Tag
Metabolic Health
42 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10010131 | WFS1 WFS1 Intron 4 T2D Risk Variant | Intronic variant in WFS1 (wolframin) on chromosome 4q22, one of the earliest ... | Blood Sugar & Diabetes | Strong | |
| rs1044471 | ADIPOR2 ADIPOR2 3'UTR variant | A common 3'UTR variant in the liver-expressed adiponectin receptor 2 gene; th... | Fat Storage & Energy | Moderate | |
| rs1058322 | ADIPOR2 | Intronic ADIPOR2 variant whose T allele reduces receptor expression in immune... | Fat Storage & Energy | Moderate | |
| rs1044498 | ENPP1 K121Q | ENPP1 K121Q variant that increases ENPP1 binding affinity to the insulin rece... | Blood Sugar & Diabetes | Strong | |
| rs11061946 | ADIPOR2 | Intronic variant in the adiponectin receptor 2 gene; rare homozygotes showed ... | Fat Storage & Energy | Emerging | |
| rs116862713 | PRKAB1 | Rare AMPK beta-1 subunit variant linking central energy sensing to shared mig... | Fat Storage & Energy | Emerging | |
| rs104894011 | GCK Glu265Lys (MODY2) | Pathogenic glucokinase missense variant causing MODY2 — mild, stable fasting ... | Blood Sugar & Diabetes | Established | |
| rs1175544 | PPARG PPARG rs1175544 | Intronic PPARG variant that accounts for ~7% of individual variation in body ... | Fat Storage & Energy | Emerging | |
| rs12490265 | PPARG PPARG Intronic Haplotype Variant | Intronic PPARG variant in a metabolic syndrome–associated haplotype block; th... | Fat Storage & Energy | Emerging | |
| rs10885406 | TCF7L2 TCF7L2 Wnt Signaling Depth Variant | Intronic TCF7L2 variant tagging the diabetes-risk haplotype and associated wi... | Blood Sugar & Diabetes | Moderate | |
| rs16861194 | ADIPOQ -11426A>G | Upstream promoter variant that reduces ADIPOQ transcription, lowering circula... | Fat Storage & Energy | Moderate | |
| rs16861205 | ADIPOQ | Intronic ADIPOQ variant in LD with the promoter region; the minor A allele is... | Fat Storage & Energy | Moderate | |
| rs2229616 | MC4R V103I | Missense variant in MC4R converting valine to isoleucine at position 103; the... | Appetite & Obesity | Strong | |
| rs563694 | ABCB11 G6PC2/ABCB11 fasting glucose locus | Intronic variant in ABCB11 in strong linkage disequilibrium with G6PC2 regula... | Liver Fat | Strong | |
| rs11558471 | SLC30A8 SLC30A8 Zinc Transport Depth Variant | 3-prime UTR variant in the SLC30A8 zinc transporter gene that alters ZnT8 mRN... | Blood Sugar & Diabetes | Strong | |
| rs16928751 | ADIPOR2 ADIPOR2 CVD co-association variant | Synonymous coding variant in ADIPOR2 (Q265Q) that was co-associated with card... | Fat Storage & Energy | Emerging | |
| rs11708067 | ADCY5 ADCY5 Glucose Signaling Variant | Intronic regulatory variant that reduces ADCY5 expression in pancreatic islet... | Blood Sugar & Diabetes | Strong | |
| rs2361502 | MROH2A | Intronic variant adjacent to the UGT1A gene cluster; C allele tags elevated s... | Metabolic Enzymes & Rare Disorders | Moderate | |
| rs1884614 | HNF4A HNF4A P2 Promoter rs1884614 | Intronic variant tagging the HNF4A P2 promoter risk haplotype; the T allele i... | Hormones & Sleep | Moderate | |
| rs2016105 | ELK3 ELK3 TSH regulatory variant | Intronic regulatory variant in ELK3 influencing circulating TSH levels and hy... | Hormones & Sleep | Strong | |
| rs2959272 | PPARG PPARG intronic calorie-restriction trial variant | Intronic PPARG variant significantly associated with individual variation in ... | Fat Storage & Energy | Emerging | |
| rs1571583 | GLIS3 GLIS3 Beta Cell Development Variant | Intronic GLIS3 variant in which the rare A allele modestly elevates TSH, refl... | Blood Sugar & Diabetes | Strong | |
| rs4784165 | TOX3 TOX3 rs4784165 | Intronic PCOS susceptibility variant near TOX3; the G allele is associated wi... | Fertility & Ovarian Function | Moderate | |
| rs17696736 | NAA25 NAA25 G/A | Intronic tag SNP at the 12q24 locus, increasing risk for type 1 diabetes, juv... | Blood Sugar & Diabetes | Strong | |
| rs2144908 | HNF4A HNF4A P2 Block rs2144908 | Intronic HNF4A P2 promoter haplotype tag variant; carriers have modestly impa... | Hormones & Sleep | Moderate | |
| rs3856806 | PPARG His477His (C1431T) | Synonymous PPARG variant where the T allele reduces type 2 diabetes risk and ... | Fat Storage & Energy | Strong | |
| rs822391 | ADIPOQ IVS1+407C>T | Intronic variant in the adiponectin gene associated with ischemic stroke risk... | Fat Storage & Energy | Moderate | |
| rs2229431 | INSR | Synonymous exon 13 variant in the insulin receptor gene; the A allele has bee... | Blood Sugar & Diabetes | Emerging | |
| rs2268574 | GCK c.679+38T>G | Intronic GCK variant 38 bp downstream of exon 7; the A allele (GRCh38 referen... | Blood Sugar & Diabetes | Emerging | |
| rs2466293 | SLC30A8 SLC30A8 Islet Zinc Regulation Variant | 3'UTR variant in the zinc transporter ZnT8 gene that disrupts miRNA binding s... | Blood Sugar & Diabetes | Moderate | |
| rs3787345 | PTPN1 PTPN1 LD Block Co-Variant | Intronic PTPN1 tag SNP within the 100-kb PTP1B insulin-resistance haplotype b... | Blood Sugar & Diabetes | Moderate | |
| rs3787348 | PTPN1 PTPN1 intronic variant | Intronic PTPN1 tag SNP within the 100-kb insulin-resistance haplotype block; ... | Blood Sugar & Diabetes | Moderate | |
| rs397514580 | GCK GCK MODY2 E339K | Pathogenic glucokinase missense variant causing maturity-onset diabetes of th... | Blood Sugar & Diabetes | Strong | |
| rs4607517 | GCK GCK fasting glucose GWAS variant | Common variant near glucokinase that raises fasting glucose by impairing the ... | Blood Sugar & Diabetes | Strong | |
| rs4807015 | PTPRS PTPRS T2D risk variant | Intronic PTPRS variant that tags elevated type 2 diabetes risk in both sexes ... | Blood Sugar & Diabetes | Moderate | |
| rs4812829 | HNF4A HNF4A Intronic T2D Risk Variant | Common intronic variant in HNF4A associated with modestly elevated type 2 dia... | Blood Sugar & Diabetes | Strong | |
| rs743572 | CYP17A1 -34 T>C | Promoter variant affecting 17α-hydroxylase expression and steroid hormone syn... | Hormones & Sleep | Strong | |
| rs7850258 | PTCSC2 | Intronic variant in the PTCSC2 lncRNA that alters a FOXE1 enhancer element, m... | Hormones & Sleep | Strong | |
| rs965513 | FOXE1 | Strongest GWAS thyroid locus — regulatory variant near FOXE1 affecting thyroi... | Hormones & Sleep | Strong | |
| rs6020611 | PTPN1 | Intronic PTPN1 tag SNP in the PTP1B regulatory LD block; the minor A allele i... | Blood Sugar & Diabetes | Moderate | |
| rs6067484 | PTPN1 PTPN1 rs6067484 | Intronic PTPN1 tag SNP raising LDL cholesterol risk in lean individuals | Blood Sugar & Diabetes | Moderate | |
| rs7202877 | CTRB1 | Intergenic variant near CTRB1/CTRB2 that regulates chymotrypsinogen expressio... | Blood Sugar & Diabetes | Strong |