Tag

Mood

33 genetic variants with this tag.

RSID	Gene	Description	Category
rs1006737	CACNA1C	L-type calcium channel gene variant affecting mood regulation, emotional proc...	Mood & Behavior	Mood	Strong
rs10462020	PER3 V647G	Missense variant in circadian clock gene PER3 associated with morning chronot...	Hormones & Sleep	Mood	Moderate
rs10514299	TMEM161B-MEF2C TMEM161B-MEF2C intergenic variant	Intronic variant near the MEF2C transcription factor locus associated with in...	Mood & Behavior	Mood	Strong
rs10786831	SORCS3 SORCS3 Depression Variant	Intronic variant in the neurotrophin sorting receptor SORCS3, the top GWAS hi...	Mood & Behavior	Mood	Strong
rs11599236	SORCS3 SORCS3 Neurotrophin Sorting	Intronic variant in the BDNF-receptor trafficking gene SORCS3, associated wit...	Mood & Behavior	Mood	Strong
rs12624433	SLC12A5 KCC2 Chloride Transport	Intronic variant in SLC12A5 reducing KCC2 potassium-chloride cotransporter fu...	Mood & Behavior	Mood	Moderate
rs1369481	NPAS2	Intronic variant in the brain-specific circadian transcription factor NPAS2; ...	Hormones & Sleep	Mood	Emerging
rs139315125	PER3 H417R	Rare PER3 missense variant that co-occurs on the FASPS3 haplotype with Pro415...	Hormones & Sleep	Mood	Strong
rs1800883	HTR5A	Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting recep...	Mood & Behavior	Mood	Moderate
rs150812083	PER3 PER3 Pro415Ala (FASPS3)	Rare PER3 missense variant that destabilizes the circadian clock protein, sho...	Hormones & Sleep	Mood	Strong
rs2271933	HCRTR1 Ile408Val	Missense variant in the orexin/hypocretin receptor 1 that alters G-protein si...	Mood & Behavior	Mood	Moderate
rs2371365	PCLO PCLO Presynaptic Scaffold	Intronic variant in the presynaptic scaffold gene PCLO linked to altered mono...	Mood & Behavior	Mood	Moderate
rs2522833	PCLO Ser4814Ala	Missense variant in the C2A calcium-binding domain of presynaptic scaffolding...	Mood & Behavior	Mood	Moderate
rs25531	SLC6A4 A>G	Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and...	Mood & Behavior	Mood	Moderate
rs2568958	NEGR1 NEGR1 depression/BMI variant	Intergenic tag SNP near NEGR1 associated with elevated BMI and major depressi...	Mood & Behavior	Mood	Strong
rs34579341	NEGR1 NEGR1 Neuronal Growth Regulator	Intronic tag SNP in NEGR1 affecting neuronal cell adhesion, hippocampal neuro...	Mood & Behavior	Mood	Strong
rs35936514	LHPP LHPP depression risk variant	Intronic/3'UTR variant in LHPP, a histidine phosphatase essential for stress ...	Mood & Behavior	Mood	Strong
rs2050122	HTR6	Regulatory variant near the HTR6 serotonin 6 receptor gene associated with ch...	Hormones & Sleep	Mood	Moderate
rs4395923	CYP7B1 CYP7B1 Neurosteroid Hydroxylase	Intronic variant in the brain neurosteroid hydroxylase gene affecting DHEA an...	Mood & Behavior	Mood	Emerging
rs4702	FURIN proBDNF Processing Variant	A 3'UTR regulatory variant where the G allele creates a miR-338-3p binding si...	Mood & Behavior	Mood	Moderate
rs225014	DIO2 Thr92Ala	Affects conversion of inactive T4 to active T3 thyroid hormone in brain, pitu...	Hormones & Sleep	Mood	Strong
rs6295	HTR1A C-1019G	Functional promoter variant in the serotonin 1A receptor gene that increases ...	Mood & Behavior	Mood	Strong
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Mood	Strong
rs6323	MAOA R297R	X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans...	Mood & Behavior	Mood	Strong
rs72704544	GPM6A GPM6A Neuronal Membrane Glycoprotein	Intronic variant in the neuronal membrane glycoprotein M6a gene — a stress-do...	Mood & Behavior	Mood	Moderate
rs2675703	OPN4	Missense variant (Pro10Leu) in melanopsin, the photopigment driving circadian...	Hormones & Sleep	Mood	Emerging
rs73034295	IGSF9B IGSF9B Inhibitory Synapse Adhesion	Intronic variant in the gene encoding the inhibitory synaptic adhesion protei...	Mood & Behavior	Mood	Emerging
rs208294	P2RX7 His155Tyr	Gain-of-function missense variant in the P2X7 ATP-gated receptor that increas...	Neurology & Cognition	Mood	Moderate
rs2230912	P2RX7 Gln460Arg	Missense variant in the C-terminal domain of the P2X7 receptor that disrupts ...	Neurology & Cognition	Mood	Moderate
rs9556979	STK24 HPA Axis Regulation	Regulatory variant near STK24 (MST3), a kinase essential for hippocampal neur...	Mood & Behavior	Mood	Moderate
rs956572	BCL2	Intronic variant in the anti-apoptotic gene BCL2 that affects BCL2 expression...	Mood & Behavior	Mood	Moderate
rs4746	GLO1 Glu111Ala	Missense variant in glyoxalase 1 reducing enzyme activity, allowing methylgly...	Hormones & Sleep	Mood	Moderate
rs4680	COMT Val158Met	Dopamine/catecholamine breakdown — affects stress response and methyl donor t...	Methylation & Detox	Mood	Established