Tag

HPA Axis

13 genetic variants with this tag.

RSID	Gene	Description	Category
rs10482605	NR3C1	NR3C1 promoter variant reducing glucocorticoid receptor transcription; G alle...	Longevity & Aging	HPA Axis	Moderate
rs10515522	NR3C1	Intronic NR3C1 variant associated with longevity in Polish nonagenarians and ...	Longevity & Aging	HPA Axis	Emerging
rs1545843	SLC6A15 SLC6A15 depression risk variant	Intronic variant reducing SLC6A15 expression in hippocampus; AA carriers show...	Mood & Behavior	HPA Axis	Strong
rs12086634	HSD11B1 Intron 3 variant	Modulates local cortisol activation from cortisone in liver and adipose tissu...	Hormones & Sleep	HPA Axis	Moderate
rs258750	NR3C1 NR3C1 Intronic Variant (c.2181+244A>G)	Intronic NR3C1 variant tagging glucocorticoid receptor gene haplotype blocks ...	Reproductive Hormones	HPA Axis	Moderate
rs2522833	PCLO Ser4814Ala	Missense variant in the C2A calcium-binding domain of presynaptic scaffolding...	Mood & Behavior	HPA Axis	Moderate
rs41423247	NR3C1 BclI	Intronic glucocorticoid receptor variant affecting cortisol sensitivity and s...	Mood & Behavior	HPA Axis	Strong
rs2918418	NR3C1	Intronic NR3C1 variant with CC genotype enriched in Polish centenarians; GG g...	Longevity & Aging	HPA Axis	Emerging
rs2963154	NR3C1	Intronic NR3C1 variant with TT genotype enriched in Polish centenarians; C al...	Longevity & Aging	HPA Axis	Emerging
rs7647305	ETV5	GWAS obesity locus near ETV5 — affects hypothalamic appetite regulation and f...	Appetite & Obesity	HPA Axis	Moderate
rs9556979	STK24 HPA Axis Regulation	Regulatory variant near STK24 (MST3), a kinase essential for hippocampal neur...	Mood & Behavior	HPA Axis	Moderate
rs6198	NR3C1 9β	3'UTR variant that increases glucocorticoid-resistant GRβ isoform expression,...	Longevity & Aging	HPA Axis	Strong
rs9470080	FKBP5	Intronic FKBP5 variant in the stress-aging haplotype block — T allele carrier...	Longevity & Aging	HPA Axis	Strong