Tag

Antidepressants

32 genetic variants with this tag.

RSID	Gene	Description	Category
rs10403955	CYP2B6	Intronic CYP2B6 haplotype-tagging variant associated with altered plasma conc...	Pharmacogenomics	Antidepressants	Moderate
rs1058164	CYP2D6	Synonymous CYP2D6 variant that promotes exon 3 skipping, reducing functional ...	Pharmacogenomics	Antidepressants	Moderate
rs1065852	CYP2D6 *10	Decreased function CYP2D6 variant common in Asian populations	Pharmacogenomics	Antidepressants	Established
rs1360780	FKBP5 Intronic C>T	Co-chaperone of the glucocorticoid receptor that regulates cortisol feedback ...	Mood & Behavior	Antidepressants	Strong
rs1080985	CYP2D6 *2A promoter	CYP2D6 promoter variant (-1584C>G) that reduces enzyme expression; the C alle...	Pharmacogenomics	Antidepressants	Strong
rs1387923	NTRK2 NTRK2/TrkB 3'UTR variant	3' UTR variant in the TrkB receptor gene affecting NTRK2 expression; associat...	Mood & Behavior	Antidepressants	Moderate
rs12248560	CYP2C19 *17	Increased function CYP2C19 variant - rapid/ultrarapid metabolizer	Pharmacogenomics	Antidepressants	Established
rs1800544	ADRA2A ADRA2A Promoter -1291C>G	Promoter variant that alters alpha-2A adrenergic receptor expression, affecti...	Appetite & Obesity	Antidepressants	Moderate
rs12721627	CYP3A4 *16	Missense variant reducing CYP3A4 enzyme activity by 50–74% depending on subst...	Pharmacogenomics	Antidepressants	Moderate
rs16947	CYP2D6 *2	Common CYP2D6 variant defining the *2 allele; previously considered normal-fu...	Pharmacogenomics	Antidepressants	Strong
rs2371365	PCLO PCLO Presynaptic Scaffold	Intronic variant in the presynaptic scaffold gene PCLO linked to altered mono...	Mood & Behavior	Antidepressants	Moderate
rs2522833	PCLO Ser4814Ala	Missense variant in the C2A calcium-binding domain of presynaptic scaffolding...	Mood & Behavior	Antidepressants	Moderate
rs25531	SLC6A4 A>G	Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and...	Mood & Behavior	Antidepressants	Moderate
rs2069526	CYP1A2 -739T>G	Intronic CYP1A2 variant near the 5' end; G allele is associated with altered ...	Pharmacogenomics	Antidepressants	Emerging
rs6295	HTR1A C-1019G	Functional promoter variant in the serotonin 1A receptor gene that increases ...	Mood & Behavior	Antidepressants	Strong
rs6311	HTR2A -1438G>A	Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects ...	Mood & Behavior	Antidepressants	Moderate
rs28371706	CYP2D6 *17	Decreased-function CYP2D6 allele common in African populations, reducing meta...	Pharmacogenomics	Antidepressants	Established
rs28371725	CYP2D6 *41	Intronic splice variant causing decreased CYP2D6 enzyme activity through aber...	Pharmacogenomics	Antidepressants	Established
rs28371733	CYP2D6	Rare CYP2D6 stop-gain variant (Glu418Ter) that eliminates enzyme activity, ca...	Pharmacogenomics	Antidepressants	Established
rs28695233	CYP2D6	Deep intronic CYP2D6 variant in intron 2 that serves as a haplotype tag in sp...	Pharmacogenomics	Antidepressants	Emerging
rs35599367	CYP3A4 *22	Intronic splice variant causing ~50% reduced CYP3A4 mRNA expression, affectin...	Pharmacogenomics	Antidepressants	Established
rs373489637	CYP2B6 V183G	Near-complete loss-of-function CYP2B6 variant causing severely impaired metab...	Pharmacogenomics	Antidepressants	Moderate
rs3745274	CYP2B6 516G>T	Decreased-function variant affecting metabolism of efavirenz, methadone, bupr...	Pharmacogenomics	Antidepressants	Established
rs3758581	CYP2C19 Ile331Val (CYP2C19*1B)	Common CYP2C19 missense variant defining the *1B allele; the G (Val331) allel...	Pharmacogenomics	Antidepressants	Moderate
rs5443	GNB3 C825T	Synonymous exon-10 variant that triggers alternative splicing of the G-protei...	Hormones & Sleep	Antidepressants	Strong
rs3892097	CYP2D6 *4	CYP2D6 *4 splice-defect null allele — the most common loss-of-function CYP2D6...	Pharmacogenomics	Antidepressants	Established
rs4244285	CYP2C19 *2	No-function CYP2C19 variant affecting PPIs, clopidogrel, and some antidepress...	Pharmacogenomics	Antidepressants	Established
rs4986893	CYP2C19 *3	No-function CYP2C19 stop-gain variant — second most common loss-of-function a...	Pharmacogenomics	Antidepressants	Established
rs5030655	CYP2D6 *6	Frameshift deletion causing no enzyme function, defining poor metabolizer sta...	Pharmacogenomics	Antidepressants	Established
rs58440431	CYP2D6	Intronic CYP2D6 variant tagging East Asian *10-lineage suballeles; the C alle...	Pharmacogenomics	Antidepressants	Strong
rs71328650	CYP2D6	Intronic CYP2D6 haplotype tag variant (rs28371702 canonical form) associated ...	Pharmacogenomics	Antidepressants	Emerging
rs72549354	CYP2D6 *20	Frameshift insertion creating a null CYP2D6 allele; carriers cannot metaboliz...	Pharmacogenomics	Antidepressants	Established