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rs1801133
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MTHFR
C677T
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Key enzyme for converting folate to its active methylfolate form
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Methylation & Detox
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Established
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rs1801131
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MTHFR
A1298C
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Second MTHFR variant affecting enzyme activity in the regulatory domain
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Methylation & Detox
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Moderate
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rs1051266
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SLC19A1
G80A (His27Arg)
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Folate transporter — how well folate gets into your cells
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Methylation & Detox
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Moderate
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rs2236225
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MTHFD1
G1958A
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Folate processing enzyme — reduced stability increases choline need
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Methylation & Detox
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Strong
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rs1801394
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MTRR
A66G
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B12 recycling enzyme — regenerates active B12 for the methylation cycle
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Methylation & Detox
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Moderate
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rs1805087
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MTR
A2756G
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Methionine synthase — uses B12 to convert homocysteine to methionine
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Methylation & Detox
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Moderate
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rs1544410
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VDR
BsmI
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Vitamin D receptor — affects how well vitamin D activates cellular processes
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Methylation & Detox
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Moderate
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rs10741657
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CYP2R1
promoter variant
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Vitamin D activation — converts D3 to 25(OH)D in the liver
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Methylation & Detox
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Strong
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rs7946
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PEMT
Val175Met
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Phosphatidylcholine production — affects dietary choline requirements
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Methylation & Detox
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Strong
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rs234706
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CBS
C699T
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Common synonymous variant in the CBS gene associated with reduced cardiovascu...
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Methylation & Detox
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Moderate
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rs1801181
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CBS
A360A
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A synonymous variant in CBS affecting homocysteine metabolism and associated ...
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Methylation & Detox
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Moderate
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rs6323
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MAOA
R297R
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X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans...
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Brain & Mental Health
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Strong
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rs567754
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BHMT
BHMT-02
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Intronic variant in betaine-homocysteine methyltransferase gene associated wi...
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Methylation & Detox
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Moderate
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rs1979277
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SHMT1
C1420T
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Alters one-carbon metabolism and folate distribution; influences cancer risk,...
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Methylation & Detox
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Moderate
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rs601338
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FUT2
W143X (Trp143Ter)
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Determines secretor status — whether ABO blood group antigens are secreted in...
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Nutrition & Metabolism
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Established
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rs819147
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AHCY
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Regulatory variant affecting S-adenosylhomocysteine hydrolase expression, inf...
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Methylation & Detox
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Moderate
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rs1801198
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TCN2
Pro259Arg (C776G)
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Transcobalamin II variant affecting cellular delivery of vitamin B12 via holo...
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Nutrition & Metabolism
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Strong
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rs2651899
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PRDM16
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Intronic variant in the master regulator of brown/beige fat differentiation, ...
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Nutrition & Metabolism
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Moderate
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rs602662
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FUT2
Gly258Ser
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Missense variant in the FUT2 fucosyltransferase enzyme that alters haptocorri...
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Nutrition & Metabolism
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Strong
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rs4654748
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NBPF3
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Tag SNP in the NBPF3/ALPL locus on chromosome 1 — the strongest common geneti...
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Nutrition & Metabolism
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Strong
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rs1256335
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ALPL
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Intronic variant near ALPL associated with increased alkaline phosphatase act...
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Nutrition & Metabolism
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Strong
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rs61735836
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FTCD
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Missense variant in the FTCD enzyme that impairs one-carbon unit transfer fro...
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Nutrition & Metabolism
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Strong
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rs234709
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CBS
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Intronic CBS variant that tags the CBS locus in GWAS studies; associated with...
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Nutrition & Metabolism
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Moderate
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rs3760775
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FUT6
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Near-gene regulatory variant near FUT6 that reduces fucosyltransferase expres...
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Nutrition & Metabolism
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Moderate
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rs78060698
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FUT6
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Intronic regulatory variant in FUT6 that alters HNF4α binding and fucosyltran...
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Nutrition & Metabolism
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Moderate
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rs12272669
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UNKNOWN
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Intergenic variant on chromosome 11q13.4 associated with circulating vitamin ...
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Nutrition & Metabolism
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Emerging
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