Tag
Cancer Treatment
12 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs116855232 | NUDT15 Arg139Cys | Nucleotide diphosphatase that inactivates toxic thiopurine metabolites; reduc... | Pharmacogenomics | Established | |
| rs1341162 | CYP2C8 | Intronic CYP2C8 haplotype-tagging variant linked to bisphosphonate-related os... | Pharmacogenomics | Moderate | |
| rs1341164 | CYP2C8 | Intronic CYP2C8 variant tagging a haplotype associated with altered taxane dr... | Pharmacogenomics | Emerging | |
| rs1934951 | CYP2C8 | Intronic CYP2C8 variant associated with paclitaxel-induced toxicity and bisph... | Pharmacogenomics | Moderate | |
| rs396991 | FCGR3A V158F | Missense variant in Fc gamma receptor IIIa (CD16a) that determines NK cell Ig... | Innate Immunity & Infection Defense | Strong | |
| rs1934980 | CYP2C8 | Intronic CYP2C8 variant associated with bisphosphonate-related jaw complicati... | Pharmacogenomics | Moderate | |
| rs28399433 | CYP2A6 *9 (TATA box) | Promoter variant that reduces CYP2A6 expression by ~50%, slowing nicotine met... | Pharmacogenomics | Strong | |
| rs3918290 | DPYD *2A | Most critical pharmacogenomic variant causing complete loss of DPD enzyme fun... | Pharmacogenomics | Established | |
| rs4148323 | UGT1A1 *6 Gly71Arg | Phase II glucuronidation enzyme that metabolizes bilirubin and many drugs inc... | Pharmacogenomics | Established | |
| rs55886062 | DPYD *13 | No-function DPYD star allele (I560S) causing severe DPD deficiency; one of fo... | Pharmacogenomics | Established | |
| rs56038477 | DPYD HapB3 tag (c.1236G>A, E412E) | Synonymous exon-11 tag SNP for the DPYD HapB3 haplotype; benign on its own bu... | Pharmacogenomics | Established | |
| rs67784355 | CYP3A4 *11 (Thr363Met) | Rare missense variant in CYP3A4 that reduces protein expression and enzymatic... | Pharmacogenomics | Emerging |