Tag

Folate

37 genetic variants with this tag.

RSID	Gene	Description	Category
rs10380	MTRR His595Tyr	Missense variant in methionine synthase reductase that impairs B12 reactivati...	Methylation & Detox	Folate	Moderate
rs1051266	SLC19A1 G80A (His27Arg)	Folate transporter — how well folate gets into your cells	Methylation & Detox	Folate	Moderate
rs1051296	SLC19A1 SLC19A1 variant (RFC1)	3'UTR variant in the reduced folate carrier that affects miR-595 binding, alt...	Methylation & Detox	Folate	Moderate
rs1051298	SLC19A1 SLC19A1 3'UTR variant (c.*746C>T)	3'UTR variant in the folate transporter gene affecting pemetrexed toxicity ri...	Methylation & Detox	Folate	Moderate
rs10925239	MTR	Deep intronic MTR variant associated with reduced cleft lip/palate risk via l...	Methylation & Detox	Folate	Emerging
rs10925254	MTR	Deep intronic MTR variant associated with reduced cleft lip/palate risk via l...	Methylation & Detox	Folate	Emerging
rs10925260	MTR	Intronic MTR variant associated with altered methionine synthase expression a...	Methylation & Detox	Folate	Emerging
rs11545076	GGH -124T>G	Promoter variant that increases GGH expression, accelerating hydrolysis of in...	Methylation & Detox	Folate	Moderate
rs11627387	MTHFD1	Intronic variant in the cytoplasmic trifunctional folate enzyme MTHFD1, assoc...	Methylation & Detox	Folate	Moderate
rs12659	SLC19A1	Synonymous variant in the folate transporter SLC19A1 — a haplotype tag linked...	Methylation & Detox	Folate	Emerging
rs13420827	DNMT3A	3' UTR variant in the de novo DNA methyltransferase DNMT3A, associated with a...	Methylation & Detox	Folate	Emerging
rs1532268	MTRR MTRR S175L	Missense variant in methionine synthase reductase that raises homocysteine wh...	Methylation & Detox	Folate	Moderate
rs3760775	FUT6	Near-gene regulatory variant near FUT6 that reduces fucosyltransferase expres...	Vitamins & Nutrient Absorption	Folate	Moderate
rs162049	MTRR	Intronic MTRR variant associated with reduced enzyme expression and impaired ...	Methylation & Detox	Folate	Emerging
rs1800909	GGH c.16T>C (p.Cys6Arg)	Signal-peptide missense variant that alters GGH subcellular targeting; C alle...	Methylation & Detox	Folate	Moderate
rs1801131	MTHFR A1298C	Second MTHFR variant affecting enzyme activity in the regulatory domain	Methylation & Detox	Folate	Moderate
rs1801133	MTHFR C677T	Key enzyme for converting folate to its active methylfolate form	Methylation & Detox	Folate	Established
rs6922269	MTHFD1L	Intronic variant in the mitochondrial folate enzyme MTHFD1L, associated with ...	Coronary Artery Disease & Atherosclerosis	Folate	Strong
rs1802059	MTRR	Synonymous MTRR variant (c.1911G>A) associated with congenital heart disease ...	Methylation & Detox	Folate	Emerging
rs61735836	FTCD	Missense variant in the FTCD enzyme that impairs one-carbon unit transfer fro...	Vitamins & Nutrient Absorption	Folate	Strong
rs1979277	SHMT1 C1420T	Alters one-carbon metabolism and folate distribution; influences cancer risk,...	Methylation & Detox	Folate	Moderate
rs202676	FOLH1 T484A	Reduces intestinal folate hydrolase activity, impairing absorption of dietary...	Methylation & Detox	Folate	Moderate
rs202720	FOLH1	Intronic variant in the intestinal folate-cleaving enzyme FOLH1 (GCPII); the ...	Methylation & Detox	Folate	Emerging
rs2073067	MTHFD1L MTHFD1L variant	Intronic variant in the mitochondrial folate enzyme MTHFD1L, associated with ...	Methylation & Detox	Folate	Moderate
rs2236224	MTHFD1 MTHFD1 R653Q	Intronic tag variant in MTHFD1 in strong LD with the R653Q missense variant, ...	Methylation & Detox	Folate	Moderate
rs2236225	MTHFD1 G1958A	Folate processing enzyme — reduced stability increases choline need	Methylation & Detox	Folate	Strong
rs234706	CBS C699T	Common synonymous variant in the CBS gene associated with reduced cardiovascu...	Methylation & Detox	Folate	Moderate
rs2838956	SLC19A1 RFC1 intronic variant	Intronic SLC19A1 variant that tags a haplotype affecting reduced folate carri...	Methylation & Detox	Folate	Emerging
rs3776455	MTRR	Intronic MTRR variant associated with altered folate-pathway cancer risk and ...	Methylation & Detox	Folate	Emerging
rs3788189	SLC19A1 SLC19A1 IVS2 variant	Intronic variant in the folate transporter gene associated with pemetrexed tr...	Methylation & Detox	Folate	Emerging
rs3788200	SLC19A1 SLC19A1 intron 2 variant	Intronic SLC19A1 tag variant in strong LD with the G80A folate-transporter co...	Methylation & Detox	Folate	Moderate
rs3788205	SLC19A1 SLC19A1 intronic variant	Intronic marker in the folate transporter gene; tags SLC19A1 haplotype variat...	Methylation & Detox	Folate	Emerging
rs4659744	MTR MTR variant	Intronic MTR variant that tags the folate/B12-dependent remethylation locus a...	Methylation & Detox	Folate	Emerging
rs61886492	FOLH1 H475Y	Reduces intestinal GCPII enzyme activity by 53%, paradoxically raising circul...	Methylation & Detox	Folate	Strong
rs7946	PEMT Val175Met	Phosphatidylcholine production — affects dietary choline requirements	Methylation & Detox	Folate	Strong
rs828903	MTHFD2	Intronic variant in the mitochondrial folate enzyme MTHFD2, influencing one-c...	Methylation & Detox	Folate	Moderate
rs914232	SLC19A1 RFC1 -43T>C	Regulatory variant that reduces reduced folate carrier protein expression, im...	Methylation & Detox	Folate	Moderate