Tag
Chemotherapy
9 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1045642 | ABCB1 C3435T | Synonymous variant in P-glycoprotein affecting drug efflux pump expression an... | Pharmacogenomics | Moderate | |
| rs2303428 | MSH2 | Splice-region variant in MSH2 (c.2006-6T>C) located 6 bases upstream of exon ... | Gamete Quality & DNA Repair | Moderate | |
| rs116855232 | NUDT15 Arg139Cys | Nucleotide diphosphatase that inactivates toxic thiopurine metabolites; reduc... | Pharmacogenomics | Established | |
| rs1341164 | CYP2C8 | Intronic CYP2C8 variant tagging a haplotype associated with altered taxane dr... | Pharmacogenomics | Emerging | |
| rs1934951 | CYP2C8 | Intronic CYP2C8 variant associated with paclitaxel-induced toxicity and bisph... | Pharmacogenomics | Moderate | |
| rs3918290 | DPYD *2A | Most critical pharmacogenomic variant causing complete loss of DPD enzyme fun... | Pharmacogenomics | Established | |
| rs4148323 | UGT1A1 *6 Gly71Arg | Phase II glucuronidation enzyme that metabolizes bilirubin and many drugs inc... | Pharmacogenomics | Established | |
| rs55886062 | DPYD *13 | No-function DPYD star allele (I560S) causing severe DPD deficiency; one of fo... | Pharmacogenomics | Established | |
| rs56038477 | DPYD HapB3 tag (c.1236G>A, E412E) | Synonymous exon-11 tag SNP for the DPYD HapB3 haplotype; benign on its own bu... | Pharmacogenomics | Established |