Tag

Cancer Treatment

5 genetic variants with this tag.

RSID	Gene	Description	Category
rs3918290	DPYD *2A	Most critical pharmacogenomic variant causing complete loss of DPD enzyme fun...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Chemotherapy	Established
rs67376798	DPYD D949V	Decreased-function variant reducing DPD enzyme activity ~30%, requiring 50% f...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Chemotherapy	Established
rs4148323	UGT1A1 *6 Gly71Arg	Phase II glucuronidation enzyme that metabolizes bilirubin and many drugs inc...	Pharmacogenomics	Pharmacogenomics Drug Metabolism Chemotherapy	Established
rs116855232	NUDT15 Arg139Cys	Nucleotide diphosphatase that inactivates toxic thiopurine metabolites; reduc...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Chemotherapy	Established
rs396991	FCGR3A V158F	Missense variant in Fc gamma receptor IIIa (CD16a) that determines NK cell Ig...	Immune & Gut	Immune & Gut Pharmacogenomics Innate Immunity	Strong