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rs10455872
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LPA
|
Intronic variant strongly associated with elevated lipoprotein(a) levels and ...
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Heart & Inflammation
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|
Established
|
|
rs11591147
|
PCSK9
R46L
|
Loss-of-function variant that naturally lowers LDL cholesterol by 15-28% and ...
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Heart & Inflammation
|
|
Established
|
|
rs429358
|
APOE
E4 determinant
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Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high sat...
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Nutrition & Metabolism
|
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Established
|
|
rs708272
|
CETP
TaqIB
|
Influences HDL cholesterol levels and particle size through effects on choles...
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Heart & Inflammation
|
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Strong
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rs693
|
APOB
XbaI (C/T)
|
Silent variant affecting LDL particle number and lipid metabolism; T allele c...
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Heart & Inflammation
|
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Strong
|
|
rs7412
|
APOE
E2 determinant
|
APOE E2 variant - generally protective for cardiovascular health
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Nutrition & Metabolism
|
|
Established
|
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rs662
|
PON1
Q192R
|
Affects paraoxonase-1 enzyme activity for detoxifying organophosphates and pr...
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Heart & Inflammation
|
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Moderate
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rs6511720
|
LDLR
Intron 1
|
Common regulatory variant in the LDL receptor gene affecting LDLR expression,...
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Heart & Inflammation
|
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Strong
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rs12740374
|
SORT1
1p13.3 locus
|
Regulatory variant that increases sortilin expression, lowering LDL cholester...
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Heart & Inflammation
|
|
Established
|
|
rs12785878
|
DHCR7
Near gene T>G
|
Influences vitamin D synthesis by regulating how much 7-dehydrocholesterol is...
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Nutrition & Metabolism
|
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Strong
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|
rs5128
|
APOC3
3238C>G (SstI)
|
Regulates triglyceride metabolism through effects on APOC3 expression in the ...
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Heart & Inflammation
|
|
Strong
|
|
rs58542926
|
TM6SF2
E167K
|
Lipid transport variant that impairs VLDL secretion, creating a paradoxical t...
|
Nutrition & Metabolism
|
|
Strong
|
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rs2943641
|
IRS1
Near-gene C>T
|
Regulates insulin signaling efficiency and cellular glucose uptake
|
Nutrition & Metabolism
|
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Strong
|