Tag

Smoking

9 genetic variants with this tag.

RSID	Gene	Description	Category
rs1051730	CHRNA3 Tyr215Tyr	CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass...	Mood & Behavior	Smoking	Established
rs16969968	CHRNA5 Asp398Asn	Nicotinic receptor variant strongly associated with heavy smoking, nicotine d...	Mood & Behavior	Smoking	Established
rs2036527	CHRNA5/CHRNA3	Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr...	Mood & Behavior	Smoking	Strong
rs1801272	CYP2A6 *2 (L160H)	Loss-of-function CYP2A6 variant that abolishes nicotine metabolism, slowing c...	Pharmacogenomics	Smoking	Established
rs578776	CHRNA3 3' UTR	CHRNA3 3' UTR variant at 15q25.1 Locus 2 — mechanistically distinct from rs10...	Mood & Behavior	Smoking	Strong
rs588765	CHRNA5 5' UTR / Locus 3	Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres...	Mood & Behavior	Smoking	Strong
rs8034191	AGPHD1/CHRNA3 15q25.1 intergenic	Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re...	Mood & Behavior	Smoking	Strong
rs28399433	CYP2A6 *9 (TATA box)	Promoter variant that reduces CYP2A6 expression by ~50%, slowing nicotine met...	Pharmacogenomics	Smoking	Strong
rs28399444	CYP2A6 *7 (I471T)	CYP2A6*7 missense variant that nearly abolishes nicotine C-oxidase activity; ...	Pharmacogenomics	Smoking	Established