Tag

Circadian

37 genetic variants with this tag.

RSID	Gene	Description	Category
rs10462020	PER3 V647G	Missense variant in circadian clock gene PER3 associated with morning chronot...	Hormones & Sleep	Circadian	Moderate
rs10830963	MTNR1B Intron C>G	Melatonin receptor variant that extends nighttime melatonin signaling in panc...	Hormones & Sleep	Circadian	Established
rs11071559	RORA	Intronic variant in the circadian clock regulator RORA; the T allele is prote...	Allergy & Atopic Disease	Circadian	Moderate
rs1144566	RGS16 RGS16 H137R	Missense variant in RGS16 that substitutes histidine for arginine at position...	Hormones & Sleep	Circadian	Moderate
rs11545787	RASD1 RASD1 photic entrainment variant	3' UTR variant in RASD1 (Dexras1), a GTPase that gates light signals to the c...	Hormones & Sleep	Circadian	Strong
rs11605924	CRY2 Intron Variant	Circadian clock gene variant affecting fasting glucose, hepatic lipid metabol...	Hormones & Sleep	Circadian	Strong
rs12736689	RGS16	Intronic/regulatory variant near RGS16 that is the strongest single-locus mor...	Hormones & Sleep	Circadian	Strong
rs1369481	NPAS2	Intronic variant in the brain-specific circadian transcription factor NPAS2; ...	Hormones & Sleep	Circadian	Emerging
rs139315125	PER3 H417R	Rare PER3 missense variant that co-occurs on the FASPS3 haplotype with Pro415...	Hormones & Sleep	Circadian	Strong
rs57875989	PER3 PER3 VNTR (4/5 repeat)	Coding VNTR in exon 18 of the circadian clock gene PER3; 4-repeat vs 5-repeat...	Arrhythmia & Heart Rhythm	Circadian	Moderate
rs150812083	PER3 PER3 Pro415Ala (FASPS3)	Rare PER3 missense variant that destabilizes the circadian clock protein, sho...	Hormones & Sleep	Circadian	Strong
rs1554483	CLOCK	Intronic CLOCK variant whose G allele, in a haplotype with rs4864548 A, confe...	Hormones & Sleep	Circadian	Moderate
rs1801260	CLOCK 3111T>C (3'UTR)	Core circadian clock transcription factor variant affecting mRNA stability, a...	Hormones & Sleep	Circadian	Moderate
rs184039278	CRY1 CRY1Δ11	Splice-site variant in the circadian clock gene CRY1 that causes exon 11 skip...	Hormones & Sleep	Circadian	Strong
rs1562444	MTNR1B MTNR1B 3'UTR Melatonin Signaling Variant	Regulatory 3'UTR variant in the melatonin receptor 1B gene that affects MTNR1...	Blood Sugar & Diabetes	Circadian	Moderate
rs2050122	HTR6	Regulatory variant near the HTR6 serotonin 6 receptor gene associated with ch...	Hormones & Sleep	Circadian	Moderate
rs2066853	AHR Arg554Lys	Aryl hydrocarbon receptor variant in the transactivation domain that alters A...	Hormones & Sleep	Circadian	Moderate
rs228697	PER3 Pro864Ala	Core clock gene variant that shifts circadian period length and influences mo...	Hormones & Sleep	Circadian	Moderate
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Circadian	Strong
rs2304672	PER2 5'UTR C111G	Regulatory variant in a core clock gene that influences circadian timing, sle...	Hormones & Sleep	Circadian	Moderate
rs2675703	OPN4	Missense variant (Pro10Leu) in melanopsin, the photopigment driving circadian...	Hormones & Sleep	Circadian	Emerging
rs324981	NPSR1 Asn107Ile	Gain-of-function missense variant in the neuropeptide S receptor that increas...	Hormones & Sleep	Circadian	Moderate
rs34714364	APH1A APH1A gamma-secretase variant	Synonymous variant in CA14 near APH1A; T allele is associated with morning ch...	Hormones & Sleep	Circadian	Moderate
rs34903499	VIP	Synonymous coding variant in the VIP gene (Asn133Asn); the T allele may alter...	Hormones & Sleep	Circadian	Emerging
rs35333999	PER2 V903I	Missense variant in core circadian clock gene PER2 that lengthens intrinsic c...	Hormones & Sleep	Circadian	Strong
rs35833281	HCRTR2	Intronic variant in the orexin/hypocretin receptor 2 gene that tags the HCRTR...	Hormones & Sleep	Circadian	Strong
rs3754048	APH1A -980C/G	Regulatory variant 2 kb upstream of APH1A where the C allele (paper's G, codi...	Hormones & Sleep	Circadian	Moderate
rs3923809	BTBD9	Second independent intronic BTBD9 variant associated with restless legs syndr...	Hormones & Sleep	Circadian	Strong
rs4410790	AHR	Regulatory variant 54 kb upstream of the aryl hydrocarbon receptor gene; the ...	Hormones & Sleep	Circadian	Strong
rs4446909	ASMT Promoter A>G	Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression...	Hormones & Sleep	Circadian	Moderate
rs4753426	MTNR1B	Promoter variant in the melatonin receptor 1B gene that alters MTNR1B express...	Hormones & Sleep	Circadian	Moderate
rs516134	RGS16 RGS16 chronotype variant	Regulatory variant ~20 kb downstream of RGS16 that influences circadian chron...	Hormones & Sleep	Circadian	Strong
rs55694368	PER2 PER2 regulatory variant	Upstream regulatory signal near the core circadian clock gene PER2 that shift...	Hormones & Sleep	Circadian	Strong
rs757081	NUCB2 Gln338Glu (Q338E)	Missense variant in nucleobindin-2, the precursor protein cleaved to produce ...	Hormones & Sleep	Circadian	Moderate
rs9394502	BTBD9 BTBD9 insomnia/RLS variant	Intronic variant in the canonical restless legs syndrome gene BTBD9, associat...	Hormones & Sleep	Circadian	Strong
rs9479402	VIP VIP chronotype variant	Intergenic variant ~54 kb downstream of the VIP gene; the C allele reduces VI...	Hormones & Sleep	Circadian	Strong
rs9565309	FBXL3 FBXL3 circadian variant	Regulatory variant near FBXL3 that modulates circadian period length; the C a...	Hormones & Sleep	Circadian	Strong