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rs10767664
|
BDNF
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Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...
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Appetite & Obesity
|
|
Strong
|
|
rs1137101
|
LEPR
Q223R (Gln223Arg)
|
Common leptin receptor variant in the leptin-binding domain affecting satiety...
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Hormones & Sleep
|
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Moderate
|
|
rs11152221
|
MC4R
MC4R Proximal LD Block Variant
|
Intergenic variant in the proximal 3' regulatory block near MC4R associated w...
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Appetite & Obesity
|
|
Strong
|
|
rs1943226
|
MC4R
MC4R third tagSNP
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Upstream regulatory tag variant ~3 kb proximal to MC4R, included in MC4R hapl...
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Appetite & Obesity
|
|
Emerging
|
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rs2922126
|
GHSR
GHSR A/G (rs2922126)
|
Upstream regulatory variant near the ghrelin receptor gene; the A allele is a...
|
Appetite & Obesity
|
|
Moderate
|
|
rs476828
|
MC4R
MC4R-region BMI variant
|
Intergenic variant in the MC4R regulatory haplotype block, tagging the same a...
|
Appetite & Obesity
|
|
Strong
|
|
rs489693
|
MC4R
MC4R AIWG variant
|
Intergenic variant near MC4R with genome-wide significant association with an...
|
Appetite & Obesity
|
|
Strong
|
|
rs490683
|
GHSR
GHSR Promoter NF-1 Site Variant
|
Promoter variant in the ghrelin receptor gene that disrupts NF-1 transcriptio...
|
Appetite & Obesity
|
|
Moderate
|
|
rs571312
|
MC4R
MC4R Regulatory Variant (Appetite Signaling)
|
Regulatory variant upstream of MC4R associated with increased caloric intake,...
|
Appetite & Obesity
|
|
Strong
|
|
rs6232
|
PCSK1
PCSK1 N221D (Asn221Asp)
|
Missense variant in PCSK1 encoding an Asn221Asp substitution near the Ca-1 ca...
|
Appetite & Obesity
|
|
Strong
|
|
rs6234
|
PCSK1
PCSK1 Q665E (Gln665Glu)
|
Missense variant in PCSK1 that causes a Gln665Glu substitution in the C-termi...
|
Appetite & Obesity
|
|
Strong
|
|
rs696217
|
GHRL
Leu72Met
|
Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...
|
Appetite & Obesity
|
|
Moderate
|
|
rs7799039
|
LEP
G-2548A
|
Promoter variant that increases leptin gene expression in adipose tissue, ele...
|
Appetite & Obesity
|
|
Moderate
|
|
rs3211867
|
CD36
|
Intronic CD36 variant that reduces CD36 expression, impairing postprandial fa...
|
Triglycerides & Fatty Acids
|
|
Moderate
|
|
rs9819506
|
GHSR
GHSR Promoter Variant (Ghrelin Receptor Signaling)
|
Promoter-region tag SNP in the ghrelin receptor gene associated with body wei...
|
Appetite & Obesity
|
|
Moderate
|
|
rs5085
|
APOA2
APOA2 rs5085
|
Intronic APOA2 tag SNP that captures the saturated fat-weight gain interactio...
|
Triglycerides & Fatty Acids
|
|
Strong
|