Tag

Cognition

32 genetic variants with this tag.

RSID	Gene	Description	Category
rs1019385	GRIN2B	Promoter variant in the GRIN2B Sp1 binding site that reduces NR2B subunit exp...	Neurology & Cognition	Cognition	Moderate
rs11599236	SORCS3 SORCS3 Neurotrophin Sorting	Intronic variant in the BDNF-receptor trafficking gene SORCS3, associated wit...	Mood & Behavior	Cognition	Strong
rs12606138	NEDD4L	Intronic variant in NEDD4L associated with reading ability and dyslexia susce...	Blood Pressure & Hypertension	Cognition	Moderate
rs1279683	SLC23A2	Intronic variant in the SVCT2 vitamin C transporter — G allele associated wit...	Vitamins & Nutrient Absorption	Cognition	Moderate
rs1360780	FKBP5 Intronic C>T	Co-chaperone of the glucocorticoid receptor that regulates cortisol feedback ...	Mood & Behavior	Cognition	Strong
rs1064395	NCAN	3' UTR variant in the neurocan gene associated with bipolar disorder and schi...	Neurology & Cognition	Cognition	Strong
rs1080985	CYP2D6 *2A promoter	CYP2D6 promoter variant (-1584C>G) that reduces enzyme expression; the C alle...	Pharmacogenomics	Cognition	Strong
rs1545843	SLC6A15 SLC6A15 depression risk variant	Intronic variant reducing SLC6A15 expression in hippocampus; AA carriers show...	Mood & Behavior	Cognition	Strong
rs1611115	DBH -1021C>T	Strongest known genetic determinant of dopamine beta-hydroxylase activity, co...	Mood & Behavior	Cognition	Strong
rs11713169	NLGN1	Intronic variant in neuroligin 1, a postsynaptic cell adhesion molecule essen...	Neurology & Cognition	Cognition	Strong
rs1800497	DRD2/ANKK1 TaqIA (Glu713Lys)	Reduces dopamine D2 receptor density in the striatum, affecting reward proces...	Mood & Behavior	Cognition	Strong
rs1800883	HTR5A	Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting recep...	Mood & Behavior	Cognition	Moderate
rs1800955	DRD4 -521C>T	Promoter variant that modulates dopamine D4 receptor expression in the prefro...	Mood & Behavior	Cognition	Moderate
rs34579341	NEGR1 NEGR1 Neuronal Growth Regulator	Intronic tag SNP in NEGR1 affecting neuronal cell adhesion, hippocampal neuro...	Mood & Behavior	Cognition	Strong
rs17070145	WWC1 Intronic C>T	Influences episodic memory performance and hippocampal function through the K...	Neurology & Cognition	Cognition	Moderate
rs17518584	CADM2	Intronic CADM2 variant genome-wide significant for information processing spe...	Neurology & Cognition	Cognition	Moderate
rs4149268	ABCA1	Intronic ABCA1 variant — the C allele tags a liver enhancer that boosts ABCA1...	Cholesterol & Lipoproteins	Cognition	Moderate
rs53576	OXTR Intronic A>G	Most-studied oxytocin receptor variant, influencing empathy, social sensitivi...	Mood & Behavior	Cognition	Moderate
rs1784931	SORL1 SORL1 intron 39 variant	Intronic variant in the sortilin-related receptor that tags a 3′ haplotype bl...	Neurology & Cognition	Cognition	Moderate
rs1906252	POU3F2	Regulatory variant at chromosome 6q16.1 near POU3F2 (BRN2), a master transcri...	Neurology & Cognition	Cognition	Strong
rs73034295	IGSF9B IGSF9B Inhibitory Synapse Adhesion	Intronic variant in the gene encoding the inhibitory synaptic adhesion protei...	Mood & Behavior	Cognition	Emerging
rs202676	FOLH1 T484A	Reduces intestinal folate hydrolase activity, impairing absorption of dietary...	Methylation & Detox	Cognition	Moderate
rs2274319	MEF2D	Intronic variant in MEF2D encoding a key neuronal transcription factor that r...	Neurology & Cognition	Cognition	Strong
rs4307059	CDH9/CDH10	Intergenic variant at 5p14.1 between neuronal cell-adhesion genes CDH9 and CD...	Hormones & Sleep	Cognition	Strong
rs4532	DRD1	Regulatory 5'UTR variant in the dopamine D1 receptor gene influencing recepto...	Neurology & Cognition	Cognition	Moderate
rs4851266	AFF3	Intronic variant in the super elongation complex gene AFF3; the T allele incr...	Neurology & Cognition	Cognition	Strong
rs61734410	CACNA1H Pro640Leu	Missense variant in CACNA1H encoding the CaV3.2 T-type calcium channel; the L...	Neurology & Cognition	Cognition	Moderate
rs6265	BDNF Val66Met	Key neurotrophin variant that controls activity-dependent BDNF release, affec...	Neurology & Cognition	Cognition	Strong
rs638405	BACE1 BACE1 Exon 5 Synonymous Variant	Synonymous variant in BACE1 (beta-secretase 1) linked to modestly elevated Al...	Neurology & Cognition	Cognition	Moderate
rs6439886	CLSTN2	Intronic variant in the calsyntenin-2 gene associated with episodic memory pe...	Neurology & Cognition	Cognition	Moderate
rs6833641	ARAP2	Intergenic variant near ARAP2 associated with motion sickness susceptibility ...	Neurology & Cognition	Cognition	Strong
rs9320913	POU3F2	Intergenic regulatory variant upstream of POU3F2 (BRN-2), a transcription fac...	Neurology & Cognition	Cognition	Strong