs324981	NPSR1 Asn107Ile	Gain-of-function missense variant in the neuropeptide S receptor that increas...	Hormones & Sleep	Sleep Arousal Anxiety	Moderate
rs1991517	TSHR Asp727Glu	Affects TSH receptor sensitivity and thyroid hormone regulation; influences T...	Hormones & Sleep	Hormones & Thyroid Thyroid Metabolism	Strong
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Circadian Sleep Chronotype	Strong
rs35333999	PER2 V903I	Missense variant in core circadian clock gene PER2 that lengthens intrinsic c...	Hormones & Sleep	Circadian Sleep Chronotype	Strong
rs11605924	CRY2 Intron Variant	Circadian clock gene variant affecting fasting glucose, hepatic lipid metabol...	Hormones & Sleep	Circadian Sleep Diabetes	Strong
rs10462020	PER3 V647G	Missense variant in circadian clock gene PER3 associated with morning chronot...	Hormones & Sleep	Circadian Sleep Chronotype	Moderate
rs2271933	HCRTR1 Ile408Val	Missense variant in the orexin/hypocretin receptor 1 that alters G-protein si...	Brain & Mental Health	Migraine Mood Anxiety	Moderate
rs2230912	P2RX7 Gln460Arg	Missense variant in the C-terminal domain of the P2X7 receptor that disrupts ...	Brain & Mental Health	Neuroinflammation Mental Health Mood	Moderate