Tag

Appetite

14 genetic variants with this tag.

RSID	Gene	Description	Category
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Nutrition & Metabolism	Obesity Metabolic Diabetes	Established
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Nutrition & Metabolism	Appetite Obesity Metabolic	Strong
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant affecting satiety signaling and metabolic health	Nutrition & Metabolism	Nutrition & Metabolism Obesity Diabetes	Moderate
rs16147	NPY C-399T	Promoter variant in neuropeptide Y that modulates NPY expression under stress...	Brain & Mental Health	Stress Response Appetite Obesity	Moderate
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Nutrition & Metabolism	Obesity Appetite Diet	Moderate
rs696217	GHRL Leu72Met	Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...	Nutrition & Metabolism	Obesity Appetite Metabolic Syndrome	Moderate
rs6548238	TMEM18	Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...	Nutrition & Metabolism	Obesity Appetite Fat Metabolism	Strong
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Nutrition & Metabolism	Obesity Appetite Diet	Strong
rs11172113	LRP1	Intronic enhancer variant in LRP1 that regulates receptor expression in brain...	Nutrition & Metabolism	Leptin Cardiovascular Brain Health	Moderate
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Nutrition & Metabolism	Obesity Appetite Diabetes	Moderate
rs29941	KCTD15	GWAS obesity locus near KCTD15 — modulates adipogenesis through AP-2 transcri...	Nutrition & Metabolism	Obesity Fat Metabolism Adipogenesis	Moderate
rs7647305	ETV5	GWAS obesity locus near ETV5 — affects hypothalamic appetite regulation and f...	Nutrition & Metabolism	Obesity Appetite Dopamine	Moderate
rs10767664	BDNF	Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...	Nutrition & Metabolism	Obesity Satiety Appetite	Strong
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Nutrition & Metabolism	Obesity Appetite Neurotransmitters	Strong