Tag

Carcinogen Metabolism

16 genetic variants with this tag.

RSID	Gene	Description	Category
rs1229984	ADH1B His48Arg	ADH1B variant encoding a ~100x faster alcohol dehydrogenase enzyme, causing r...	Mood & Behavior	Carcinogen Metabolism	Established
rs1693482	ADH1C Arg272Gln (ADH1C1/2)	ADH1C variant defining the fast (ADH1C1, Arg272) vs slow (ADH1C2, Gln272) a...	Mood & Behavior	Carcinogen Metabolism	Strong
rs2470890	CYP1A2 Asn516= (exon 7)	Synonymous variant in CYP1A2 exon 7 in linkage disequilibrium with the *1F hi...	Cancer Risk	Carcinogen Metabolism	Strong
rs28936700	CYP1B1 Gly61Glu (G61E)	Pathogenic missense variant in the cytochrome P450 1B1 enzyme that abolishes ...	Vascular Inflammation & Remodeling	Carcinogen Metabolism	Established
rs2031920	CYP2E1 *5B (RsaI)	Promoter variant increasing CYP2E1 inducibility, elevating oxidative stress f...	Pharmacogenomics	Carcinogen Metabolism	Moderate
rs2070672	CYP2E1	CYP2E1 promoter variant affecting enzyme expression and susceptibility to ace...	Pharmacogenomics	Carcinogen Metabolism	Moderate
rs28399433	CYP2A6 *9 (TATA box)	Promoter variant that reduces CYP2A6 expression by ~50%, slowing nicotine met...	Pharmacogenomics	Carcinogen Metabolism	Strong
rs366631	GSTM1 Tag SNP for gene deletion	Tag SNP proxy for GSTM1 gene deletion status — the most common pharmacogenomi...	Methylation & Detox	Carcinogen Metabolism	Strong
rs4646976	CYP2E1	CYP2E1 intronic haplotype tag — affects enzyme activity and susceptibility to...	Pharmacogenomics	Carcinogen Metabolism	Moderate
rs71748309	GSTT1 Null (Gene Deletion)	Complete deletion of the GSTT1 gene eliminating glutathione conjugation capac...	Methylation & Detox	Carcinogen Metabolism	Strong
rs55897648	CYP2E1 *3 (Val389Ile)	CYP2E1*3 missense variant with no demonstrated change in enzyme activity for ...	Pharmacogenomics	Carcinogen Metabolism	Emerging
rs6413419	CYP2E1 *4 (V179I)	Missense variant (Val179Ile) defining the CYP2E1*4 allele; associated with al...	Pharmacogenomics	Carcinogen Metabolism	Emerging
rs72547515	CYP1A2 *16 (Arg377Gln)	Nearly-inactive CYP1A2 missense variant — carriers have severely impaired met...	Pharmacogenomics	Carcinogen Metabolism	Moderate
rs72547516	CYP1A2 Ile386Val	Rare CYP1A2 missense variant (Ile386Val) associated with potentially reduced ...	Pharmacogenomics	Carcinogen Metabolism	Emerging
rs72547517	CYP1A2 *8	CYP1A2*8 — near-complete loss-of-function missense variant causing severely r...	Pharmacogenomics	Carcinogen Metabolism	Strong
rs8192780	CYP2E1	Downstream regulatory variant near CYP2E1 associated with nasopharyngeal carc...	Pharmacogenomics	Carcinogen Metabolism	Emerging