Tag

Antidepressants

13 genetic variants with this tag.

RSID	Gene	Description	Category
rs3892097	CYP2D6 *4	Major enzyme for metabolizing ~25% of medications including opioids, antidepr...	Pharmacogenomics	Drug Metabolism Antidepressants Pain Medication	Established
rs1065852	CYP2D6 *10	Decreased function CYP2D6 variant common in Asian populations	Pharmacogenomics	Drug Metabolism Antidepressants Pain Medication	Established
rs4244285	CYP2C19 *2	No-function CYP2C19 variant affecting PPIs, clopidogrel, and some antidepress...	Pharmacogenomics	Drug Metabolism Blood Thinners Proton Pump Inhibitors	Established
rs12248560	CYP2C19 *17	Increased function CYP2C19 variant - rapid/ultrarapid metabolizer	Pharmacogenomics	Drug Metabolism Proton Pump Inhibitors Antidepressants	Established
rs1360780	FKBP5 Intronic C>T	Co-chaperone of the glucocorticoid receptor that regulates cortisol feedback ...	Brain & Mental Health	Stress Cognition Cortisol	Strong
rs6311	HTR2A -1438G>A	Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects ...	Brain & Mental Health	Mental Health Antidepressants Neurotransmitters	Moderate
rs16947	CYP2D6 *2	Common CYP2D6 variant defining the *2 allele; previously considered normal-fu...	Pharmacogenomics	Pharmacogenomics Drug Metabolism Antidepressants	Strong
rs25531	SLC6A4 A>G	Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and...	Brain & Mental Health	Mental Health Neurotransmitters Antidepressants	Moderate
rs5030655	CYP2D6 *6	Frameshift deletion causing no enzyme function, defining poor metabolizer sta...	Pharmacogenomics	Drug Metabolism Pain Medication Antidepressants	Established
rs28371725	CYP2D6 *41	Intronic splice variant causing decreased CYP2D6 enzyme activity through aber...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Pain Medication	Established
rs3745274	CYP2B6 516G>T	Decreased-function variant affecting metabolism of efavirenz, methadone, bupr...	Pharmacogenomics	Drug Metabolism Antidepressants Pain Medication	Established
rs5443	GNB3 C825T	Synonymous exon-10 variant that triggers alternative splicing of the G-protei...	Hormones & Sleep	Hypertension Blood Pressure Antidepressants	Strong
rs35599367	CYP3A4 *22	Intronic splice variant causing ~50% reduced CYP3A4 mRNA expression, affectin...	Pharmacogenomics	Drug Metabolism Statins Immunosuppressants	Established