Tag

Neuroinflammation

36 genetic variants with this tag.

RSID	Gene	Description	Category
rs1016140	CD58	Intronic CD58 variant with a dual role — the G allele increases T-cell activi...	Neurology & Cognition	Neuroinflammation	Moderate
rs10984447	DBC1 DBC1 multiple sclerosis susceptibility variant	Intronic variant in DBC1 (DBCCR1/BRINP1) at 9q33.1 associated with multiple s...	TNF, NF-kB & Inflammatory Cytokines	Neuroinflammation	Moderate
rs10456100	KCNK5	Intronic variant near KCNK5 that reduces TASK2 potassium channel expression a...	Neurology & Cognition	Neuroinflammation	Strong
rs142885915	NPSR1 NPSR1 Endometriosis Risk Variant	An intronic insertion/deletion variant in the neuropeptide S receptor 1 gene ...	Endometriosis & Uterine Health	Neuroinflammation	Moderate
rs12044852	CD58	Intronic CD58 variant in strong LD with rs2300747 (r²=0.929); the C allele dr...	Neurology & Cognition	Neuroinflammation	Strong
rs12053868	IL1RAP IL1RAP amyloid risk variant	Intronic variant in IL1RAP that impairs microglial activation, accelerating b...	Neurology & Cognition	Neuroinflammation	Moderate
rs12459419	CD33 CD33 exon 2 splicing variant	Coding variant in CD33 (Siglec-3) that alters exon 2 splicing in microglia — ...	Neurology & Cognition	Neuroinflammation	Strong
rs17493811	AGER	Tag SNP in the AGER 3′ downstream region associated with increased type 1 dia...	Hormones & Sleep	Neuroinflammation	Moderate
rs12693542	SLC40A1	Regulatory variant upstream of ferroportin (the sole cellular iron exporter) ...	Neurology & Cognition	Neuroinflammation	Strong
rs199347	GPNMB	Intronic GPNMB variant that acts as a brain eQTL; the A allele increases GPNM...	Longevity & Aging	Neuroinflammation	Strong
rs1335532	CD58	Intronic CD58 variant that sits inside the miR-548ac stem-loop; the A allele ...	Neurology & Cognition	Neuroinflammation	Strong
rs2069837	IL6	Intronic IL6 enhancer variant that regulates the anti-inflammatory gene GPNMB...	Longevity & Aging	Neuroinflammation	Moderate
rs1414273	CD58	Intronic CD58 variant hosting the miR-548ac stem-loop; the C allele creates a...	Neurology & Cognition	Neuroinflammation	Strong
rs1532278	CLU CLU Alzheimer's risk variant	Intronic regulatory variant in CLU (clusterin/apolipoprotein J) that controls...	Neurology & Cognition	Neuroinflammation	Strong
rs1718119	P2RX7 Ala348Thr	Gain-of-function variant in the P2X7 receptor that increases ATP-gated pore f...	Neurology & Cognition	Neuroinflammation	Moderate
rs2070600	AGER Gly82Ser	Missense variant in the AGER pattern-recognition receptor that reduces solubl...	Hormones & Sleep	Neuroinflammation	Strong
rs1800693	TNFRSF1A	Splice-region variant in TNFR1 that generates a soluble Δ6 isoform mimicking ...	Neurology & Cognition	Neuroinflammation	Strong
rs2078371	TSPAN2	Regulatory variant in the TSPAN2/NGF locus on chromosome 1p13; the C allele i...	Neurology & Cognition	Neuroinflammation	Strong
rs208294	P2RX7 His155Tyr	Gain-of-function missense variant in the P2X7 ATP-gated receptor that increas...	Neurology & Cognition	Neuroinflammation	Moderate
rs28362944	SERPING1	5' UTR variant in C1-inhibitor gene that promotes partial exon 2 skipping, re...	Hormones & Sleep	Neuroinflammation	Moderate
rs2230912	P2RX7 Gln460Arg	Missense variant in the C-terminal domain of the P2X7 receptor that disrupts ...	Neurology & Cognition	Neuroinflammation	Moderate
rs2300747	CD58	Intronic variant in CD58 (LFA-3) that modulates T-cell costimulation and Treg...	Neurology & Cognition	Neuroinflammation	Strong
rs3816183	HAAO Ile37Val	Missense variant in the kynurenine pathway enzyme HAAO that shifts tryptophan...	Hormones & Sleep	Neuroinflammation	Moderate
rs3129934	HLA-DRB5 DR15 haplotype tag	Tag SNP for HLA-DRB5*01:01 on the DR15 susceptibility haplotype, physically n...	Neurology & Cognition	Neuroinflammation	Strong
rs3135388	HLA-DRA Tag for DRB1*15:01	Tag SNP for HLA-DRB1*15:01 (physically located near HLA-DRA), the strongest g...	Neurology & Cognition	Neuroinflammation	Established
rs4926	SERPING1 Val480Met	Missense variant in C1-inhibitor gene associated with insomnia risk through n...	Hormones & Sleep	Neuroinflammation	Moderate
rs3751143	P2RX7 Glu496Ala	Loss-of-function variant in the P2X7 receptor that reduces inflammatory respo...	Neurology & Cognition	Neuroinflammation	Strong
rs3865444	CD33 CD33 microglial Alzheimer's variant	Promoter-region variant that modulates CD33 expression on microglia — the pro...	Neurology & Cognition	Neuroinflammation	Strong
rs4149584	TNFRSF1A R92Q	Missense variant in TNF receptor 1 that causes low-penetrance TRAPS (recurren...	Neurology & Cognition	Neuroinflammation	Strong
rs6656401	CR1 CR1 complement receptor Alzheimer's variant	Intronic variant in the complement receptor 1 gene; the minor A allele impair...	Neurology & Cognition	Neuroinflammation	Strong
rs75932628	TREM2 R47H	Rare missense variant in microglial receptor TREM2 that significantly increas...	Neurology & Cognition	Neuroinflammation	Established
rs76904798	LRRK2 5' Regulatory Variant	Common noncoding variant upstream of LRRK2 that increases gene expression in ...	Neurology & Cognition	Neuroinflammation	Strong
rs78117248	ABCA7 ABCA7 AD risk variant	Intronic ABCA7 variant tagging an expanded VNTR that disrupts amyloid-beta cl...	Neurology & Cognition	Neuroinflammation	Strong
rs7958311	P2RX7 Arg270His	P2RX7 variant with a unique dual mechanism — gain-of-function in channel open...	Neurology & Cognition	Neuroinflammation	Moderate
rs9271366	HLA-DQA1 eQTL	Intergenic eQTL near HLA-DQA1 that tags the DR15 haplotype (DRB115:01/DQA10...	Neurology & Cognition	Neuroinflammation	Established
rs9275328	HLA-DQB1 DQB1 region	Intergenic SNP between HLA-DQB1 and HLA-DQA2 that tags the DQB1*06:02 allele,...	Neurology & Cognition	Neuroinflammation	Strong