Tag

Menopause

33 genetic variants with this tag.

RSID	Gene	Description	Category
rs10183486	TLK1	Intronic variant in TLK1 (tousled like kinase 1), a DNA-damage-repair and chr...	Gamete Quality & DNA Repair	Menopause	Strong
rs1046089	PRRC2A Arg1740His	Missense variant in PRRC2A (HLA-B associated transcript) linked to age at nat...	Fertility & Ovarian Function	Menopause	Strong
rs116098458	KIF2B	Rare intronic variant in a lncRNA antisense to KIF2B (chromosome 17q22), iden...	Gamete Quality & DNA Repair	Menopause	Moderate
rs12651246	HELQ HELQ Helicase Meiotic Repair Variant	An intronic variant in HELQ (helicase, POLQ-like) on chromosome 4q21.23; the ...	Gamete Quality & DNA Repair	Menopause	Strong
rs1635501	EXO1 EXO1 rs1635501	Intronic variant in EXO1 (exonuclease 1), a DNA mismatch repair and meiotic r...	Gamete Quality & DNA Repair	Menopause	Strong
rs1172816	BRSK1 BRSK1 Ovarian Reserve Variant	Intronic variant in BRSK1 (BR serine/threonine kinase 1) on chromosome 19q13....	Fertility & Ovarian Function	Menopause	Strong
rs2147349	XPO4	Intronic variant in XPO4 (chromosome 13q12.11) at a locus associated with age...	Gamete Quality & DNA Repair	Menopause	Moderate
rs12206094	FOXO3	Functional FOXO3 intronic variant with allele-specific CTCF binding and IGF-1...	Longevity & Aging	Menopause	Strong
rs2277339	PRIM1 PRIM1 Asp5Ala missense variant	Missense variant in PRIM1 (DNA primase small subunit) that changes aspartate ...	Gamete Quality & DNA Repair	Menopause	Strong
rs12212067	FOXO3	Intronic FOXO3 variant whose minor G allele creates an MZF1 transcription fac...	Longevity & Aging	Menopause	Strong
rs16991615	MCM8 E341K	Missense variant in the MCM8 DNA repair helicase associated with ovarian rese...	Fertility & Ovarian Function	Menopause	Strong
rs2153157	SYCP2L SYCP2L splice-efficiency variant	Intronic SYCP2L variant in a U12-type minor intron; the A allele splices more...	Fertility & Ovarian Function	Menopause	Strong
rs13217795	FOXO3	Original 2008 Willcox longevity discovery variant; C allele tags the protecti...	Longevity & Aging	Menopause	Strong
rs2307449	POLG	Intronic variant in POLG (mitochondrial DNA polymerase gamma) on chromosome 1...	Gamete Quality & DNA Repair	Menopause	Strong
rs236114	MCM8	Intronic variant in MCM8 (minichromosome maintenance 8 helicase) on chromosom...	Gamete Quality & DNA Repair	Menopause	Strong
rs244715	ZNF346	Intronic variant in ZNF346 (chromosome 5q35.2), a proxy SNP for the UIMC1/RAP...	Gamete Quality & DNA Repair	Menopause	Strong
rs353478	UIMC1 UIMC1 DNA Damage Response Variant	An intronic variant in UIMC1 (RAP80), the core ubiquitin-binding subunit of t...	Gamete Quality & DNA Repair	Menopause	Strong
rs2747648	ESR1 ESR1 3′UTR miR-453 site	3'UTR variant in estrogen receptor alpha that alters miR-453 binding affinity...	Reproductive Hormones	Menopause	Moderate
rs2303369	FNDC4	Intronic variant in FNDC4 (fibronectin type III domain containing 4) on chrom...	Fertility & Ovarian Function	Menopause	Strong
rs72755295	EXO1 EXO1 mismatch repair variant	Intronic regulatory variant in EXO1 (exonuclease 1) that increases EXO1 enhan...	Gamete Quality & DNA Repair	Menopause	Moderate
rs28416520	PIWIL1 PIWIL1 piRNA Pathway Variant	A regulatory variant upstream of PIWIL1 on chromosome 12, in a CpG region of ...	Fertility & Ovarian Function	Menopause	Moderate
rs1935949	FOXO3	Second independent FOXO3 longevity signal tagging a distinct intronic haploty...	Longevity & Aging	Menopause	Moderate
rs3750243	EIF4EBP1 EIF4EBP1 mTOR Pathway Variant	Regulatory variant 2 kb upstream of EIF4EBP1 (encoding 4E-BP1, a direct mTOR ...	Fertility & Ovarian Function	Menopause	Strong
rs2153960	FOXO3	Intronic FOXO3 tag SNP whose A allele associates with higher circulating IGF-...	Longevity & Aging	Menopause	Moderate
rs4806660	TMEM150B	Intronic variant in TMEM150B (19q13.42) associated with age at natural menopa...	Endometriosis & Uterine Health	Menopause	Strong
rs2253310	FOXO3	Intronic FOXO3 longevity variant; C allele (minor in East Asians) associated ...	Longevity & Aging	Menopause	Moderate
rs727479	CYP19A1	Intronic eQTL variant in the aromatase gene CYP19A1; the minor C allele is th...	Reproductive Hormones	Menopause	Strong
rs9348724	SYCP2L SYCP2L synaptonemal complex variant	Regulatory variant 2 kb upstream of SYCP2L; each copy of the minor C allele a...	Fertility & Ovarian Function	Menopause	Strong
rs9393800	SYCP2L SYCP2L GWAS hit for age at natural menopause	Intronic variant in SYCP2L on chromosome 6p24.2; the G allele associates with...	Fertility & Ovarian Function	Menopause	Strong
rs2234693	ESR1 PvuII	Estrogen receptor alpha intron variant affecting receptor expression and estr...	Hormones & Sleep	Menopause	Moderate
rs2764264	FOXO3	Intronic FOXO3 variant that disrupts an NKX3 transcription factor binding sit...	Longevity & Aging	Menopause	Strong
rs2802292	FOXO3	Longevity-associated intronic enhancer variant with 1.9-fold increased probab...	Longevity & Aging	Menopause	Established
rs4946935	FOXO3	Functionally validated FOXO3 intronic variant that creates an SRF binding sit...	Longevity & Aging	Menopause	Strong