Tag

Cholesterol

30 genetic variants with this tag.

RSID	Gene	Description	Category
rs10455872	LPA	Intronic variant strongly associated with elevated lipoprotein(a) levels and ...	Heart & Inflammation	Cardiovascular Cholesterol Blood Thinners	Established
rs11591147	PCSK9 R46L	Loss-of-function variant that naturally lowers LDL cholesterol by 15-28% and ...	Heart & Inflammation	Cardiovascular Cholesterol Diet	Established
rs429358	APOE E4 determinant	Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high sat...	Nutrition & Metabolism	Cholesterol Cardiovascular Alzheimer's	Established
rs708272	CETP TaqIB	Influences HDL cholesterol levels and particle size through effects on choles...	Heart & Inflammation	Cardiovascular Cholesterol Longevity	Strong
rs693	APOB XbaI (C/T)	Silent variant affecting LDL particle number and lipid metabolism; A allele c...	Heart & Inflammation	Cardiovascular Cholesterol Triglycerides	Strong
rs7412	APOE E2 determinant	APOE E2 variant - generally protective for cardiovascular health	Nutrition & Metabolism	Cholesterol Cardiovascular Fat Metabolism	Established
rs662	PON1 Q192R	Affects paraoxonase-1 enzyme activity for detoxifying organophosphates and pr...	Heart & Inflammation	Cardiovascular Detoxification Cholesterol	Moderate
rs6511720	LDLR Intron 1	Common regulatory variant in the LDL receptor gene affecting LDLR expression,...	Heart & Inflammation	Cardiovascular Cholesterol Statins	Strong
rs12740374	SORT1 1p13.3 locus	Regulatory variant that increases sortilin expression, lowering LDL cholester...	Heart & Inflammation	Cholesterol Cardiovascular Lipid Metabolism	Established
rs5128	APOC3 3238C>G (SstI)	Regulates triglyceride metabolism through effects on APOC3 expression in the ...	Heart & Inflammation	Triglycerides Cardiovascular Cholesterol	Strong
rs12785878	DHCR7 Near gene T>G	Influences vitamin D synthesis by regulating how much 7-dehydrocholesterol is...	Nutrition & Metabolism	Vitamin D Bone Health Immune System	Strong
rs5882	CETP I405V	Missense variant that reduces CETP enzyme activity, raising HDL-C and enlargi...	Longevity & Aging	Longevity Aging Cholesterol	Moderate
rs1800588	LIPC -514C>T	Promoter variant that reduces hepatic lipase activity, raising HDL-C levels b...	Heart & Inflammation	Cholesterol Fat Metabolism Cardiovascular	Strong
rs1333049	CDKN2B-AS1 9p21 locus	Strongest GWAS signal for coronary artery disease; risk C allele accelerates ...	Longevity & Aging	Cardiovascular Diet Lifestyle	Established
rs4977574	CDKN2B-AS1 9p21.3	Independent 9p21.3 CAD risk signal in ANRIL; G allele elevates coronary arter...	Heart & Inflammation	Cardiovascular Atherosclerosis Diet	Established
rs58542926	TM6SF2 E167K	Lipid transport variant that impairs VLDL secretion, creating a paradoxical t...	Nutrition & Metabolism	Metabolic Cardiovascular Cholesterol	Strong
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Nutrition & Metabolism	Diabetes Insulin Cardiovascular	Strong
rs2963154	NR3C1	Intronic NR3C1 variant with TT genotype enriched in Polish centenarians; C al...	Longevity & Aging	Longevity Aging HPA Axis	Emerging
rs10515522	NR3C1	Intronic NR3C1 variant associated with longevity in Polish nonagenarians and ...	Longevity & Aging	Longevity Aging Stress Response	Emerging
rs3798220	LPA Ile4399Met (I4399M)	Missense variant in the protease-like domain of apolipoprotein(a) causing mar...	Heart & Inflammation	Cardiovascular Cholesterol Blood Thinners	Strong
rs5082	APOA2 -265T>C	Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi...	Nutrition & Metabolism	Fat Metabolism Diet Obesity	Strong
rs7566605	INSIG2	Upstream regulatory variant near INSIG2 that influences lipogenesis control a...	Nutrition & Metabolism	Obesity Fat Metabolism Diet	Moderate
rs2918418	NR3C1	Intronic NR3C1 variant with CC genotype enriched in Polish centenarians; GG g...	Longevity & Aging	Longevity Aging HPA Axis	Emerging
rs1532085	LIPC	Intronic eQTL that reduces hepatic lipase expression, raising HDL-C levels wh...	Nutrition & Metabolism	HDL Cholesterol Fat Metabolism Cholesterol	Strong
rs2642438	MTARC1 p.Ala165Thr (A165T)	Protective missense variant that reduces MTARC1 protein stability, cutting he...	Nutrition & Metabolism	Liver Health Fat Metabolism Cholesterol	Established
rs2954021	TRIB1	Near-gene variant influencing hepatic lipid metabolism; G allele raises trigl...	Nutrition & Metabolism	Triglycerides Cardiovascular Cholesterol	Established
rs7940244	NADSYN1 Near DHCR7	Intronic NADSYN1 variant in the DHCR7/NADSYN1 vitamin D locus; T allele tags ...	Nutrition & Metabolism	Vitamin D Bone Health Immune System	Strong
rs17321515	TRIB1	Near-gene variant 30–44 kb downstream of TRIB1; A allele raises triglycerides...	Nutrition & Metabolism	Triglycerides Cardiovascular Cholesterol	Strong
rs3829251	NADSYN1	Intronic NADSYN1 variant at the DHCR7/NADSYN1 vitamin D locus; A allele was t...	Nutrition & Metabolism	Vitamin D Bone Health Immune System	Strong
rs7944926	DHCR7	Near-gene intronic variant in the DHCR7/NADSYN1 locus on chromosome 11 that t...	Nutrition & Metabolism	Vitamin D Bone Health Immune System	Strong