Tag
Menopause
21 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10183486 | TLK1 | Intronic variant in TLK1 (tousled like kinase 1), a DNA-damage-repair and chr... | Gamete Quality & DNA Repair | Strong | |
| rs1046089 | PRRC2A Arg1740His | Missense variant in PRRC2A (HLA-B associated transcript) linked to age at nat... | Fertility & Ovarian Function | Strong | |
| rs2277339 | PRIM1 PRIM1 Asp5Ala missense variant | Missense variant in PRIM1 (DNA primase small subunit) that changes aspartate ... | Gamete Quality & DNA Repair | Strong | |
| rs16991615 | MCM8 E341K | Missense variant in the MCM8 DNA repair helicase associated with ovarian rese... | Fertility & Ovarian Function | Strong | |
| rs244715 | ZNF346 | Intronic variant in ZNF346 (chromosome 5q35.2), a proxy SNP for the UIMC1/RAP... | Gamete Quality & DNA Repair | Strong | |
| rs12212067 | FOXO3 | Intronic FOXO3 variant whose minor G allele creates an MZF1 transcription fac... | Longevity & Aging | Strong | |
| rs2153157 | SYCP2L SYCP2L splice-efficiency variant | Intronic SYCP2L variant in a U12-type minor intron; the A allele splices more... | Fertility & Ovarian Function | Strong | |
| rs72755295 | EXO1 EXO1 mismatch repair variant | Intronic regulatory variant in EXO1 (exonuclease 1) that increases EXO1 enhan... | Gamete Quality & DNA Repair | Moderate | |
| rs13217795 | FOXO3 | Original 2008 Willcox longevity discovery variant; C allele tags the protecti... | Longevity & Aging | Strong | |
| rs2747648 | ESR1 ESR1 3′UTR miR-453 site | 3'UTR variant in estrogen receptor alpha that alters miR-453 binding affinity... | Reproductive Hormones | Moderate | |
| rs2303369 | FNDC4 | Intronic variant in FNDC4 (fibronectin type III domain containing 4) on chrom... | Fertility & Ovarian Function | Strong | |
| rs1935949 | FOXO3 | Second independent FOXO3 longevity signal tagging a distinct intronic haploty... | Longevity & Aging | Moderate | |
| rs28416520 | PIWIL1 PIWIL1 piRNA Pathway Variant | A regulatory variant upstream of PIWIL1 on chromosome 12, in a CpG region of ... | Fertility & Ovarian Function | Moderate | |
| rs2153960 | FOXO3 | Intronic FOXO3 tag SNP whose A allele associates with higher circulating IGF-... | Longevity & Aging | Moderate | |
| rs4806660 | TMEM150B | Intronic variant in TMEM150B (19q13.42) associated with age at natural menopa... | Endometriosis & Uterine Health | Strong | |
| rs727479 | CYP19A1 | Intronic eQTL variant in the aromatase gene CYP19A1; the minor C allele is th... | Reproductive Hormones | Strong | |
| rs2234693 | ESR1 PvuII | Estrogen receptor alpha intron variant affecting receptor expression and estr... | Hormones & Sleep | Moderate | |
| rs9393800 | SYCP2L SYCP2L GWAS hit for age at natural menopause | Intronic variant in SYCP2L on chromosome 6p24.2; the G allele associates with... | Fertility & Ovarian Function | Strong | |
| rs2764264 | FOXO3 | Intronic FOXO3 variant that disrupts an NKX3 transcription factor binding sit... | Longevity & Aging | Strong | |
| rs2802292 | FOXO3 | Longevity-associated intronic enhancer variant | Longevity & Aging | Established | |
| rs4946935 | FOXO3 | Functionally validated FOXO3 intronic variant that creates an SRF binding sit... | Longevity & Aging | Strong |