Tag

Alzheimer's

8 genetic variants with this tag.

RSID	Gene	Description	Category
rs429358	APOE E4 determinant	Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high sat...	Nutrition & Metabolism	Cholesterol Cardiovascular Alzheimer's	Established
rs17070145	WWC1 Intronic C>T	Influences episodic memory performance and hippocampal function through the K...	Brain & Mental Health	Cognition Memory Alzheimer's	Moderate
rs9536314	KLOTHO F352V (KL-VS)	Longevity-associated variant exhibiting overdominance where heterozygotes sho...	Heart & Inflammation	Mental Health Longevity Cardiovascular	Strong
rs744373	BIN1	Second strongest genetic risk factor for Alzheimer's disease after APOE, asso...	Brain & Mental Health	Alzheimer's Neurological Risk Memory	Established
rs11136000	CLU	Intronic variant in clusterin gene affecting Alzheimer's disease risk through...	Brain & Mental Health	Alzheimer's Neurological Risk Cardiovascular	Established
rs75932628	TREM2 R47H	Rare missense variant in microglial receptor TREM2 that significantly increas...	Brain & Mental Health	Alzheimer's Neurological Risk Neuroinflammation	Established
rs3851179	PICALM	Variant in the PICALM gene affecting amyloid-beta clearance across the blood-...	Brain & Mental Health	Alzheimer's Neurological Risk Cardiovascular	Established
rs17649553	MAPT H1/H2 Haplotype Tag	Haplotype-tagging variant distinguishing MAPT H1 and H2 clades, affecting ris...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong