Tag

HDL Cholesterol

37 genetic variants with this tag.

RSID	Gene	Description	Category
rs1044317	ABCG1 ABCG1 3'UTR variant	3'UTR variant in ABCG1 that may reduce transporter expression, impairing chol...	Cholesterol & Lipoproteins	HDL Cholesterol	Moderate
rs10846744	SCARB1	Intronic SCARB1 variant associated with altered HDL-receptor function, subcli...	Cholesterol & Lipoproteins	HDL Cholesterol	Moderate
rs11057830	SCARB1	Intronic variant in SCARB1 that affects SR-BI receptor function and the intes...	Cholesterol & Lipoproteins	HDL Cholesterol	Moderate
rs12593008	LIPC	Intronic LIPC variant in intron 1 associated with low HDL risk, predominantly...	Triglycerides & Fatty Acids	HDL Cholesterol	Moderate
rs12678919	LPL	Intergenic variant 19 kb downstream of lipoprotein lipase (LPL) that tags a r...	Triglycerides & Fatty Acids	HDL Cholesterol	Strong
rs11568822	APOC1 APOC1 HCR-1 promoter variant	Promoter insertion variant in APOC1 that increases gene transcription by 50%,...	Cholesterol & Lipoproteins	HDL Cholesterol	Moderate
rs1378577	ABCG1 ABCG1 ischemic stroke variant	Regulatory variant ~2kb upstream of ABCG1 that modulates transporter expressi...	Atherogenic Lipoproteins	HDL Cholesterol	Moderate
rs13702	LPL	LPL 3'UTR variant disrupting a microRNA-410 binding site; the C allele abolis...	Triglycerides & Fatty Acids	HDL Cholesterol	Strong
rs150090666	PDE3B PDE3B R783X	Loss-of-function variant in phosphodiesterase 3B — carriers have enhanced cAM...	Triglycerides & Fatty Acids	HDL Cholesterol	Strong
rs1532085	LIPC	Intronic eQTL that reduces hepatic lipase expression, raising HDL-C levels wh...	Triglycerides & Fatty Acids	HDL Cholesterol	Strong
rs4149338	ABCA1 ABCA1 3'UTR Stroke-Associated Variant	3'UTR variant in the ATP-binding cassette transporter A1 gene; the G allele (...	Atherogenic Lipoproteins	HDL Cholesterol	Emerging
rs12686004	ABCA1	Intronic ABCA1 variant associated with population differences in HDL choleste...	Cholesterol & Lipoproteins	HDL Cholesterol	Emerging
rs1800775	CETP -629C>A	CETP promoter variant that reduces CETP expression via Sp1/Sp3 repression, ra...	Cholesterol & Lipoproteins	HDL Cholesterol	Strong
rs2943634	IRS1	Intergenic variant near IRS1 at 2q36.3 associated with ischemic stroke risk, ...	Coronary Artery Disease & Atherosclerosis	HDL Cholesterol	Moderate
rs2234714	ABCG1 ABCG1 promoter variant	Intronic ABCG1 variant near the promoter region; homozygous carriers of the m...	Cholesterol & Lipoproteins	HDL Cholesterol	Emerging
rs2249891	ABCA1	Intronic ABCA1 variant associated with lower HDL-cholesterol susceptibility a...	Cholesterol & Lipoproteins	HDL Cholesterol	Moderate
rs2575876	ABCA1	Intronic ABCA1 variant associated with HDL-C levels under a recessive model; ...	Cholesterol & Lipoproteins	HDL Cholesterol	Moderate
rs2237583	PON1 PON1 intron variant	Intronic PON1 variant that modulates arylesterase activity of the HDL-bound a...	Vascular Inflammation & Remodeling	HDL Cholesterol	Moderate
rs2853579	ABCA1	Synonymous coding variant in ABCA1 that tags a regulatory element influencing...	Cholesterol & Lipoproteins	HDL Cholesterol	Strong
rs519664	TTC39B TTC39B rs519664	Intronic variant in TTC39B (9p22) that increases endometriosis susceptibility...	Endometriosis & Uterine Health	HDL Cholesterol	Strong
rs2278236	ANGPTL4 ANGPTL4 Intronic Variant	Intronic ANGPTL4 variant tagging reduced LPL inhibition; the A allele is asso...	Triglycerides & Fatty Acids	HDL Cholesterol	Strong
rs4149268	ABCA1	Intronic ABCA1 variant — the C allele tags a liver enhancer that boosts ABCA1...	Cholesterol & Lipoproteins	HDL Cholesterol	Moderate
rs4149274	ABCA1	Intronic ABCA1 variant influencing HDL-cholesterol levels through altered ABC...	Cholesterol & Lipoproteins	HDL Cholesterol	Moderate
rs4783961	CETP	CETP promoter variant that raises HDL cholesterol by reducing cholesteryl est...	Cholesterol & Lipoproteins	HDL Cholesterol	Moderate
rs705379	PON1 PON1 promoter -108C>T	Promoter polymorphism that controls PON1 gene expression — the T allele (A on...	Vascular Inflammation & Remodeling	HDL Cholesterol	Strong
rs854555	PON1 PON1 3'UTR variant	Intronic/downstream PON1 haplotype-tagging variant associated with PON1 activ...	Vascular Inflammation & Remodeling	HDL Cholesterol	Emerging
rs854571	PON1 PON1 -108C>T promoter variant	Promoter variant that controls PON1 transcription; the T allele reduces PON1 ...	Vascular Inflammation & Remodeling	HDL Cholesterol	Strong
rs854572	PON1 PON1 promoter -909G>C	Promoter polymorphism that modulates PON1 gene expression level — the G allel...	Vascular Inflammation & Remodeling	HDL Cholesterol	Moderate
rs5882	CETP I405V	Missense variant that reduces CETP enzyme activity, raising HDL-C and enlargi...	Longevity & Aging	HDL Cholesterol	Moderate
rs4775065	LIPC	Intronic LIPC variant associated with susceptibility to low HDL-C and coronar...	Triglycerides & Fatty Acids	HDL Cholesterol	Moderate
rs4939883	LOC105372112	Intronic variant near LIPG whose T allele increases circulating endothelial l...	Triglycerides & Fatty Acids	HDL Cholesterol	Strong
rs57137919	ABCG1	ABCG1 promoter variant that reduces transporter expression, impairing macroph...	Triglycerides & Fatty Acids	HDL Cholesterol	Moderate
rs692383	ABCG1 ABCG1 HDL-c Variant	Intronic variant in the ABCG1 cholesterol efflux transporter gene associated ...	Triglycerides & Fatty Acids	HDL Cholesterol	Emerging
rs8034802	LIPC	Intronic LIPC variant associated with higher baseline HDL-C and an amplified ...	Triglycerides & Fatty Acids	HDL Cholesterol	Emerging
rs9951026	LIPG	Intronic LIPG variant that tags a haplotype associated with higher LDL choles...	Triglycerides & Fatty Acids	HDL Cholesterol	Moderate
rs6031551	HNF4A HNF4A Regulatory Variant	Intronic variant 80 bp from rs6031552 within the HNF4A P2 promoter haplotype ...	Blood Sugar & Diabetes	HDL Cholesterol	Emerging
rs6031552	HNF4A HNF4A Regulatory Variant	Intronic variant tagging the HNF4A P2 promoter haplotype; carriers have modes...	Blood Sugar & Diabetes	HDL Cholesterol	Moderate