Tag

Chemotherapy

14 genetic variants with this tag.

RSID	Gene	Description	Category
rs1045642	ABCB1 C3435T	Synonymous variant in P-glycoprotein affecting drug efflux pump expression an...	Pharmacogenomics	Chemotherapy	Moderate
rs1113129	CYP2C8	Intronic tagging SNP for CYP2C8 haplotype C, a low-activity haplotype associa...	Pharmacogenomics	Chemotherapy	Moderate
rs2303428	MSH2	Splice-region variant in MSH2 (c.2006-6T>C) located 6 bases upstream of exon ...	Gamete Quality & DNA Repair	Chemotherapy	Moderate
rs1051298	SLC19A1 SLC19A1 3'UTR variant (c.*746C>T)	3'UTR variant in the folate transporter gene affecting pemetrexed toxicity ri...	Methylation & Detox	Chemotherapy	Moderate
rs116855232	NUDT15 Arg139Cys	Nucleotide diphosphatase that inactivates toxic thiopurine metabolites; reduc...	Pharmacogenomics	Chemotherapy	Established
rs12721629	CYP3A4 *16B	Missense variant causing substrate-dependent reduced CYP3A4 activity, most pr...	Pharmacogenomics	Chemotherapy	Moderate
rs1341164	CYP2C8	Intronic CYP2C8 variant tagging a haplotype associated with altered taxane dr...	Pharmacogenomics	Chemotherapy	Emerging
rs1934951	CYP2C8	Intronic CYP2C8 variant associated with paclitaxel-induced toxicity and bisph...	Pharmacogenomics	Chemotherapy	Moderate
rs3918290	DPYD *2A	Most critical pharmacogenomic variant causing complete loss of DPD enzyme fun...	Pharmacogenomics	Chemotherapy	Established
rs4148323	UGT1A1 *6 Gly71Arg	Phase II glucuronidation enzyme that metabolizes bilirubin and many drugs inc...	Pharmacogenomics	Chemotherapy	Established
rs55886062	DPYD *13	No-function DPYD star allele (I560S) causing severe DPD deficiency; one of fo...	Pharmacogenomics	Chemotherapy	Established
rs56038477	DPYD HapB3 tag (c.1236G>A, E412E)	Synonymous exon-11 tag SNP for the DPYD HapB3 haplotype; benign on its own bu...	Pharmacogenomics	Chemotherapy	Established
rs67376798	DPYD D949V	Decreased-function variant reducing DPD enzyme activity ~30%, requiring 50% f...	Pharmacogenomics	Chemotherapy	Established
rs75017182	DPYD HapB3 (c.1129-5923C>G)	Deep intronic splice-site variant that is the functional driver of the DPYD H...	Pharmacogenomics	Chemotherapy	Established