Tag

Autoimmune

7 genetic variants with this tag.

RSID	Gene	Description	Category
rs4986790	TLR4 Asp299Gly	Missense variant in Toll-like receptor 4 reducing bacterial endotoxin recogni...	Immune & Gut	Immune System Inflammation Autoimmune	Strong
rs1800896	IL10 -1082 A>G	Promoter variant affecting IL-10 production — the master anti-inflammatory cy...	Immune & Gut	Immune & Autoimmune Inflammation Autoimmune	Strong
rs2476601	PTPN22 R620W	The strongest non-HLA autoimmune risk allele, affecting T-cell and B-cell sig...	Immune & Gut	Autoimmune Immune System Rheumatoid Arthritis	Established
rs1205	CRP +1846C>T	3' UTR variant that modulates baseline C-reactive protein levels and inflamma...	Heart & Inflammation	Inflammation Cardiovascular Diabetes	Strong
rs11209026	IL23R R381Q	Strongly protective variant against inflammatory bowel disease and other auto...	Immune & Gut	Inflammation Autoimmune Immune System	Established
rs3197999	MST1 R689C	Macrophage-stimulating protein variant affecting innate immune response and I...	Immune & Gut	Immune & Gut IBD Innate Immunity	Strong
rs116855232	NUDT15 Arg139Cys	Nucleotide diphosphatase that inactivates toxic thiopurine metabolites; reduc...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Chemotherapy	Established