Tag

Exercise

25 genetic variants with this tag.

RSID	Gene	Description	Category
rs1042713	ADRB2 Arg16Gly	Beta-2 adrenergic receptor variant affecting receptor downregulation, exercis...	Fitness & Body	Exercise	Strong
rs113994167	ACADVL p.Val283Ala (V283A)	Most common VLCAD deficiency variant in the US, causing mild late-onset disea...	Metabolic Enzymes & Rare Disorders	Exercise	Established
rs1053049	PPARD 3'UTR variant	3'UTR variant in PPARD that acts as the third tag in the elite athlete haplot...	Fitness & Body	Exercise	Moderate
rs10852521	FTO	FTO intron 1 variant associated with BMI and body fat accumulation, with stro...	Fitness & Body	Exercise	Moderate
rs119103258	PYGM	Pathogenic missense variant in muscle glycogen phosphorylase causing post-tra...	Metabolic Enzymes & Rare Disorders	Exercise	Established
rs121907892	SLC22A12 W258X	Nonsense mutation in URAT1 that abolishes urate reabsorption in the kidney, c...	Uric Acid & Kidney Function	Exercise	Strong
rs147647315	SLC22A12 URAT1 R90H	Missense variant in URAT1 reducing urate reabsorption in the kidney, causing ...	Uric Acid & Kidney Function	Exercise	Strong
rs2911463	PIEZO1	Intronic variant in PIEZO1, the endothelial mechanosensory ion channel that s...	Arrhythmia & Heart Rhythm	Exercise	Strong
rs17219084	FTO	FTO intron variant in the extended obesity-associated region, with explorator...	Fitness & Body	Exercise	Emerging
rs17602729	AMPD1 C34T (Q12X)	Enzyme critical for energy production during high-intensity exercise; deficie...	Fitness & Body	Exercise	Strong
rs201065226	CPT2 p.Arg124Ter (R124X)	Rare stop-gain variant in CPT2 abolishing carnitine palmitoyltransferase II, ...	Metabolic Enzymes & Rare Disorders	Exercise	Strong
rs1800764	ACE Promoter T>C	Upstream promoter-region ACE variant on a separate LD block from the I/D poly...	Fitness & Body	Exercise	Moderate
rs17036314	PPARG	Intronic PPARG variant — carriers of the C allele have elevated fasting gluco...	Fat Storage & Energy	Exercise	Moderate
rs1801253	ADRB1 Arg389Gly	Beta-1 adrenergic receptor variant where Arg389 produces higher basal activit...	Fitness & Body	Exercise	Strong
rs267606993	PYGM PYGM Met1Val (start-loss)	Pathogenic start-codon variant in muscle glycogen phosphorylase; homozygous o...	Metabolic Enzymes & Rare Disorders	Exercise	Established
rs2016520	PPARD +294T>C	Regulatory variant that increases PPARD transcription, enhancing fat oxidatio...	Fitness & Body	Exercise	Moderate
rs2267668	PPARD Intron variant (5' region)	Intronic PPARD variant that impairs aerobic fitness gains and body compositio...	Fitness & Body	Exercise	Moderate
rs3736228	LRP5 A1330V	Wnt signaling co-receptor variant affecting bone mineral density and fracture...	Fitness & Body	Exercise	Strong
rs74315294	CPT2 p.Ser113Leu (S113L)	Missense variant in CPT2 that destabilizes the carnitine palmitoyltransferase...	Metabolic Enzymes & Rare Disorders	Exercise	Established
rs4253778	PPARA intron 7 G/C	Regulates fatty acid oxidation and muscle fiber composition, influencing endu...	Fitness & Body	Exercise	Moderate
rs6902123	PPARD	Intronic PPARD variant that independently impairs hepatic fat mobilization du...	Fitness & Body	Exercise	Moderate
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Appetite & Obesity	Exercise	Established
rs356182	SNCA	Parkinson's disease GWAS risk variant affecting alpha-synuclein expression an...	Neurology & Cognition	Exercise	Strong
rs6265	BDNF Val66Met	Key neurotrophin variant that controls activity-dependent BDNF release, affec...	Neurology & Cognition	Exercise	Strong
rs891512	NOS3	Intronic NOS3 variant that alters splicing factor binding and is associated w...	Methylation & Detox	Exercise	Moderate