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rs9536314
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KLOTHO
F352V (KL-VS)
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Longevity-associated variant exhibiting overdominance where heterozygotes sho...
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Longevity & Aging
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Strong
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rs429358
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APOE
E4 determinant
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Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high sat...
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Nutrition & Metabolism
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Established
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rs17070145
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WWC1
Intronic C>T
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Influences episodic memory performance and hippocampal function through the K...
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Brain & Mental Health
|
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Moderate
|
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rs5882
|
CETP
I405V
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Missense variant that reduces CETP enzyme activity, raising HDL-C and enlargi...
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Longevity & Aging
|
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Moderate
|
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rs744373
|
BIN1
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Second strongest genetic risk factor for Alzheimer's disease after APOE, asso...
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Brain & Mental Health
|
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Established
|
|
rs11136000
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CLU
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Intronic variant in clusterin gene affecting Alzheimer's disease risk through...
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Brain & Mental Health
|
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Established
|
|
rs75932628
|
TREM2
R47H
|
Rare missense variant in microglial receptor TREM2 that significantly increas...
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Brain & Mental Health
|
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Established
|
|
rs3851179
|
PICALM
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Variant in the PICALM gene affecting amyloid-beta clearance across the blood-...
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Brain & Mental Health
|
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Established
|
|
rs17649553
|
MAPT
H1/H2 Haplotype Tag
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Haplotype-tagging variant distinguishing MAPT H1 and H2 clades, affecting ris...
|
Brain & Mental Health
|
|
Strong
|
|
rs2069837
|
IL6
|
Intronic IL6 enhancer variant that regulates the anti-inflammatory gene GPNMB...
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Longevity & Aging
|
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Moderate
|
|
rs1800547
|
MAPT
H1/H2 Haplotype Splice Regulator
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Intronic MAPT variant that regulates tau exon 3 splicing via hnRNP F/Q bindin...
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Brain & Mental Health
|
|
Strong
|
|
rs1524107
|
IL6
|
Intronic IL6 variant tagging a low-producing haplotype — the T allele is prot...
|
Longevity & Aging
|
|
Moderate
|
|
rs1937
|
TFAM
S12T
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Missense variant in the TFAM mitochondrial targeting sequence — the C allele ...
|
Longevity & Aging
|
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Moderate
|