Tag

Triglycerides

75 genetic variants with this tag.

RSID	Gene	Description	Category
rs1044250	ANGPTL4 T266M	Protective missense variant that reduces LPL inhibition, lowering fasting tri...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs11072566	NRG4 NRG4 Variant	Common intronic variant at the NRG4 locus; NRG4 is a brown adipose tissue-enr...	Liver Fat	Triglycerides	Emerging
rs10846744	SCARB1	Intronic SCARB1 variant associated with altered HDL-receptor function, subcli...	Cholesterol & Lipoproteins	Triglycerides	Moderate
rs116843064	ANGPTL4 ANGPTL4 E40K	Missense variant that reduces ANGPTL4's inhibition of lipoprotein lipase, low...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs11857380	LIPC	Intronic LIPC variant tagging reduced hepatic lipase expression; G allele ass...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs1260326	GCKR P446L	Coding GCKR variant (Pro446Leu) that directly reduces GCKRP sensitivity to fr...	Liver Fat	Triglycerides	Strong
rs12678919	LPL	Intergenic variant 19 kb downstream of lipoprotein lipase (LPL) that tags a r...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs11568822	APOC1 APOC1 HCR-1 promoter variant	Promoter insertion variant in APOC1 that increases gene transcription by 50%,...	Cholesterol & Lipoproteins	Triglycerides	Moderate
rs13236689	CD36	Intronic CD36 variant that acts as a platelet eQTL, modulating CD36 surface e...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs13702	LPL	LPL 3'UTR variant disrupting a microRNA-410 binding site; the C allele abolis...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs1800588	LIPC -514C>T	Promoter variant that reduces hepatic lipase activity, raising HDL-C levels b...	Atherogenic Lipoproteins	Triglycerides	Strong
rs1800591	MTTP MTTP -493G/T	Promoter-region variant in MTTP that reduces hepatic MTTP transcription; the ...	Liver Fat	Triglycerides	Moderate
rs150090666	PDE3B PDE3B R783X	Loss-of-function variant in phosphodiesterase 3B — carriers have enhanced cAM...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs199673455	GPD1	Pathogenic missense variant in glycerol-3-phosphate dehydrogenase 1; homozygo...	Liver Fat	Triglycerides	Strong
rs1532085	LIPC	Intronic eQTL that reduces hepatic lipase expression, raising HDL-C levels wh...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs2131925	ANGPTL3 DOCK7/ANGPTL3 Locus Tag SNP	Intronic tag SNP in the DOCK7/ANGPTL3 region; the T allele is associated with...	Atherogenic Lipoproteins	Triglycerides	Strong
rs2642438	MTARC1 p.Ala165Thr (A165T)	Protective missense variant that reduces MTARC1 protein stability, cutting he...	Liver Fat	Triglycerides	Established
rs17321515	TRIB1	Near-gene variant 30–44 kb downstream of TRIB1; A allele raises triglycerides...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs4240624	PPP1R3B Near-gene variant	Intronic PPP1R3B variant that increases hepatic glycogen accumulation, elevat...	Liver Fat	Triglycerides	Strong
rs121918389	APOB Q1477X (apoB-32)	Nonsense mutation producing a severely truncated apolipoprotein B (apoB-32) t...	Cholesterol & Lipoproteins	Triglycerides	Strong
rs174537	FADS1	Regulatory variant in the FADS1 locus that controls delta-5 desaturase expres...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs4225	APOC3 APOC3 3'UTR c.*71G>T	3'UTR variant that creates a microRNA-4271 binding site; the T allele suppres...	Atherogenic Lipoproteins	Triglycerides	Moderate
rs4841132	PPP1R3B	Near-gene PPP1R3B variant used as primary tagging SNP in the Stender 2018 stu...	Liver Fat	Triglycerides	Strong
rs174541	FADS1 FADS1 C>G (delta-5 desaturase depth)	Intronic regulatory variant in FADS1 that reduces delta-5 desaturase expressi...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs121918391	APOB APOB Tyr1200Ter	Rare APOB stop-gain variant that truncates apolipoprotein B to ~27% of its fu...	Cholesterol & Lipoproteins	Triglycerides	Strong
rs174546	FADS1	3'UTR regulatory variant in FADS1 that disrupts a miR-149-5p binding site, re...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs17465637	MIA3	Intronic variant in MIA3/TANGO1 affecting collagen secretion and vascular smo...	Coronary Artery Disease & Atherosclerosis	Triglycerides	Strong
rs11868035	SREBF1	SREBF1 intronic/3'UTR variant affecting SREBP-1c expression, associated with ...	Fat Storage & Energy	Triglycerides	Moderate
rs12447924	CETP	Upstream promoter variant in CETP that tags the HDL-raising haplotype block —...	Cholesterol & Lipoproteins	Triglycerides	Moderate
rs5128	APOC3 3238C>G (SstI)	Regulates triglyceride metabolism through effects on APOC3 expression in the ...	Atherogenic Lipoproteins	Triglycerides	Strong
rs58542926	TM6SF2 E167K	Lipid transport variant that impairs VLDL secretion, creating a paradoxical t...	Liver Fat	Triglycerides	Strong
rs5174	LRP8 LRP8 R952Q	Missense variant in LRP8 (ApoER2) replacing arginine with glutamine at positi...	Atherogenic Lipoproteins	Triglycerides	Moderate
rs613084	CPT1A CPT1A carnitine shuttle variant	Intronic variant that influences CPT1A expression and fatty acid oxidation ca...	Liver Fat	Triglycerides	Moderate
rs1801175	G6PC1	Pathogenic missense variant in glucose-6-phosphatase catalytic subunit 1 caus...	Metabolic Enzymes & Rare Disorders	Triglycerides	Established
rs2229616	MC4R V103I	Missense variant in MC4R converting valine to isoleucine at position 103; the...	Appetite & Obesity	Triglycerides	Strong
rs641738	MBOAT7	Regulatory variant that reduces MBOAT7 expression in the liver, impairing pho...	Liver Fat	Triglycerides	Strong
rs174568	FADS2 FADS2 C>T (delta-6 desaturase)	Intronic regulatory variant in FADS2 encoding delta-6 desaturase, the rate-li...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs1800206	PPARA Leu162Val (L162V)	Missense variant in PPARA that reduces receptor transcriptional activity, ele...	Fitness & Body	Triglycerides	Moderate
rs738409	PNPLA3 I148M	Strongest genetic risk factor for non-alcoholic fatty liver disease, progress...	Liver Fat	Triglycerides	Established
rs662799	APOA5 -1131T>C	Promoter variant that reduces APOA5 expression, impairing lipoprotein lipase ...	Atherogenic Lipoproteins	Triglycerides	Strong
rs780094	GCKR	Intronic GCKR variant in strong LD with the coding P446L substitution (rs1260...	Liver Fat	Triglycerides	Strong
rs17482753	LPL LPL G>T (Intergenic Variant)	Intergenic variant near the lipoprotein lipase gene on 8p21.3 with an indepen...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs693	APOB XbaI (C/T)	Silent variant affecting LDL particle number and lipid metabolism; A allele c...	Atherogenic Lipoproteins	Triglycerides	Strong
rs2575876	ABCA1	Intronic ABCA1 variant associated with HDL-C levels under a recessive model; ...	Cholesterol & Lipoproteins	Triglycerides	Moderate
rs2000813	LIPG	Missense variant in endothelial lipase that tags a regulatory haplotype assoc...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs2073658	USF1 USF1 FCHL Variant	Intronic USF1 variant; the T allele disrupts insulin-responsive USF1 regulati...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs2197089	LPL LPL Regulatory Variant	Downstream regulatory variant affecting LPL expression and triglyceride clear...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs2542052	APOC3	Promoter variant that reduces APOC3 expression, associated with lower triglyc...	Longevity & Aging	Triglycerides	Strong
rs2278236	ANGPTL4 ANGPTL4 Intronic Variant	Intronic ANGPTL4 variant tagging reduced LPL inhibition; the A allele is asso...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs2524299	FADS2	Intronic regulatory variant in FADS2 (Block 2 haplotype) that reduces basal F...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs264	LPL LPL Intron 6 Variant	Intronic LPL variant associated with altered triglyceride clearance and HDL l...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs2605100	LYPLAL1	Intronic variant in the LYPLAL1 locus associated with waist-hip ratio and fat...	Fat Storage & Energy	Triglycerides	Strong
rs2854116	APOC3 T-455C	APOC3 promoter variant that disrupts insulin suppression of ApoC-III, raising...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs2854117	APOC3 APOC3 C-482T	Promoter variant in APOC3 disrupting insulin-responsive regulation of apolipo...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs2919872	FABP1 FABP1 Promoter Variant	Promoter variant 2 kb upstream of FABP1 (liver fatty acid binding protein) th...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs2954021	TRIB1	Near-gene variant influencing hepatic lipid metabolism; G allele raises trigl...	Triglycerides & Fatty Acids	Triglycerides	Established
rs3135506	APOA5 S19W	Triglyceride metabolism - affects fasting triglyceride levels and cardiovascu...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs7799039	LEP G-2548A	Promoter variant that increases leptin gene expression in adipose tissue, ele...	Appetite & Obesity	Triglycerides	Moderate
rs3774261	ADIPOQ ADIPOQ rs3774261	Intronic ADIPOQ variant that reduces circulating adiponectin levels in G alle...	Fat Storage & Energy	Triglycerides	Moderate
rs3816873	MTTP MTTP I128T	Missense variant in MTTP (microsomal triglyceride transfer protein) at residu...	Fat Storage & Energy	Triglycerides	Moderate
rs838880	SCARB1	3' UTR variant in SCARB1 that tags a haplotype with reduced SR-BI expression ...	Cholesterol & Lipoproteins	Triglycerides	Strong
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Blood Sugar & Diabetes	Triglycerides	Strong
rs3829462	LIPC	Missense variant in hepatic lipase encoding p.Phe356Leu; the rare C allele (P...	Triglycerides & Fatty Acids	Triglycerides	Emerging
rs3834458	FADS2	A 3-bp deletion in intron 3 of FADS2 that reduces delta-6 desaturase activity...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs4148102	ABCG1 ABCG1 intronic PUFA-interaction variant	Intronic variant in the ABCG1 cholesterol efflux transporter gene that modifi...	Triglycerides & Fatty Acids	Triglycerides	Emerging
rs4775065	LIPC	Intronic LIPC variant associated with susceptibility to low HDL-C and coronar...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs4939883	LOC105372112	Intronic variant near LIPG whose T allele increases circulating endothelial l...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs5082	APOA2 -265T>C	Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs57137919	ABCG1	ABCG1 promoter variant that reduces transporter expression, impairing macroph...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs692383	ABCG1 ABCG1 HDL-c Variant	Intronic variant in the ABCG1 cholesterol efflux transporter gene associated ...	Triglycerides & Fatty Acids	Triglycerides	Emerging
rs964184	ZNF259 ZNF259/BUD13 Triglyceride Variant	Common regulatory variant at the APOA5-ZNF259 locus; G allele reduces ApoAV p...	Triglycerides & Fatty Acids	Triglycerides	Strong
rs968567	FADS2 FADS2 Promoter D6D Activity Variant	Promoter variant in FADS2 that increases delta-6 desaturase (D6D) expression ...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs9951026	LIPG	Intronic LIPG variant that tags a haplotype associated with higher LDL choles...	Triglycerides & Fatty Acids	Triglycerides	Moderate
rs780095	GCKR GCKR Glucose-Lipid Regulation Variant	Intronic GCKR enhancer variant on the CGG regulatory haplotype; the G allele ...	Blood Sugar & Diabetes	Triglycerides	Moderate
rs780096	GCKR GCKR Metabolic Balance Variant	Intronic GCKR enhancer variant that modulates FOXA2-driven GCKR expression in...	Blood Sugar & Diabetes	Triglycerides	Moderate