Tag

Drug Response

20 genetic variants with this tag.

RSID	Gene	Description	Category
rs1000940	RABEP1 RABEP1 Metabolic-Immune Regulatory Variant	Intronic variant in RABEP1 associated with fasting glucose modulation under p...	Autoimmune Tolerance & T-Cell Regulation	Drug Response	Emerging
rs10305420	GLP1R Pro7Leu	GLP-1 receptor signal peptide variant that enhances semaglutide and tirzepati...	Pharmacogenomics	Drug Response	Moderate
rs11854484	SLC28A2 SLC28A2 Pro22Leu	Missense variant in the concentrative nucleoside transporter 2 (CNT2) gene th...	Vitamins & Nutrient Absorption	Drug Response	Moderate
rs1042044	GLP1R Leu260Phe	GLP-1 receptor variant in intracellular loop 2 that alters receptor surface e...	Pharmacogenomics	Drug Response	Moderate
rs1805123	KCNH2 K897T	Common KCNH2 missense variant that alters hERG potassium channel kinetics, sh...	Arrhythmia & Heart Rhythm	Drug Response	Strong
rs11206244	DIO1 C785T	Common variant in the 3' UTR of the DIO1 gene affecting thyroid hormone metab...	Hormones & Sleep	Drug Response	Strong
rs1152003	PPARG	PPARG 3'-flanking region variant — the G allele independently tags a PPARG re...	Fat Storage & Energy	Drug Response	Emerging
rs397508068	KCNQ1 Phe340del	Pathogenic in-frame 3-bp deletion in the KCNQ1 potassium channel that removes...	Arrhythmia & Heart Rhythm	Drug Response	Established
rs1800544	ADRA2A ADRA2A Promoter -1291C>G	Promoter variant that alters alpha-2A adrenergic receptor expression, affecti...	Appetite & Obesity	Drug Response	Moderate
rs17002852	CYP2D6	Synonymous CYP2D6 variant that causes allele dropout in standard CYP2D6*3 gen...	Pharmacogenomics	Drug Response	Moderate
rs1801252	ADRB1 Ser49Gly	Beta-1 adrenergic receptor variant at position 49 affecting receptor downregu...	Fitness & Body	Drug Response	Strong
rs1801253	ADRB1 Arg389Gly	Beta-1 adrenergic receptor variant where Arg389 produces higher basal activit...	Fitness & Body	Drug Response	Strong
rs396991	FCGR3A V158F	Missense variant in Fc gamma receptor IIIa (CD16a) that determines NK cell Ig...	Innate Immunity & Infection Defense	Drug Response	Strong
rs8087522	MC4R MC4R A/G (rs8087522)	Upstream regulatory variant near MC4R that may create a transcription factor ...	Appetite & Obesity	Drug Response	Emerging
rs63749869	RYR1 R4861H (Arg4861His)	RYR1 missense variant causing malignant hyperthermia susceptibility and centr...	Fitness & Body	Drug Response	Established
rs28371759	CYP3A4 *18 (L293R)	Rare missense variant causing a Leu293Arg substitution in CYP3A4, associated ...	Pharmacogenomics	Drug Response	Moderate
rs3765467	GLP1R Arg131Gln	Missense variant in the GLP-1 receptor that alters drug response to GLP-1 ago...	Pharmacogenomics	Drug Response	Moderate
rs3814637	CYP2C19	Upstream CYP2C19 variant associated with altered R-warfarin clearance and inc...	Pharmacogenomics	Drug Response	Moderate
rs58194899	EIPR1	Intronic variant in EIPR1 (endosomal trafficking protein) associated with pai...	Pharmacogenomics	Drug Response	Emerging
rs6923761	GLP1R Gly168Ser	GLP-1 receptor variant that alters response to GLP-1 agonist medications used...	Pharmacogenomics	Drug Response	Moderate