Tag

Appetite

43 genetic variants with this tag.

RSID	Gene	Description	Category
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Appetite & Obesity	Appetite	Strong
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Appetite & Obesity	Appetite	Moderate
rs10515237	PCSK1 PCSK1 A/G (rs10515237)	Intronic variant in PCSK1 that tags the Q665E-S690T functional haplotype, red...	Appetite & Obesity	Appetite	Moderate
rs1059369	GDF15 S48T	GDF15 signal-peptide missense variant that tags a haplotype influencing circu...	Fat Storage & Energy	Appetite	Moderate
rs10766383	NUCB2	Intronic NUCB2 variant associated with type 2 diabetes risk in females and or...	Hormones & Sleep	Appetite	Moderate
rs10767664	BDNF	Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...	Appetite & Obesity	Appetite	Strong
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant in the leptin-binding domain affecting satiety...	Hormones & Sleep	Appetite	Moderate
rs11152221	MC4R MC4R Proximal LD Block Variant	Intergenic variant in the proximal 3' regulatory block near MC4R associated w...	Appetite & Obesity	Appetite	Strong
rs11172113	LRP1	Intronic enhancer variant in LRP1 that regulates receptor expression in brain...	Fat Storage & Energy	Appetite	Moderate
rs11644943	FTO FTO Mid-Gene Intron Variant	An intronic FTO variant outside the well-known intron-1 obesity cluster; the ...	Appetite & Obesity	Appetite	Emerging
rs12970134	MC4R MC4R region variant	Near-gene variant ~188kb downstream of MC4R associated with increased waist c...	Appetite & Obesity	Appetite	Strong
rs13407913	ADCY3	Intronic variant in the adenylyl cyclase 3 gene, which encodes a cAMP-produci...	Fitness & Body	Appetite	Emerging
rs16147	NPY C-399T	Promoter variant in neuropeptide Y that modulates NPY expression under stress...	Mood & Behavior	Appetite	Moderate
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Appetite & Obesity	Appetite	Strong
rs1330	NUCB2	Intronic NUCB2 variant associated with obesity risk in males, type 2 diabetes...	Hormones & Sleep	Appetite	Moderate
rs1800544	ADRA2A ADRA2A Promoter -1291C>G	Promoter variant that alters alpha-2A adrenergic receptor expression, affecti...	Appetite & Obesity	Appetite	Moderate
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Appetite & Obesity	Appetite	Moderate
rs17219084	FTO	FTO intron variant in the extended obesity-associated region, with explorator...	Fitness & Body	Appetite	Emerging
rs1943226	MC4R MC4R third tagSNP	Upstream regulatory tag variant ~3 kb proximal to MC4R, included in MC4R hapl...	Appetite & Obesity	Appetite	Emerging
rs2229616	MC4R V103I	Missense variant in MC4R converting valine to isoleucine at position 103; the...	Appetite & Obesity	Appetite	Strong
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Appetite & Obesity	Appetite	Strong
rs2867125	TMEM18 TMEM18 regulatory variant (2p25.3)	Regulatory variant at the TMEM18 locus on chromosome 2p25.3 — one of the most...	Appetite & Obesity	Appetite	Strong
rs2922126	GHSR GHSR A/G (rs2922126)	Upstream regulatory variant near the ghrelin receptor gene; the A allele is a...	Appetite & Obesity	Appetite	Moderate
rs29941	KCTD15	GWAS obesity locus near KCTD15 — modulates adipogenesis through AP-2 transcri...	Appetite & Obesity	Appetite	Moderate
rs2568958	NEGR1 NEGR1 depression/BMI variant	Intergenic tag SNP near NEGR1 associated with elevated BMI and major depressi...	Mood & Behavior	Appetite	Strong
rs476828	MC4R MC4R-region BMI variant	Intergenic variant in the MC4R regulatory haplotype block, tagging the same a...	Appetite & Obesity	Appetite	Strong
rs4788102	SH2B1 SH2B1/APOBR locus variant	Intronic variant at the SH2B1 locus on chromosome 16p11.2 — a key adaptor pro...	Appetite & Obesity	Appetite	Strong
rs489693	MC4R MC4R AIWG variant	Intergenic variant near MC4R with genome-wide significant association with an...	Appetite & Obesity	Appetite	Strong
rs34579341	NEGR1 NEGR1 Neuronal Growth Regulator	Intronic tag SNP in NEGR1 affecting neuronal cell adhesion, hippocampal neuro...	Mood & Behavior	Appetite	Strong
rs490683	GHSR GHSR Promoter NF-1 Site Variant	Promoter variant in the ghrelin receptor gene that disrupts NF-1 transcriptio...	Appetite & Obesity	Appetite	Moderate
rs509035	GHSR GHSR Metabolic Syndrome Variant	Intronic variant in the ghrelin receptor gene; the A allele is associated wit...	Appetite & Obesity	Appetite	Strong
rs571312	MC4R MC4R Regulatory Variant (Appetite Signaling)	Regulatory variant upstream of MC4R associated with increased caloric intake,...	Appetite & Obesity	Appetite	Strong
rs6232	PCSK1 PCSK1 N221D (Asn221Asp)	Missense variant in PCSK1 encoding an Asn221Asp substitution near the Ca-1 ca...	Appetite & Obesity	Appetite	Strong
rs6234	PCSK1 PCSK1 Q665E (Gln665Glu)	Missense variant in PCSK1 that causes a Gln665Glu substitution in the C-termi...	Appetite & Obesity	Appetite	Strong
rs6235	PCSK1 PCSK1 S690T (Ser690Thr)	Missense variant encoding the Ser690Thr substitution in the C-terminal domain...	Appetite & Obesity	Appetite	Strong
rs6548238	TMEM18	Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...	Appetite & Obesity	Appetite	Strong
rs696217	GHRL Leu72Met	Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...	Appetite & Obesity	Appetite	Moderate
rs7647305	ETV5	GWAS obesity locus near ETV5 — affects hypothalamic appetite regulation and f...	Appetite & Obesity	Appetite	Moderate
rs8087522	MC4R MC4R A/G (rs8087522)	Upstream regulatory variant near MC4R that may create a transcription factor ...	Appetite & Obesity	Appetite	Emerging
rs9819506	GHSR GHSR Promoter Variant (Ghrelin Receptor Signaling)	Promoter-region tag SNP in the ghrelin receptor gene associated with body wei...	Appetite & Obesity	Appetite	Moderate
rs3212018	CD36	A 16-bp deletion in the 3' untranslated region of CD36 that may reduce mRNA s...	Triglycerides & Fatty Acids	Appetite	Emerging
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Appetite & Obesity	Appetite	Established
rs757081	NUCB2 Gln338Glu (Q338E)	Missense variant in nucleobindin-2, the precursor protein cleaved to produce ...	Hormones & Sleep	Appetite	Moderate